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Yeast putative transcription factors involved in salt tolerance
Open accessAbstract
Four putative yeast transcription factors (Hal6–9p) have been identified which upon overexpression in multicopy plasmids increase sodium and lithium tolerance. This effect is mediated, at least in part, by increased expression of the Ena1p Na+/Li+ extrusion pump. Hal6p and Hal7p are bZIP proteins and their gene disruptions affected neither salt tolerance nor ENA1 expression. Hal8p and Hal9p are putative zinc fingers and their gene disruptions decreased both salt tolerance and ENA1 expression. Therefore, Hal8p and Hal9p, but not Hal6p and Hal7p, qualify as transcriptional activators of ENA1 under physiological conditions. Hal8p seems to mediate the calcineurin‐dependent part of ENA1 expression.
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“Calcineurin-dependent expression of these genes is regulated by the ScCrz1/Tcn1/Hal8 transcription factor (Stathopoulos and Cyert 1997;Matheos et al. 1997;Mendizabal et al. 1998)”
From Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor (2005) · cites this paper as Mendizabal et al. 1998
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Metadata
- Authors
- Mendizabal, I., Rios, G., Mulet, J. M., Serrano, R., & de Larrinoa, I. F.
- Affiliations
- Instituto de Biología Molecular y Celular de Plantas (ES)
- Corresponding author
- Serrano, Ramón
- ORCID
- Serrano, Ramón
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1998-03-27
- Volume
- 425
- Issue
- 2
- Pages
- 323-328
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1992992274
- Cited by
- 136
- References
- 23
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 4
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- yeast, salt tolerance, sodium tolerance, lithium tolerance, transcription factors, ENA1, bZIP transcription factors, zinc finger proteins, calcineurin, transcriptional activation, gene disruption
- MeSH terms
- Adaptation, Physiological, Adenosine Triphosphatases, Sodium-Potassium-Exchanging ATPase, Amino Acid Sequence, Cell Division, Chromosome Mapping, Culture Media, DNA-Binding Proteins, Fungal Proteins, Lithium, Molecular Sequence Data, Saccharomyces cerevisiae, Sodium, Transcription Factors, Gene Expression Regulation, Fungal, Leucine Zippers, Cation Transport Proteins, Saccharomyces cerevisiae Proteins
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