A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

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Extracellular CIRP Activates the IL-6Rα/STAT3/Cdk5 Pathway in Neurons

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Cyclin-dependent kinase 5 activator p35 over-expression and amyloid beta synergism increase apoptosis in cultured neuronal cells

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Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer’s disease

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Calpain-2/p35-p25/Cdk5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153

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Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells

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Decreased Proteasomal Function Induces Neuronal Loss and Memory Impairment

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Site-specific hyperphosphorylation of pRb in HIV-induced neurotoxicity

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PHF-like tau phosphorylation in mammalian hibernation is not associated with p25-formation

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The Cdk5/p35 Kinases Modulate Leptin-Induced STAT3 Signaling

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Correction: Cycle Checkpoint Abnormalities during Dementia: A Plausible Association with the Loss of Protection against Oxidative Stress in Alzheimer’s Disease

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Cyclin-dependent Kinase 5 and Neurodegenerative Diseases

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Antipodal Effects of p25 on Synaptic Plasticity, Learning, and Memory—Too Much of a Good Thing Is Bad

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Oncogenic parallels in Alzheimer disease

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Parameter Estimation in Computational Biology by Approximate Bayesian Computation coupled with Sensitivity AnalysisPreprint

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CDK5 Inhibits Synphilin-1 Ubiquitination and Basal Mitophagy: Implications for Parkinson’s Disease

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Alzheimer's disease: No effect of the CDK5 gene on CSF biomarkers, neuropathology or disease risk

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Expression of p25, an Aberrant Cyclin-Dependent Kinase 5 Activator, Stimulates Basal Secretion in PC12 Cells

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Navigating the kinases landscape: Impact on regulated cell death mechanisms in neurodegenerative disorders

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Taming hyper-active Cdk5: Disrupting the Cdk5–p25 axis as a therapeutic avenue for neurodegeneration and beyond

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Monoclonal antibodies and small molecules: on the cutting edge of Alzheimer’s disease therapy

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Cyclin-Dependent Kinase 5 (Cdk5): Linking Synaptic Plasticity and Neurodegeneration

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Effekte der Inhibition von ROCK und Rac1 auf Neuronen

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In vitro modelling of tau phosphorylating kinases : emphasis of Cdk5

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Cell-Penetrating Fragments of the Cdk5 Regulatory Subunit Are Protective in Models of Neurodegeneration

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Epigenetic Mechanisms Regulating Memory Formation in Health and Disease

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The Association Between Traumatic Brain Injury and Alzheimer's Disease: Mouse Models and Potential Mechanisms

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Characterisation of transgenic mouse models of Alzheimer's disease

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With Special Emphasis on Changes Occurring During Neuronal Cell Death

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SilencingofCDK5ReducesNeurofibrillaryTanglesin TransgenicAlzheimer'sMice

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El polimorfismo humano ARG72PRO de Tp53 condiciona a la susceptibilidad neuronal a B-Amiloide

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Probing the functions of microglial cyclin-dependent kinase 5 under physiological and pathological conditionsPreprint

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Assessment of Epigenetic profile in Alzheimer's disease

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CDK5

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A Retrospective Tribute to Dr. Harish Pant (1938–2023) and His Seminal Work on Cyclin Dependent Kinase 5

Hall, B., Amin, N. D., Veeranna, Hisanaga, S., & Kulkarni, A. B. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04234-5

Role and relation of cell death in Alzheimer’s disease

Hoang, D. A., Le, D. A., Do, T. M. H., & Than, V. T. (2025) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2025.06.024

The calpain-mediated proteolytic cleavage peptide P10 modulates Tau phosphorylation in Alzheimer’s disease

Chinnathambi, S., Dubey, T., & Rangappa, N. (2025) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2025.08.009

Restoration neurite growth by removing the blockage of endosome trafficking in Alzheimer-like mice

Zhao, H., Li, F., Xu, S., Du, Y., Chen, P., Wei, J., Hao, K., Liu, X., & Liu, H. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00777

G-protein coupled receptor chemokine CX3CR1 influences extracellular Tau internalization in Alzheimer’s disease

Chinnathambi, S., Rangappa, N., & Chandrashekar, M. (2025) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2025.10.023

Identification et caractérisation fonctionnelle de nouveaux sites de clivage de la protéine Tau

Derisbourg, M. J. (2015) · theses.fr (ABES) · doi:10.70675/ef5f45b0zf4e8z433fz9beaz8d2cc6de65bc

Rôle des cellules T CD4+ dans la modulation des réponses microgliales au cours de la maladie d’Alzheimer : potentialités thérapeutiques

Ahmed, D. A. (2014) · theses.fr (ABES) · doi:10.70675/9f4f1101zd66fz4e13zadffzc6a36a19d81c

Visceral adipose tissue differentially affects tau and Aβ pathology in 3xTg-AD mice

Trujillo‐Estrada, L., Bettinetti‐Luque, M., Andreo‐Lopez, J., Cunha, C. D., Morales‐Cabello, M., Campos‐Moreno, C., Sánchez‐Mejías, E., Forner, S., Martini, A. C., Sanchez-Varo, R. M., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02964-3

Targeting regulated cell death-related serine/threonine kinases to combat neurodegenerative disorders

Mansour, H. M., & El-Khatib, A. S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44173-8.00024-3

BindingDB Entry 953: 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3.

BindingDB (2006) · UC San Diego · doi:10.7270/q2br8qdd

Cyclin-Dependent Kinase 5

Ohshima, T., & Mikoshiba, K. (2009) · Springer eBooks · doi:10.1007/978-0-387-30370-3_10

Controversies over p25 in Alzheimer's disease

Nguyen, K. C., Rosales, J. L., Barboza, M., & Lee, K. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4207 · Cited by 25

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles

Tandon, A., Yu, W. H., Wang, L., Rogaeva, E. A., Sato, C., Chishti, M. A., Kawarai, T., Hasegawa, H., Chen, F., Davies, P., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01865.x · Cited by 83

Is there a role of the Cdk5-activator p25 in Alzheimer's disease?

Giese, K.-P., Ris, L., & Plattner, F. (2005) · UCL Discovery (University College London)

Cdk5, a therapeutic target for Alzheimer's disease?

Tsai, L., Lee, M.-S., & Cruz, J. C. (2003) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2003.11.019 · Cited by 122

Levels of activators of cyclin-dependent protein kinase 5 (Cdk5) p25 and p35 in Alzheimer's disease

Engmann, O., Hortobagyi, T., Thompson, A. M., & Giese, K.-P. (2010) · Research Portal (King's College London)