Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme
Abstract
ACE 2, a novel homologue of angiotensin converting enzyme, has recently been identified. This study used QRT‐PCR to quantitatively map the transcriptional expression profile of ACE 2 (and the two isoforms of ACE) in 72 human tissues. While confirming that ACE 2 expression is high in renal and cardiovascular tissues, the novel observation has been made that ACE 2 shows comparably high levels of expression in the gastrointestinal system, in particular in ileum, duodenum, jejunum, caecum and colon. Therefore, in probing the functional significance of this novel peptidase, some consideration should be given to a role in gastrointestinal physiology and pathophysiology.
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Bulk data on ACE2 distribution cannot indicate cell type-specific expression.
“Previous studies have investigated the ACE2 mRNA and protein expression in various tissues by bulk samples17,18, however, the distribution of ACE2 through bulk data could not indicate the cell type-specific expression of ACE2.”
From High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa (2020) · cites this paper as [17]
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- Authors
- Harmer, D., Gilbert, M., Borman, R., & Clark, K. L.
- Corresponding author
- Harmer, Dan
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2002-11-07
- Volume
- 532
- Issue
- 1-2
- Pages
- 107-110
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1974901207
- Cited by
- 852
- References
- 12
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 33 · 2023: 56 · 2022: 80 · 2021: 187 · 2020: 277 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 9 · 2014: 9 · 2013: 8 · 2012: 9
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Oncology › Peptidase Inhibition and Analysis
- Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Keywords
- ACE2, angiotensin-converting enzyme, mRNA expression profiling, human tissue, gastrointestinal tract, ileum, duodenum, jejunum, cecum, colon, kidney tissue, cardiovascular tissue, digestive physiology
- MeSH terms
- Angiotensin-Converting Enzyme 2, Carboxypeptidases, Digestive System, Humans, Peptidyl-Dipeptidase A, RNA, Messenger, Tissue Distribution, Transcription, Genetic, Protein Isoforms, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling
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