Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E‐cadherin to disrupt intercellular adhesion

Basic local alignment search tool

Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669 · see citing works

Helicobacter pylori and gastrointestinal tract adenocarcinomas

Peek, R. M., & Blaser, M. J. (2002) · Nature reviews. Cancer · doi:10.1038/nrc703 · Cited by 1,807 · see citing works

Disruption of the Epithelial Apical-Junctional Complex by Helicobacter pylori CagA

Amieva, M. R., Vogelmann, R., Covacci, A., Tompkins, L. S., Nelson, W. J., & Falkow, S. (2003) · Science · doi:10.1126/science.1081919 · Cited by 739 · see citing works

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1

Noë, V., Fingleton, B., Jacobs, K., Crawford, H. C., Vermeulen, S. J. T., Steelant, W. F. A., Bruyneel, E. A., Matrisian, L. M., & Mareel, M. M. K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.1.111 · Cited by 697 · see citing works

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation

Maretzky, T., Reiß, K., Ludwig, A., Buchholz, J., Scholz, F., Proksch, E., Strooper, B. D., Hartmann, D., & Säftig, P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500918102 · Cited by 663 · see citing works

Helicobacter pylori VacA, a paradigm for toxin multifunctionality

Cover, T. L., & Blanke, S. R. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1095 · Cited by 569 · see citing works

Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells

Murata-Kamiya, N., Kurashima, Y., Teishikata, Y., Yamahashi, Y., Saito, Y., Higashi, H., Aburatani, H., Akiyama, T., Peek, R. M., Azuma, T., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210251 · Cited by 468 · see citing works

Structural basis for the regulated protease and chaperone function of DegP

Krojer, T. J., Sawa-Makarska, J. Z., Schäfer, E., Saibil, H. R., Ehrmann, M., & Clausen, T. (2008) · Nature · doi:10.1038/nature07004 · Cited by 368 · see citing works

Global Transposon Mutagenesis and Essential Gene Analysis of Helicobacter pylori

Salama, N. R., Shepherd, B., & Falkow, S. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.23.7926-7935.2004 · Cited by 309 · see citing works

The Role of Human HtrA1 in Arthritic Disease

Grau, S., Richards, P. J., Kerr, B. C., Hughes, C., Caterson, B., Williams, A. S., JUNKER, U., Jones, S. A., Clausen, T., & Ehrmann, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500361200 · Cited by 290 · see citing works

Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin.

Papini, E., Satin, B., Norais, N., de Bernard, M., Telford, J. L., Rappuoli, R., & Montecucco, C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2764 · Cited by 248 · see citing works

Intracellular, Intercellular, and Stromal Invasion of Gastric Mucosa, Preneoplastic Lesions, and Cancer by Helicobacter pylori

Necchi, V., Candusso, M. E., Tava, F., Luinetti, O., Ventura, U., Fiocca, R., Ricci, V., & Solcia, E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.049 · Cited by 243 · see citing works

Primary structure of a putative serine protease specific for IGF‐binding proteins

Zumbrunn, J., & Trüeb, B. (1996) · FEBS Letters · doi:10.1016/s0014-5793(96)01229-x · Cited by 212 · see citing works

Helicobacter pylori Dysregulation of Gastric Epithelial Tight Junctions by Urease-Mediated Myosin II Activation

Wroblewski, L. E., Shen, L., Ogden, S., Romero–Gallo, J., Lapierre, L. A., Israel, D. A., Turner, J. R., & Peek, R. M. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.10.011 · Cited by 193 · see citing works

Proteases in bacterial pathogenesis

Ingmer, H., & Brøndsted, L. (2009) · Research in Microbiology · doi:10.1016/j.resmic.2009.08.017 · Cited by 172 · see citing works

Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins

Jiang, J., Zhang, X., Chen, Y., Wu, Y., Zhou, Z. H., Chang, Z., & Sui, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805464105 · Cited by 160 · see citing works

E-cadherin in gastric cancer

Chan, A. O. O. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i2.199 · Cited by 118 · see citing works

Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori

Weßler, S., & Backert, S. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2008.05.005 · Cited by 113 · see citing works

