Adipokines: New potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases
Open accessAbstract
Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic and complex endocrine organ, which produces and secretes several adipokines, including hormones, cytokines, extracellular matrix (ECM) proteins, and growth and vasoactive factors. A wide body of evidence showed that adipokines play a critical role in various biological and physiological functions, among which feeding modulation, inflammatory and immune function, glucose and lipid metabolism, and blood pressure control. The aim of this review is to summarize the effects of several adipokines, including leptin, diponectin, resistin, chemerin, lipocalin-2 (LCN2), vaspin, omentin, follistatin-like 1 (FSTL1), secreted protein acidic and rich in cysteine (SPARC), secreted frizzled-related protein 5 (SFRP5), C1q/TNF-related proteins (CTRPs), family with sequence similarity to 19 member A5 (FAM19A5), wingless-type inducible signaling pathway protein-1 (WISP1), progranulin (PGRN), nesfatin-1 (nesfatin), visfatin/PBEF/NAMPT, apelin, retinol binding protein 4 (RPB4), and plasminogen activator inhibitor-1 (PAI-1) in the regulation of insulin resistance and vascular function, as well as many aspects of inflammation and immunity and their potential role in managing obesity-associated diseases, including metabolic, osteoarticular, and cardiovascular diseases.
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LCN2 receptors megalin/GP330 and SLC22A17 or 24p3R are involved in regulating inflammation and transport of fatty acids and iron.
“Its receptors, the megalin/glycoprotein GP330 and SLC22A17 or 24p3R, the solute carrier family 22 members 17 binding mouse LCN2, are involved in regulating inflammation and the transport of fatty acids and iron [23].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [23]
SPARC/BM40/osteonectin modulates expression of pro-inflammatory cytokines involved in insulin resistance and adipogenesis.
“The secreted acidic protein rich in cysteine (SPARC), known as BM40 or osteonectin, modulates the expression of pro-inflammatory cytokines involved in insulin resistance and adipogenesis [23].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [23]
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Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions
de Oliveira dos Santos, A. R., de Oliveira Zanuso, B., Miola, V. F. B., Barbalho, S. M., Santos Bueno, P. C., Flato, U. A. P., Detregiachi, C. R. P., Buchaim, D. V., Buchaim, R. L., Tofano, R. J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052639 · Cited by 189 · see citing works
Zhao, F., He, Y., Zhao, Z., He, J., Huang, H., Ai, K., Liu, L., & Cai, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1272133 · Cited by 42 · see citing works
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Baumgartner, M., Lischka, J., Schanzer, A., de Gier, C., Walleczek, N.-K., Greber-Platzer, S., & Zeyda, M. (2022) · Nutrients · doi:10.3390/nu14102133 · Cited by 9 · see citing works
- Authors
- Recinella, L., Orlando, G., Ferrante, C., Chiavaroli, A., Brunetti, L., & Leone, S.
- Affiliations
- University of Chieti-Pescara (IT)
- Corresponding author
- Brunetti, Luigi
- ORCID
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2020-10-30
- Volume
- 11
- Pages
- 578966-578966
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC7662468
- OpenAlex
- W3097383352
- Cited by
- 261
- References
- 527
- Citations by year
- 2026: 25 · 2025: 52 · 2024: 56 · 2023: 56 · 2022: 47 · 2021: 25
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipokines, adipose tissue endocrine function, obesity, insulin resistance, vascular function, inflammation, immune function, leptin, adiponectin, resistin, chemerin, neutrophil gelatinase-associated lipocalin, vaspin, omentin, FSTL1, SPARC, SFRP5, CTRP, WISP1, progranulin, nesfatin-1, visfatin, apelin, retinol-binding protein 4, plasminogen activator inhibitor-1, metabolic disorders, rheumatic diseases, cardiovascular disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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