The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Salicylic Acid–Independent ENHANCED DISEASE SUSCEPTIBILITY1 Signaling in Arabidopsis Immunity and Cell Death Is Regulated by the Monooxygenase FMO1 and the Nudix Hydrolase NUDT7
Open accessAbstract
Arabidopsis thaliana ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) controls defense activation and programmed cell death conditioned by intracellular Toll-related immune receptors that recognize specific pathogen effectors. EDS1 is also needed for basal resistance to invasive pathogens by restricting the progression of disease. In both responses, EDS1, assisted by its interacting partner, PHYTOALEXIN-DEFICIENT4 (PAD4), regulates accumulation of the phenolic defense molecule salicylic acid (SA) and other as yet unidentified signal intermediates. An Arabidopsis whole genome microarray experiment was designed to identify genes whose expression depends on EDS1 and PAD4, irrespective of local SA accumulation, and potential candidates of an SA-independent branch of EDS1 defense were found. We define two new immune regulators through analysis of corresponding Arabidopsis loss-of-function insertion mutants. FLAVIN-DEPENDENT MONOOXYGENASE1 (FMO1) positively regulates the EDS1 pathway, and one member (NUDT7) of a family of cytosolic Nudix hydrolases exerts negative control of EDS1 signaling. Analysis of fmo1 and nudt7 mutants alone or in combination with sid2-1, a mutation that severely depletes pathogen-induced SA production, points to SA-independent functions of FMO1 and NUDT7 in EDS1-conditioned disease resistance and cell death. We find instead that SA antagonizes initiation of cell death and stunting of growth in nudt7 mutants.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Thompson, J. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.24.4876 · Cited by 38,993
MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment
Kumar, S. (2004) · Briefings in Bioinformatics · doi:10.1093/bib/5.2.150 · Cited by 11,756
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603
Contrasting Mechanisms of Defense Against Biotrophic and Necrotrophic Pathogens
Glazebrook, J. (2005) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.43.040204.135923 · Cited by 4,367
GeneDoc : analysis and visualization of genetic variation
Nicholas, K. B., Nicholas, H. B., & Deerfield, D. W. (1997) · Medical Entomology and Zoology · Cited by 2,456
Isochorismate synthase is required to synthesize salicylic acid for plant defence
Wildermuth, M. C., Dewdney, J., Wu, G., & Ausubel, F. M. (2001) · Nature · doi:10.1038/35107108 · Cited by 2,357
Innate immunity in plants and animals: striking similarities and obvious differences
Nürnberger, T., Brunner, F., Kemmerling, B., & Piater, L. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0119.x · Cited by 1,286
Ciabarra, A., Sullivan, J., Gahn, L., Pecht, G., Heinemann, S., & Sevarino, K. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06498.1995 · Cited by 1,233
A Role for Flavin Monooxygenase-Like Enzymes in Auxin Biosynthesis
Zhao, Y., Christensen, S. K., Fankhauser, C., Cashman, J. R., Cohen, J. D., Weigel, D., & Chory, J. (2001) · Science · doi:10.1126/science.291.5502.306 · Cited by 1,225
Cited by
Salicylic acid, a multifaceted hormone to combat disease
Vlot, A. C., Dempsey, D. A., & Klessig, D. F. (2009) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.050908.135202 · Cited by 2,568
Qiu, J., Fiil, B. K., Petersen, K., Nielsen, H. B., Botanga, C. J., Thorgrimsen, S., Palma, K., Suarez‐Rodriguez, M. C., Sandbech‐Clausen, S., Lichota, J., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.147 · Cited by 503
Plant Pathogen Recognition Mediated by Promoter Activation of the Pepper Bs3 Resistance Gene
Römer, P., Hahn, S., Jordan, T., Strauß, T., Bonas, U., & Lahaye, T. (2007) · Science · doi:10.1126/science.1144958 · Cited by 458
New insights into the regulation of plant immunity by amino acid metabolic pathways
ZEIER, J. (2013) · Plant, Cell & Environment · doi:10.1111/pce.12122 · Cited by 417
Weßling, R., Epple, P., Altmann, S., He, Y., Yang, L., Henz, S. R., McDonald, N., Wiley, K., Bader, K. C., Gläßer, C., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.08.004 · Cited by 406
Metadata
- Authors
- Bartsch, M., Gobbato, E., Bednarek, P., Debey, S., Schultze, J. L., Bautor, J., & Parker, J. E.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-03-10
- Volume
- 18
- Issue
- 4
- Pages
- 1038-1051
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2118210881
- Cited by
- 502
- References
- 55
- FWCI
- 28.66
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Salicylic Acid–Independent ENHANCED DISEASE SUSCEPTIBILITY1 Signaling in Arabidopsis Immunity and Cell Death Is Regulated by the Monooxygenase FMO1 and the Nudix Hydrolase NUDT7. https://app.cochat.ai/papers/10.1105/tpc.105.039982
- The paper
- Bartsch, M., Gobbato, E., Bednarek, P., Debey, S., Schultze, J. L., Bautor, J., & Parker, J. E. (2006). Salicylic Acid–Independent ENHANCED DISEASE SUSCEPTIBILITY1 Signaling in Arabidopsis Immunity and Cell Death Is Regulated by the Monooxygenase FMO1 and the Nudix Hydrolase NUDT7. The Plant Cell. https://doi.org/10.1105/tpc.105.039982
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