Prediction of Extracellular Proteases of the Human Pathogen Helicobacter pylori Reveals Proteolytic Activity of the Hp1018/19 Protein HtrA

Löwer, M., Weydig, C., Metzler, D., Reuter, A., Starzinski‐Powitz, A., Weßler, S., & Schneider, G. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003510 · Cited by 84 · see citing works

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli

Meltzer, M., Hasenbein, S., Mamant, N., Merdanovic, M., Poepsel, S., Hauske, P., Kaiser, M., Huber, R., Krojer, T. J., Clausen, T., et al. (2009) · Research in Microbiology · doi:10.1016/j.resmic.2009.07.012 · Cited by 77 · see citing works

p120 and Kaiso RegulateHelicobacter pylori-induced Expression of Matrix Metalloproteinase-7

Ogden, S. R., Wroblewski, L. E., Weydig, C., Romero–Gallo, J., O’Brien, D., Israel, D. A., Krishna, U. S., Fingleton, B., Reynolds, A. B., Weßler, S., et al. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-03-0283 · Cited by 72 · see citing works

CagA-independent disruption of adherence junction complexes involves E-cadherin shedding and implies multiple steps in Helicobacter pylori pathogenicity

Weydig, C., Starzinski‐Powitz, A., Carra, G., Löwer, J., & Weßler, S. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.07.015 · Cited by 69 · see citing works

Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection

Schirrmeister, W., Gnad, T., Wex, T., Higashiyama, S., Wolke, C., Naumann, M., & Lendeckel, U. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.07.029 · Cited by 59 · see citing works

Pathobiology of Helicobacter pylori–Induced Gastric Cancer

Amieva, M. R., & Peek, R. M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.09.004 · Cited by 907 · see citing works

HTRA proteases: regulated proteolysis in protein quality control

Clausen, T., Kaiser, M., Huber, R., & Ehrmann, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3065 · Cited by 479 · see citing works

Helicobacter pylori Virulence Factors—Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment

Baj, J., Forma, A., Sitarz, M., Portincasa, P., Garruti, G., Krasowska, D., & Maciejewski, R. (2020) · Cells · doi:10.3390/cells10010027 · Cited by 389 · see citing works

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

Ansari, S., & Yamaoka, Y. (2019) · Toxins · doi:10.3390/toxins11110677 · Cited by 295 · see citing works

Role of the cag ‐pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis

Tegtmeyer, N., Weßler, S., & Backert, S. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08035.x · Cited by 250 · see citing works

Helicobacter pylori: an up-to-date overview on the virulence and pathogenesis mechanisms

Sharndama, H. C., & Mba, I. E. (2022) · Brazilian Journal of Microbiology · doi:10.1007/s42770-021-00675-0 · Cited by 266 · see citing works

Epithelial E- and P-cadherins: Role and clinical significance in cancer

Paredes, J., Figueiredo, J., Albergaria, A., Oliveira, P., Carvalho, J., Ribeiro, A. S., Caldeira, J., Costa, Â. M., Simões‐Correia, J., Oliveira, M. J., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.05.002 · Cited by 230 · see citing works

The impacts of H. pylori virulence factors on the development of gastroduodenal diseases

Chang, W.-L., Yeh, Y.-C., & Sheu, B. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0466-9 · Cited by 221 · see citing works

Proteases and protease inhibitors in infectious diseases

Agbowuro, A. A., Huston, W. M., Gamble, A. B., & Tyndall, J. D. A. (2017) · Medicinal Research Reviews · doi:10.1002/med.21475 · Cited by 188 · see citing works

The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis

Posselt, G., Backert, S., & Weßler, S. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-77 · Cited by 179 · see citing works

Protein Quality Control in the Bacterial Periplasm

Merdanovic, M., Clausen, T., Kaiser, M., Huber, R., & Ehrmann, M. (2010) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102925 · Cited by 182 · see citing works

Linkages between oral commensal bacteria and atherosclerotic plaques in coronary artery disease patients

Chhibber‐Goel, J., Singhal, V., Bhowmik, D., Vivek, R., Parakh, N., Bhargava, B., & Sharma, A. (2016) · npj Biofilms and Microbiomes · doi:10.1038/s41522-016-0009-7 · Cited by 179 · see citing works

