The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia.
Abstract
Focal cortical dysplasia (FCD) is the most common malformation of cortical development found in epilepsy surgical series. Characterised by cortical mislamination, dysplastic neurons and, in a subgroup of cases, balloon cells, FCD is potently epileptogenic. Despite decades of study, the underlying aetiology of FCD remains uncertain and research has been hampered by the lack of a good animal model in which to simulate the condition. In this article we review some of the potential molecular mechanisms that might underpin human FCD. In particular we examine the potential role of cyclin-dependent kinase 5 and its principal activator p35 in FCD and estimate the contribution that deregulation of cyclin-dependent kinase 5 might make to the pathogenesis of this condition.
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Both GSK-3β and CDK5 play a role in neuronal excitability through involvement in GABAergic and glutamatergic neurotransmission.
“Both GSK-3β and CDK5 play a role in neuronal excitability through involvement in GABAergic and glutamatergic neurotransmission, and inhibiting their activity can affect network activity through various mechanisms (Sen et al., 2008; Jaworski, 2020; Toral-Rios et al., 2020; Banerjee et al., 2021).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Sen et al., 2008
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- Authors
- Sen, A., Thom, M., Nikolić, M., & Sisodiya, S. M.
- Affiliations
- University College London (GB)
- UCL Queen Square Institute of Neurology (GB)
- Imperial College London (GB)
- Venue
- Developmental Neuroscience
- Publisher
- S. Karger AG
- Published
- 2007-12-13
- Volume
- 30
- Issue
- 1-3
- Pages
- 96-104
- ISSN
- 0378-5866 (ISSN-L)
- 1421-9859
- OpenAlex
- W1991714817
- Cited by
- 10
- References
- 53
- Citations by year
- 2022: 2 · 2021: 1 · 2020: 1 · 2018: 2
- FWCI
- 0.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- University College London
- Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- focal cortical dysplasia, cyclin-dependent kinase 5, p35, malformations of cortical development, epilepsy, balloon cells, epileptogenesis, pathogenesis, animal models
- MeSH terms
- Cell Movement, Cerebral Cortex, Enzyme Activation, Epilepsy, Humans, Signal Transduction, Gene Expression Regulation, Developmental, Cell Cycle Proteins, Adaptor Proteins, Signal Transducing, Cyclin-Dependent Kinase 5, Malformations of Cortical Development
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