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Primary structure of a putative serine protease specific for IGF‐binding proteins
Abstract
From a subtracted cDNA library we have isolated a cDNA clone coding for a novel transformation‐sensitive protein which is expressed by human fibroblasts, but not by their matched SV40 transformed counterparts. This protein has a molecular mass of 51 kDa and is highly related to the HtrA family of serine proteases from bacteria. At the N‐terminal end, it contains an IGF‐binding domain which may modulate the activity of the associated serine protease. Our data are consistent with the assumption that the novel protein represents one of the proteases that regulate the availability of IGFs by cleaving IGF‐binding proteins.
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Cited by
HtrA1 serine protease inhibits signaling mediated by Tgfβ family proteins
Oka, C., Tsujimoto, R., Kajikawa, M., Koshiba-Takeuchi, K., Ina, J., Yano, M., Tsuchiya, A., Ueta, Y., Soma, A., Kanda, H., et al. (2004) · Development · doi:10.1242/dev.00999 · Cited by 334
Hoy, B., Löwer, M., Weydig, C., Carra, G., Tegtmeyer, N., Geppert, T., Schröder, P., Sewald, N., Backert, S., Schneider, G., et al. (2010) · The EMBO Reports · doi:10.1038/embor.2010.114 · Cited by 295
Demoor, M., Ollitrault, D., Gomez-Leduc, T., Bouyoucef, M., Hervieu, M., Fabre, H., Lafont, J., Denoix, J.-M., Audigié, F., Mallein-Gerin, F., et al. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.02.030 · Cited by 296
Implications of the serine protease HtrA1 in amyloid precursor protein processing
Grau, S., Baldi, A., Bussani, R., Tian, X., Stefanescu, R., Przybylski, M., Richards, P., Jones, S. A., Shridhar, V., Clausen, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501823102 · Cited by 215
Metadata
- Authors
- Zumbrunn, J., & Trueb, B.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-12-02
- Volume
- 398
- Issue
- 2-3
- Pages
- 187-192
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2007608938
- Cited by
- 212
- References
- 0
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zumbrunn, J., & Trueb, B. (1996). Primary structure of a putative serine protease specific for IGF‐binding proteins. FEBS Letters. https://doi.org/10.1016/s0014-5793(96)01229-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