Effect ofHelicobacter pylorion gastric epithelial cells

Alzahrani, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i36.12767 · Cited by 175 · see citing works

Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori

Backert, S., Clyne, M., & Tegtmeyer, N. (2011) · Cell Communication and Signaling · doi:10.1186/1478-811x-9-28 · Cited by 174 · see citing works

Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin

Hoy, B., Geppert, T., Boehm, M., Reisen, F., Plattner, P., Gadermaier, G., Sewald, N., Ferreira, F., Briza, P., Schneider, G., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.c111.333419 · Cited by 171 · see citing works

Proteomic analysis of Vibrio cholerae outer membrane vesicles

Altındiş, E., Fu, Y., & Mekalanos, J. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403683111 · Cited by 170 · see citing works

Bacterial Proteases and Virulence

Frees, D., Brøndsted, L., & Ingmer, H. (2013) · Subcellular Biochemistry · doi:10.1007/978-94-007-5940-4_7 · Cited by 159 · see citing works

Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery

Tegtmeyer, N., Wessler, S., Necchi, V., Rohde, M., Harrer, A., Rau, T. T., Asche, C. I., Boehm, M., Loessner, H., Figueiredo, C., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.09.005 · Cited by 156 · see citing works

Campylobacter jejuni outer membrane vesicle-associated proteolytic activity promotes bacterial invasion by mediating cleavage of intestinal epithelial cell E-cadherin and occludin

Elmi, A., Nasher, F., Jagatia, H., Gundogdu, O., Bajaj‐Elliott, M., Wren, B. W., & Dorrell, N. (2015) · Cellular Microbiology · doi:10.1111/cmi.12534 · Cited by 146 · see citing works

Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin

Boehm, M., Hoy, B., Rohde, M., Tegtmeyer, N., Bæk, K. T., Oyarzábal, O. A., Brøndsted, L., Weßler, S., & Backert, S. (2012) · Gut Pathogens · doi:10.1186/1757-4749-4-3 · Cited by 142 · see citing works

Bacterial Moonlighting Proteins and Bacterial Virulence

Henderson, B. E., & Martin, A. C. R. (2011) · Current topics in microbiology and immunology · doi:10.1007/82_2011_188 · Cited by 138 · see citing works

Extracellular HtrA serine proteases: An emerging new strategy in bacterial pathogenesis

Backert, S., Bernegger, S., Skórko‐Glonek, J., & Weßler, S. (2018) · Cellular Microbiology · doi:10.1111/cmi.12845 · Cited by 133 · see citing works

Beyond a tumor suppressor: Soluble E ‐cadherin promotes the progression of cancer

Hu, Q., Kuang, J., Yang, Q., Bian, X., & Yu, S. (2015) · International Journal of Cancer · doi:10.1002/ijc.29982 · Cited by 131 · see citing works

Bacterial outer membrane vesicles in disease and preventive medicine

Ünal, C., Schaar, V., & Riesbeck, K. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0231-y · Cited by 130 · see citing works

Helicobacter pylori in Gastric Carcinogenesis

Wroblewski, L. E., & Peek, R. M. (2013) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2013.01.006 · Cited by 126 · see citing works

Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response

Hansen, G., & Hilgenfeld, R. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1076-4 · Cited by 123 · see citing works

Bacterial proteases in IBD and IBS

Steck, N., Mueller, K., Schemann, M., & Haller, D. (2011) · Gut · doi:10.1136/gutjnl-2011-300775 · Cited by 119 · see citing works

Impact of enteric bacterial infections at and beyond the epithelial barrier

Rogers, A. P., Mileto, S. J., & Lyras, D. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00794-x · Cited by 128 · see citing works

Interaction with the host: the role of fibronectin and extracellular matrix proteins in the adhesion of Gram-negative bacteria

Vaca, D. J., Thibau, A., Schütz, M. S., Kraiczy, P., Happonen, L., Malmström, J. A., & Kempf, V. A. J. (2019) · Medical Microbiology and Immunology · doi:10.1007/s00430-019-00644-3 · Cited by 117 · see citing works

Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy

Al-Rabadi, L. F., Caza, T. N., Avillach, C., Rodan, A. R., Andeen, N. K., Hayashi, N., Williams, B. L., Revelo, M. P., Clayton, F., Abraham, J., et al. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020101395 · Cited by 115 · see citing works

Transmigration route of Campylobacter jejuni across polarized intestinal epithelial cells: paracellular, transcellular or both?

