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Tissue‐dependent upregulation of rat uncoupling protein‐2 expression in response to fasting or cold
Open accessAbstract
The control of uncoupling protein‐2 (UCP2) mRNA expression in rat brown adipose tissue (BAT), heart and skeletal muscles was examined. Cold exposure (48 h) increased UCP2 mRNA in BAT, heart and soleus muscle by 2.4‐, 4.3‐ and 2.6‐fold, respectively. Fasting (48 h) had no effect on UCP2 mRNA expression neither in BAT nor in heart, but markedly increased it in skeletal muscles. While the upregulation of UCP2 mRNA in response to cold exposure is in line with a putative uncoupling role for this protein in thermoregulatory thermogenesis, the unexpected upregulation of UCP2 in skeletal muscles in response to fasting seems inconsistent with its role as an uncoupling protein involved in dietary regulation of thermogenesis.
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Citations
Cited by
Towards a molecular understanding of adaptive thermogenesis
Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630
Uncoupling: new approaches to an old problem of bioenergetics
Skulachev, V. P. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(97)00091-1 · Cited by 893
Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3
Brand, M. D., & Esteves, T. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.002 · Cited by 785
Nedergaard, J., Golozoubova, V., Matthias, A., Asadi, A., Jacobsson, A., & Cannon, B. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00247-4 · Cited by 615
Obesity Induces Expression of Uncoupling Protein-2 in Hepatocytes and Promotes Liver ATP Depletion
Chavin, K. D., Yang, S., Lin, H. Z., Chatham, J., Chacko, V. P., Hoek, J. B., Walajtys-Rode, E., Rashid, A., Chen, C.-H., Huang, C.-C., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.9.5692 · Cited by 441
Metadata
- Authors
- Boss, O., Samec, S., Dulloo, A., Seydoux, J., Muzzin, P., & Giacobino, J.-P.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1997-07-21
- Volume
- 412
- Issue
- 1
- Pages
- 111-114
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2164982575
- Cited by
- 218
- References
- 0
- FWCI
- 15.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Boss, O., Samec, S., Dulloo, A., Seydoux, J., Muzzin, P., & Giacobino, J.-P. (1997). Tissue‐dependent upregulation of rat uncoupling protein‐2 expression in response to fasting or cold. FEBS Letters. https://doi.org/10.1016/s0014-5793(97)00755-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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