The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
T‐0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor‐deficient mice
Abstract
Liver X receptors (LXRα and LXRβ) are nuclear receptors, which are important regulators of cholesterol and lipid metabolism. LXRs control genes involved in cholesterol efflux in macrophages, bile acid synthesis in liver and intestinal cholesterol absorption. LXRs also regulate genes participating in lipogenesis. To determine whether the activation of LXR promotes or inhibits development of atherosclerosis, T‐0901317, a synthetic LXR ligand, was administered to low density lipoprotein receptor (LDLR)−/− mice. T‐0901317 significantly reduced the atherosclerotic lesions in LDLR−/− mice without affecting plasma total cholesterol levels. This anti‐atherogenic effect correlated with the plasma concentration of T‐0901317, but not with high density lipoprotein cholesterol, which was increased by T‐0901317. In addition, we observed that T‐0901317 increased expression of ATP binding cassette A1 in the lesions in LDLR−/− mice as well as in mouse peritoneal macrophages. T‐0901317 also significantly induced cholesterol efflux activity in peritoneal macrophages. These results suggest that LXR ligands may be useful therapeutic agents for the treatment of atherosclerosis.
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Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
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Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers
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A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
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Cited by
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
Calkin, A. C., & Tontonoz, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3312 · Cited by 779
Molecular regulation of HDL metabolism and function: implications for novel therapies
Rader, D. J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci30163 · Cited by 599
Liver X receptors in lipid metabolism: opportunities for drug discovery
Hong, C., & Tontonoz, P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4280 · Cited by 587
Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics
Huang, P., Chandra, V., & Rastinejad, F. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135917 · Cited by 533
Mouse Models for Atherosclerosis and Pharmaceutical Modifiers
Zadelaar, S., Kleemann, R., Verschuren, L., de Vries-Van der Weij, J., van der Hoorn, J., Princen, H. M., & Kooistra, T. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.142570 · Cited by 527
Metadata
- Authors
- Terasaka, N., Hiroshima, A., Koieyama, T., Ubukata, N., Morikawa, Y., Nakai, D., & Inaba, T.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2002-10-22
- Volume
- 536
- Issue
- 1-3
- Pages
- 6-11
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2026587556
- Cited by
- 326
- References
- 26
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Terasaka, N., Hiroshima, A., Koieyama, T., Ubukata, N., Morikawa, Y., Nakai, D., & Inaba, T. (2003). T‐0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor‐deficient mice. FEBS Letters. https://doi.org/10.1016/s0014-5793(02)03578-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