Backert, S., Boehm, M., Weßler, S., & Tegtmeyer, N. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-72 · Cited by 115 · see citing works

An Introduction to Bacterial Biofilms and Their Proteases, and Their Roles in Host Infection and Immune Evasion

Ramírez-Larrota, J. S., & Eckhard, U. (2022) · Biomolecules · doi:10.3390/biom12020306 · Cited by 108 · see citing works

Probiotic Escherichia coli inhibits biofilm formation of pathogenic E. coli via extracellular activity of DegP

Fang, K., Jin, X., & Hong, S. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-23180-1 · Cited by 106 · see citing works

Bacterial proteolytic complexes as therapeutic targets

Raju, R. M., Goldberg, A. L., & Rubin, E. J. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3846 · Cited by 105 · see citing works

Comparative Whole Genome Sequence Analysis of the Carcinogenic Bacterial Model Pathogen Helicobacter felis

Arnold, I. C., Zigova, Z., Holden, M. T. G., Lawley, T. D., Rad, R., Dougan, G., Falkow, S., Bentley, S. D., & Mueller, A. (2011) · Genome Biology and Evolution · doi:10.1093/gbe/evr022 · Cited by 94 · see citing works

Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ 5 -integrin–integrin linked kinase signalling complex

Wiedemann, T., Hofbaur, S., Tegtmeyer, N., Huber, S., Sewald, N., Weßler, S., Backert, S., & Rieder, G. (2012) · Gut · doi:10.1136/gutjnl-2011-300525 · Cited by 102 · see citing works

Type IV Secretion and Signal Transduction of Helicobacter pylori CagA through Interactions with Host Cell Receptors

Backert, S., & Tegtmeyer, N. (2017) · Toxins · doi:10.3390/toxins9040115 · Cited by 95 · see citing works

The emerging roles of bacterial proteases in intestinal diseases

Caminero, A., Guzman, M., Libertucci, J., & Lomax, A. E. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2181922 · Cited by 92 · see citing works

The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice

Heimesaat, M. M., Alutis, M. E., Grundmann, U., Fischer, A., Tegtmeyer, N., Böhm, M., Kühl, A. A., Göbel, U. B., Backert, S., & Bereswill, S. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00077 · Cited by 92 · see citing works

Diffuse Gastric Cancer: A Summary of Analogous Contributing Factors for Its Molecular Pathogenicity

Ansari, S., Gantuya, B., Tuan, V. P., & Yamaoka, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082424 · Cited by 90 · see citing works

A single-nucleotide polymorphism in Helicobacter pylori promotes gastric cancer development

Sharafutdinov, I., Tegtmeyer, N., Linz, B., Rohde, M., Vieth, M. W., Tay, C. Y., Lamichhane, B., Tuan, V. P., Fauzia, K. A., Sticht, H., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.06.016 · Cited by 94 · see citing works

E‐cadherin dysfunction in gastric cancer ‐ Cellular consequences, clinical applications and open questions

Carneiro, P., Fernandes, M. S., Figueiredo, J., Caldeira, J., Carvalho, J., Pinheiro, H. C., Leite, M., Melo, S., Oliveira, P., Simões‐Correia, J., et al. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.07.045 · Cited by 89 · see citing works

Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA

Schmidt, T. P., Perna, A. M., Fugmann, T., Böhm, M., Hiss, J. A., Haller, S., Goetz, C., Tegtmeyer, N., Hoy, B., Rau, T. T., et al. (2016) · Scientific Reports · doi:10.1038/srep23264 · Cited by 89 · see citing works

Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine

Stein, M., Ruggiero, P., Rappuoli, R., & Bagnoli, F. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00328 · Cited by 88 · see citing works

