Cited by 852Renin-Angiotensin System StudiesPeptidase Inhibition and AnalysisCoagulation, Bradykinin, Polyphosphates, and Angioedema

Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme

Harmer, Dan, Gilbert, Maureen, Borman, Richard, Clark, Kenneth L·2002·FEBS Letters

Abstract

ACE 2, a novel homologue of angiotensin converting enzyme, has recently been identified. This study used QRT‐PCR to quantitatively map the transcriptional expression profile of ACE 2 (and the two isoforms of ACE) in 72 human tissues. While confirming that ACE 2 expression is high in renal and cardiovascular tissues, the novel observation has been made that ACE 2 shows comparably high levels of expression in the gastrointestinal system, in particular in ileum, duodenum, jejunum, caecum and colon. Therefore, in probing the functional significance of this novel peptidase, some consideration should be given to a role in gastrointestinal physiology and pathophysiology.

Integrity signals

Registry

Crossref · 10.1016/s0014-5793(02)03640-2

Cites

12 of 12 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Bulk data on ACE2 distribution cannot indicate cell type-specific expression.

    “Previous studies have investigated the ACE2 mRNA and protein expression in various tissues by bulk samples17,18, however, the distribution of ACE2 through bulk data could not indicate the cell type-specific expression of ACE2.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Harmer, D., Gilbert, M., Borman, R., & Clark, K. L.
Corresponding author
Harmer, Dan
Venue
FEBS Letters
Publisher
Wiley
Published
2002-11-07
Volume
532
Issue
1-2
Pages
107-110
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W1974901207
Cited by
852
References
12
Citations by year
2026: 12 · 2025: 12 · 2024: 33 · 2023: 56 · 2022: 80 · 2021: 187 · 2020: 277 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 9 · 2014: 9 · 2013: 8 · 2012: 9
FWCI
11.57
Type
journal article
Language
en
Open access
closed
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Oncology › Peptidase Inhibition and Analysis
  • Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
Keywords
ACE2, angiotensin-converting enzyme, mRNA expression profiling, human tissue, gastrointestinal tract, ileum, duodenum, jejunum, cecum, colon, kidney tissue, cardiovascular tissue, digestive physiology
MeSH terms
Angiotensin-Converting Enzyme 2, Carboxypeptidases, Digestive System, Humans, Peptidyl-Dipeptidase A, RNA, Messenger, Tissue Distribution, Transcription, Genetic, Protein Isoforms, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review