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Cited by 42Liver physiology and pathologyDrug-Induced Hepatotoxicity and ProtectionOrgan Transplantation Techniques and Outcomes

The DOI matches its Crossref record.

Continuous hepatocyte growth factor supply prevents lipopolysaccharide‐induced liver injury in rats

Kaido, Toshimi, Yamaoka, Shoji, Seto, Shin-ichi, Funaki, Naomi, Kasamatsu, Takayuki, Tanaka, Junji, Nakamura, Toshikazu, Imamura, Masayuki·1997·FEBS Letters
DOI 10.1016/s0014-5793(97)00744-8
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Abstract

We present a rat model in which continuous supply of hepatocyte growth factor (HGF) prevents liver injury induced by carbon tetrachloride (CCl4) and E. coli 011:B4 lipopolysaccharide (LPS). Rat fibroblasts genetically modified to secrete rat HGF were implanted in syngenic rat spleen 7 days before administration of the hepatotoxins. Rats with HGF-secreting fibroblasts in the spleen showed a dramatic resistance to CCl4- and LPS-induced liver injury. In the LPS-induced liver injury model, blood chemical analysis revealed that the increase in serum glutamic oxalacetic transaminase level and the decrease in blood sugar level were remarkably suppressed in rats with HGF-secreting cells in the spleen. Most importantly, their survival rate was greatly improved compared to other control groups of rats. Thus our results indicate a new role of HGF in liver protection during endotoxemia and convey important clinical implications for developing new therapeutic modalities in the treatment of liver failure caused by endotoxemia.

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Crossref · 10.1016/s0014-5793(97)00744-8

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  • Continuous introduction of rat HGF to animals through genetically modified fibroblasts significantly decreased liver injury following LPS injection.

    “when Kaido et al. continuously introduced rat HGF to animals through genetically modified fibroblasts, there was a significantly decreased liver injury following LPS injection [31].”

    From Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli (2014) · cites this paper as [31]

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Metadata

Authors
Kaido, T., Yamaoka, S., Seto, S.-I., Funaki, N., Kasamatsu, T., Tanaka, J., Nakamura, T., & Imamura, M.
Affiliations
  • Kyoto University (JP)
  • The University of Osaka (JP)
Corresponding author
Yamaoka, Shoji
ORCID
Venue
FEBS Letters
Publisher
Wiley
Published
1997-07-14
Volume
411
Issue
2-3
Pages
378-382
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
DOI
10.1016/s0014-5793(97)00744-8
OpenAlex
W2114726053
Cited by
42
References
0
Citations by year
2025: 1 · 2021: 1 · 2017: 3 · 2016: 1 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
3.04
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1249 d)
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords
hepatocyte growth factor, lipopolysaccharide, endotoxemia, liver injury, carbon tetrachloride, hepatoprotection, liver failure, aspartate aminotransferase, blood glucose
MeSH terms
Alanine Transaminase, Animals, Aspartate Aminotransferases, Carbon Tetrachloride, Endotoxins, Fibroblasts, Humans, Lipopolysaccharides, Liver, Male, Rats, Inbred F344, Recombinant Proteins, Spleen, Hepatocyte Growth Factor, Cell Transplantation, Endotoxemia, Rats

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