Rational design of allosteric modulators: Challenges and successes

Chatzigoulas, A., & Cournia, Z. (2021) · Wiley Interdisciplinary Reviews Computational Molecular Science · doi:10.1002/wcms.1529 · Cited by 87 · see citing works

The HtrA Protease from Streptococcus pneumoniae Digests Both Denatured Proteins and the Competence-stimulating Peptide

Cassone, M., Gagne, A. L., Spruce, L. A., Seeholzer, S. H., & Sebert, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.391482 · Cited by 86 · see citing works

Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells

Pachathundikandi, S. K., Tegtmeyer, N., & Backert, S. (2013) · Gut Microbes · doi:10.4161/gmic.27001 · Cited by 83 · see citing works

Analysis of Surface-Exposed Outer Membrane Proteins in Helicobacter pylori

Voss, B. J., Gaddy, J. A., McDonald, W. H., & Cover, T. L. (2014) · Journal of Bacteriology · doi:10.1128/jb.01768-14 · Cited by 80 · see citing works

Context-Based Identification of Protein-Protein Interfaces and “Hot-Spot” Residues

Geppert, T., Hoy, B., Wessler, S., & Schneider, G. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.01.005 · Cited by 80 · see citing works

Enteric bacterial proteases in inflammatory bowel disease- pathophysiology and clinical implications

Carroll, I. M. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i43.7531 · Cited by 82 · see citing works

Pathogenesis of Helicobacter pylori Infection

Backert, S., & Clyne, M. (2011) · Helicobacter · doi:10.1111/j.1523-5378.2011.00876.x · Cited by 79 · see citing works

Helicobacter pylori-Derived Outer Membrane Vesicles (OMVs): Role in Bacterial Pathogenesis?

Jarząb, M., Posselt, G., Meisner-Kober, N. C., & Weßler, S. (2020) · Microorganisms · doi:10.3390/microorganisms8091328 · Cited by 79 · see citing works

Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA

Tegtmeyer, N., Moodley, Y., Yamaoka, Y., Pernitzsch, S. R., Schmidt, V., Rivas-Traverso, F., Schmidt, T. P., Rad, R., Yeoh, K. G., Ho, B., et al. (2015) · Molecular Microbiology · doi:10.1111/mmi.13276 · Cited by 78 · see citing works

The Cancer Microbiota: EMT and Inflammation as Shared Molecular Mechanisms Associated with Plasticity and Progression

Vergara, D., Simeone, P., Damato, M., Maffia, M., Lanuti, P., & Trerotola, M. (2019) · Journal of Oncology · doi:10.1155/2019/1253727 · Cited by 77 · see citing works

How Listeria monocytogenes organizes its surface for virulence

Carvalho, F., Sousa, S., & Cabanes, D. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00048 · Cited by 74 · see citing works

The E-Cadherin Cleavage Associated to Pathogenic Bacteria Infections Can Favor Bacterial Invasion and Transmigration, Dysregulation of the Immune Response and Cancer Induction in Humans

Devaux, C. A., Mezouar, S., & Mège, J. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02598 · Cited by 75 · see citing works

Future Perspective for Potential Helicobacter Pylori Eradication Therapies

Debraekeleer, A., & Remaut, H. K. (2018) · Future Microbiology · doi:10.2217/fmb-2017-0115 · Cited by 72 · see citing works

Outer membrane vesicles of Tannerella forsythia: biogenesis, composition, and virulence

Friedrich, V., Grünwald‐Gruber, C., Nimeth, I., Pabinger, S., Sekot, G., Posch, G., Altmann, F., Messner, P., Andrukhov, O., & Schäffer, C. (2015) · Molecular Oral Microbiology · doi:10.1111/omi.12104 · Cited by 70 · see citing works

Alzheimer′s Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae , Other Suspect Pathogens, and the Immune System

Carter, C. J. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/501862 · Cited by 68 · see citing works

Bioavailability and cytotoxicity of Cerium- (IV), Copper- (II), and Zinc oxide nanoparticles to human intestinal and liver cells through food

Li, J., Song, Y., Vogt, R. D., Liu, Y., Luo, J., & Li, T. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134700 · Cited by 66 · see citing works

