The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23
Abstract
The orphan receptor ChemR23 is a G‐protein coupled receptor (GPCR) with homology to neuropeptide and chemoattractant receptors. Tazarotene, a synthetic retinoid activating retinoic acid receptor (RAR), up‐regulates tazarotene‐induced gene‐2 (TIG2). The function and molecular target of this protein are now described. By means of reverse pharmacology screening using a peptide library generated from human hemofiltrate, we have isolated and identified TIG2 as the natural ligand of ChemR23 and report the specific molecular form of the bioactive, circulating TIG2, representing the amino‐acid residues 21 to 154 of the 163 amino acid‐containing prepropeptide. Based on the expression pattern of ChemR23 and TIG2, the physiological role in bone development, immune and inflammatory responses and the maintenance of skin is now being investigated.
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Wittamer, V., Franssen, J.-D., Vulcano, M., Mirjolet, J.-F., Le Poul, E., Migeotte, I., Brézillon, S., Tyldesley, R., Blanpain, C., Detheux, M., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030382 · Cited by 888
Cited by
Connor, K. M., SanGiovanni, J. P., Lofqvist, C., Aderman, C. M., Chen, J., Higuchi, A., Hong, S., Pravda, E. A., Majchrzak, S., Carper, D., et al. (2007) · Nature Medicine · doi:10.1038/nm1591 · Cited by 688
The genetic design of signaling cascades to record receptor activation
Barnea, G., Strapps, W., Herrada, G., Berman, Y., Ong, J., Kloss, B., Axel, R., & Lee, K. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710487105 · Cited by 678
Synthetic chemerin-derived peptides suppress inflammation through ChemR23
Cash, J. L., Hart, R., Russ, A., Dixon, J. P. C., Colledge, W. H., Doran, J., Hendrick, A. G., Carlton, M. B. L., & Greaves, D. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071601 · Cited by 372
Kaur, J., Adya, R., Tan, B. K., Chen, J., & Randeva, H. S. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.150 · Cited by 349
Recinella, L., Orlando, G., Ferrante, C., Chiavaroli, A., Brunetti, L., & Leone, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.578966 · Cited by 261
Metadata
- Authors
- Meder, W., Wendland, M., Busmann, A., Kutzleb, C., Spodsberg, N., John, H., Richter, R., Schleuder, D., Meyer, M., & Forssmann, W. G.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2003-11-19
- Volume
- 555
- Issue
- 3
- Pages
- 495-499
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1982368439
- Cited by
- 205
- References
- 1
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Meder, W., Wendland, M., Busmann, A., Kutzleb, C., Spodsberg, N., John, H., Richter, R., Schleuder, D., Meyer, M., & Forssmann, W. G. (2003). Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23. FEBS Letters. https://doi.org/10.1016/s0014-5793(03)01312-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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