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Cited by 1,591

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

An oxysterol signalling pathway mediated by the nuclear receptor LXRα

Janowski, Bethany A., Willy, Patricia J., Devi, Thota Rama, Falck, J. R., Mangelsdorf, David J.·1996·Nature
DOI 10.1038/383728a0
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Abstract

Cholesterol and its oxysterol congeners are important constituents of cell membranes and function as intermediates in several crucial biosynthetic pathways. These compounds autoregulate their metabolic fate by end-product repression and activation of downstream catabolism. Although end-product repression by oxysterols is relatively well understood, the mechanism by which these compounds act as positive transcription signalling molecules is unknown. Here we identify a specific group of endogenous oxysterols that activate transcription through the nuclear receptor LXR alpha. Transactivation of LXR alpha by oxysterols occurs at concentrations at which these compounds exist in vivo. The most potent activators also serve as intermediary substrates in the rate-limiting steps of three important metabolic pathways: steroid hormone biosynthesis, bile acid synthesis, and conversion of lanosterol to cholesterol. Our results demonstrate the existence of a nuclear receptor signalling pathway for oxysterols and suggest that LXR alpha may be important as a sensor of cholesterol metabolites.

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Crossref · 10.1038/383728a0

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3 of 3 references verified0 citation errors · 0 not checkable

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Citations

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Metadata

Authors
Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., & Mangelsdorf, D. J.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1996-10
Volume
383
Issue
6602
Pages
728-731
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/383728a0
Cited by
1,591
References
3
Language
en
Licence
www.springer.com/tdm (tdm)

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