Molecular methods to investigate adhesion, transmigration, invasion and intracellular survival of the foodborne pathogen Campylobacter jejuni

Backert, S., & Hofreuter, D. (2013) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2013.06.031 · Cited by 66 · see citing works

Chlamydia Trachomatis Secretion of Proteases for Manipulating Host Signaling Pathways

Zhong, G. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00014 · Cited by 64 · see citing works

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to C hlamydia trachomatis

Gloeckl, S., Ong, V. A., Patel, P., Tyndall, J. D. A., Timms, P., Beagley, K. W., ALLAN, J. A. B., Armitage, C. W., Turnbull, L., Whitchurch, C. B., et al. (2013) · Molecular Microbiology · doi:10.1111/mmi.12306 · Cited by 63 · see citing works

Bacterial extracellular vesicles and their interplay with the immune system

Doré, É., & Boilard, É. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108443 · Cited by 61 · see citing works

Campylobacter jejuniserine protease HtrA plays an important role in heat tolerance, oxygen resistance, host cell adhesion, invasion, and transmigration

Boehm, M., Lind, J., Backert, S., & Tegtmeyer, N. (2015) · European Journal of Microbiology and Immunology · doi:10.1556/eujmi-d-15-00003 · Cited by 62 · see citing works

Dynamic Monitoring of Salmonella typhimurium Infection of Polarized Epithelia Using Organic Transistors

Tria, S. A., Ramuz, M. P., Huerta, M., Leleux, P., Rivnay, J., Jimison, L. H., Hama, A., Malliaras, G. G., & Owens, R. M. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201300632 · Cited by 61 · see citing works

Human campylobacteriosis

Backert, S., Tegtmeyer, N., Cróinı́n, T. Ó., Boehm, M., & Heimesaat, M. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803623-5.00001-0 · Cited by 61 · see citing works

Host cell-surface proteins as substrates of gingipains, the main proteases of Porphyromonas gingivalis

Hočevar, K., Potempa, J., & Turk, B. (2018) · Biological Chemistry · doi:10.1515/hsz-2018-0215 · Cited by 60 · see citing works

Pseudomonas aeruginosa ExlA and Serratia marcescens ShlA trigger cadherin cleavage by promoting calcium influx and ADAM10 activation

Reboud, E., Bouillot, S., Patot, S., Béganton, B., Attrée, I., & Huber, P. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006579 · Cited by 60 · see citing works

Helicobacters and cancer, not only gastric cancer?

Varon, C., Martin, L. A., Khalid, S., Seeneevassen, L., Ménard, A., & Spuul, P. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.08.007 · Cited by 58 · see citing works

Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis

Lialios, P., & Alimperti, S. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1506636 · Cited by 62 · see citing works

"Targeted disruption of the epithelial-barrier by Helicobacter pylori"

Wroblewski, L. E., & Peek, R. M. (2011) · Cell Communication and Signaling · doi:10.1186/1478-811x-9-29 · Cited by 58 · see citing works

Current information on the association of Helicobacter pylori with autophagy and gastric cancer

Eslami, M., Yousefi, B., Kokhaei, P., Arabkari, V., & Ghasemian, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28279 · Cited by 58 · see citing works

Old and New Aspects of H. pylori-Associated Inflammation and Gastric Cancer

Dinca, A. L., Meliţ, L. E., & Mărginean, C. O. (2022) · Children · doi:10.3390/children9071083 · Cited by 61 · see citing works

A new approach against Helicobacter pylori using plants and its constituents: A review study

Sankaran, S., Ammanath, A. V., Biswas, R., Anita, B., Sukumaran, S., & Venkidasamy, B. (2022) · Microbial Pathogenesis · doi:10.1016/j.micpath.2022.105594 · Cited by 56 · see citing works

Inhibitors of Helicobacter pylori Protease HtrA Found by ‘Virtual Ligand’ Screening Combat Bacterial Invasion of Epithelia

Löwer, M., Geppert, T., Schneider, P., Hoy, B., Weßler, S., & Schneider, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017986 · Cited by 55 · see citing works

Properties of the HtrA Protease From Bacterium Helicobacter pylori Whose Activity Is Indispensable for Growth Under Stress Conditions

