The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification
Open accessAbstract
Human serum paraoxonase (PON1) associated with high density lipoprotein (HDL) has been postulated to have a role in protecting low density lipoprotein (LDL) against oxidative modification, which has led to the proposal that PON1 is an anti‐atherogenic, anti‐inflammatory enzyme. PON1 has two genetically determined polymorphic sites giving rise to amino‐acid substitutions at positions 55 (L→M) and 192 (R→Q) and therefore 4 potential alloenzymes. We have examined the effects of these molecular polymorphisms on the ability of HDL to protect LDL from oxidative modification. HDL protected LDL from oxidative modification, whatever the combination of PON1 alloenzymes present in it. However, HDL from QQ/MM homozygotes was most effective at protecting LDL while HDL from RR/LL homozygotes was least effective. Thus after 6 h of co‐incubation of HDL and LDL with Cu 2+PON1‐QQ HDL retained 57±6.3% of its original ability to protect LDL from oxidative modification, while PON1‐QR HDL retained less at 25.1±4.5% (P<0.01) and PON1‐RR HDL retained only 0.75±0.40% (P<0.005). In similar experiments HDL from LL and LM genotypes retained 21.8±7.5% and 29.5±6.6% (P=NS), respectively, of their protective ability, whereas PON1‐MM HDL maintained 49.5±5.3% (P<0.01). PON1 polymorphisms may affect the ability of HDL to impede the development of atherosclerosis and to prevent inflammation.
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Cites
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Paraoxonase prevents accumulation of lipoperoxides in low‐density lipoprotein
Mackness, M. I., Arrol, S., & Durrington, P. N. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80962-3 · Cited by 977
Self-citationThe molecular basis of the human serum paraoxonase activity polymorphism
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MACKNESS, M., ARROL, S., ABBOTT, C., & DURRINGTON, P. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90183-u · Cited by 816
Self-citationThe effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin
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HDL, its enzymes and its potential to influence lipid peroxidation
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Self-citationWatson, A. D., Navab, M., Hama, S. Y., Sevanian, A., Prescott, S. M., Stafforini, D. M., McIntyre, T. M., Du, B. N., Fogelman, A. M., & Berliner, J. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117726 · Cited by 403
Cited by
Scott, S. A., Sangkuhl, K., Stein, C. M., Hulot, J.-S., Mega, J. L., Roden, D. M., Klein, T. E., Sabatine, M. S., Johnson, J. A., & Shuldiner, A. R. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2013.105 · Cited by 962
Navab, M., Hama, S. Y., Anantharamaiah, G. M., Hassan, K., Hough, G. P., Watson, A. D., Reddy, S. T., Sevanian, A., Fonarow, G. C., & Fogelman, A. M. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33462-3 · Cited by 668
Mackness, B., Davies, G. K., Turkie, W., Lee, E., Roberts, D. H., Hill, E., Roberts, C., Durrington, P. N., & Mackness, M. I. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/hq0901.094247 · Cited by 435
Self-citationCosta, L. G., Cole, T. B., Jarvik, G. P., & Furlong, C. E. (2003) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152421 · Cited by 264
Air pollution and circulating biomarkers of oxidative stress
Delfino, R. J., Staimer, N., & Vaziri, N. D. (2011) · Air Quality, Atmosphere & Health · doi:10.1007/s11869-010-0095-2 · Cited by 181
Metadata
- Authors
- Mackness, B., Mackness, M. I., Arrol, S., Turkie, W., & Durrington, P. N.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1998-02-13
- Volume
- 423
- Issue
- 1
- Pages
- 57-60
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1997801947
- Cited by
- 377
- References
- 20
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mackness, B., Mackness, M. I., Arrol, S., Turkie, W., & Durrington, P. N. (1998). Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification. FEBS Letters. https://doi.org/10.1016/s0014-5793(98)00064-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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