Zarzecka, U., Modrak‐Wójcik, A., Figaj, D., Apanowicz, M., Lesner, A., Bzowska, A., Lipińska, B., Zawilak-Pawlik, A. M., Backert, S., & Skórko‐Glonek, J. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00961 · Cited by 56 · see citing works

The HtrA protease of B orrelia burgdorferi degrades outer membrane protein BmpD and chemotaxis phosphatase CheX

Coleman, J. L., Crowley, J. T., Toledo, A. M., & Benach, J. L. (2013) · Molecular Microbiology · doi:10.1111/mmi.12213 · Cited by 54 · see citing works

HtrA is a major virulence determinant of Bacillus anthracis

Chitlaru, T., Zaide, G., Ehrlich, S., Inbar, I., Cohen, O., & Avigdor Shafferman, C. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07790.x · Cited by 54 · see citing works

Order and disorder in large multi-site docking proteins of the Gab family—implications for signalling complex formation and inhibitor design strategies

Simister, P. C., & Feller, S. M. (2011) · Molecular BioSystems · doi:10.1039/c1mb05272a · Cited by 54 · see citing works

B orrelia burgdorferi BbHtrA degrades host ECM proteins and stimulates release of inflammatory cytokines in vitro

Russell, T. M., Delorey, M. J., & Johnson, B. J. B. (2013) · Molecular Microbiology · doi:10.1111/mmi.12377 · Cited by 53 · see citing works

Impact ofHelicobacter pylorion the healing process of the gastric barrier

Mnich, E., Kowalewicz‐Kulbat, M., Sicińska, P., Hinc, K., Obuchowski, M., Gajewski, A., Moran, A. P., & Chmiela, M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i33.7536 · Cited by 52 · see citing works

Postinfection Irritable Bowel Syndrome

Downs, I. A., Aroniadis, O. C., Kelly, L., & Brandt, L. J. (2017) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000924 · Cited by 52 · see citing works

L yme disease spirochaetes possess an aggrecan‐binding protease with aggrecanase activity

Russell, T. M., & Johnson, B. J. B. (2013) · Molecular Microbiology · doi:10.1111/mmi.12276 · Cited by 50 · see citing works

Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?

Weßler, S., Schneider, G., & Backert, S. (2017) · Cell Communication and Signaling · doi:10.1186/s12964-017-0162-5 · Cited by 50 · see citing works

Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori

Harrer, A., Boehm, M., Backert, S., & Tegtmeyer, N. (2017) · Gut Pathogens · doi:10.1186/s13099-017-0189-6 · Cited by 50 · see citing works

Fragment‐Based De Novo Design Reveals a Small‐Molecule Inhibitor of Helicobacter Pylori HtrA

Perna, A. M., Rodrigues, T., Schmidt, T. P., Böhm, M., Stutz, K., Reker, D., Pfeiffer, B., Altmann, K., Backert, S., Weßler, S., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201504035 · Cited by 49 · see citing works

Role of Abl and Src family kinases in actin-cytoskeletal rearrangements induced by the Helicobacter pylori CagA protein

Tegtmeyer, N., & Backert, S. (2011) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.11.006 · Cited by 48 · see citing works

HtrA-mediated E-cadherin cleavage is limited to DegP and DegQ homologs expressed by gram-negative pathogens

Abfalter, C. M., Schubert, M., Goetz, C., Schmidt, T. P., Posselt, G., & Weßler, S. (2016) · Cell Communication and Signaling · doi:10.1186/s12964-016-0153-y · Cited by 48 · see citing works

Implications of the Human Gut–Brain and Gut–Cancer Axes for Future Nanomedicine

Javed, I., Cui, X., Wang, X., Mortimer, M., Andrikopoulos, N. K., Li, Y., Davis, T. P., Zhao, Y., Ke, P. C., & Chen, C. (2020) · ACS Nano · doi:10.1021/acsnano.0c07258 · Cited by 47 · see citing works

Lipopolysaccharide Increases the Incidence of Collagen‐Induced Arthritis in Mice Through Induction of Protease HTRA‐1 Expression

Hou, Y., Lin, H., Zhu, L., Liu, Z., Hu, F., Shi, J., Yang, T., Shi, X., Zhu, M., Godley, B. F., et al. (2013) · Arthritis & Rheumatism · doi:10.1002/art.38124 · Cited by 47 · see citing works

HtrA Is Important for Stress Resistance and Virulence in Haemophilus parasuis

Zhang, L., Li, Y., Wen, Y., Lau, G. W., Huang, X., Wu, R. J., Yan, Q., Huang, Y., Zhao, Q., Ma, X., et al. (2016) · Infection and Immunity · doi:10.1128/iai.00147-16 · Cited by 47 · see citing works

Why can’t we make an effective vaccine againstHelicobacter pylori?

SUTTON, P. R. N., & Chionh, Y. T. (2013) · Expert Review of Vaccines · doi:10.1586/erv.13.20 · Cited by 47 · see citing works

Bacterial extracellular vesicles – brain invaders? A systematic review

Kaisanlahti, A., Salmi, S., Kumpula, S., Amatya, S. B., Turunen, J., Tejesvi, M. V., Byts, N., Tapiainen, T., & Reunanen, J. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1227655 · Cited by 46 · see citing works

Adherens junctions as targets of microorganisms: A focus on Helicobacter pylori

Costa, Â. M., Leite, M., Seruca, R., & Figueiredo, C. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.12.008 · Cited by 46 · see citing works

Virtual screening of active compounds from Artemisia argyi and potential targets against gastric ulcer based on Network pharmacology

Wang, Y., Sun, Y., Wang, Y., Ju, Y., & Meng, D. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.102924 · Cited by 46 · see citing works

Thermosensing to Adjust Bacterial Virulence in a Fluctuating Environment

Steinmann, R., & Dersch, P. (2012) · Future Microbiology · doi:10.2217/fmb.12.129 · Cited by 44 · see citing works

Activities of muscadine grape skin and polyphenolic constituents againstHelicobacter pylori

Brown, J., & Jiang, X. (2013) · Journal of Applied Microbiology · doi:10.1111/jam.12129 · Cited by 43 · see citing works

Colibactin-producing Escherichia coli enhance resistance to chemotherapeutic drugs by promoting epithelial to mesenchymal transition and cancer stem cell emergence

Dalmasso, G., Cougnoux, A., Faïs, T., Bonnin, V., Mottet-Auselo, B., Nguyen, H. T. T., Sauvanet, P., Barnich, N., Jary, M., Pezet, D., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2310215 · Cited by 43 · see citing works

Comparative Genomics of Helicobacter pylori and the human-derived Helicobacter bizzozeronii CIII-1 strain reveal the molecular basis of the zoonotic nature of non-pylori gastric Helicobacter infections in humans

Schott, T., Kondadi, P. K., Hänninen, M., & Rossi, M. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-534 · Cited by 42 · see citing works

Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA.

Schmidt, T. P., Perna, A. M., Fugmann, T., Böhm, M., Hiss, J. A., Haller, S., Goetz, C., Tegtmeyer, N., Hoy, B., Rau, T., et al. (2016) · Open Access CRIS of the University of Bern · doi:10.7892/boris.92059

E-Cadherin Orthologues as Substrates for the Serine Protease High Temperature Requirement A (HtrA)

Bernegger, S., Hutterer, E., Zarzecka, U., Schmidt, T. P., Huemer, M., Widlroither, I., Posselt, G., Skórko‐Glonek, J., & Weßler, S. (2022) · Biomolecules · doi:10.3390/biom12030356 · Cited by 7 · see citing works

Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin

Hoy, B., Geppert, T., Boehm, M., Reisen, F., Plattner, P., Gadermaier, G., Sewald, N., Ferreira, F., Briza, P., Schneider, G., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.c111.333419 · Cited by 171 · see citing works

Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells

Bernegger, S., Vidmar, R., Fonovič, M., Posselt, G., Turk, B., & Weßler, S. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00788-x · Cited by 24 · see citing works

Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori

Harrer, A., Boehm, M., Backert, S., & Tegtmeyer, N. (2017) · Gut Pathogens · doi:10.1186/s13099-017-0189-6 · Cited by 50 · see citing works