The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

Mendoza, I.; Rubio, F.; Rodriguez-Navarro, A.; Pardo, J.M.

doi:10.1016/s0021-9258(17)37038-2

Cited by 355Fungal and yeast genetics researchSignaling Pathways in DiseaseBacterial Genetics and Biotechnology

The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

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Mendoza, I., Rubio, F., Rodriguez-Navarro, A., Pardo, J.M.·1994·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(17)37038-2

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Abstract

NaCl-sensitive yeast mutants were isolated to identify genes essential for NaCl tolerance. Complementation of a mutant highly sensitive to Na+ and Li+ led to the isolation of the CNB1 gene. This gene encodes the regulatory subunit (CNB) of the Ca2+/calmodulin-dependent protein phosphatase calcineurin. Cells deficient in CNB accumulated Li+ due to reduced expression of ENA1, a gene encoding a P-type ATPase involved in Na+ and Li+ efflux. In addition, the K+ transport system of cnb1 delta cells was not converted to the high affinity state that facilitates better discrimination of K+ over Na+. Thus the cnb1 delta strain resembled a trk1 mutant. These results indicate that adaptation to NaCl stress in Saccharomyces cerevisiae requires a signal transduction pathway involving Ca2+ and protein phosphorylation-dephosphorylation. In this pathway, calcineurin would coordinate gene expression and activity of ion transporters to facilitate ion homeostasis.

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S. cerevisiae cells lacking calcineurin are hypersensitive to Na+, Li+, Mn2+ and hydroxyl ions.
“However, S. cerevisiae cells lacking this phosphatase are hypersensitive to some ions including Na + , Li + , Mn 2+ and hydroxyl ions (Nakamura et al. 1993;Breuder et al. 1994;Mendoza et al. 1994;Farcasanu et al. 1995)”
From Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor (2005) · cites this paper as Mendoza et al. 1994
Calcineurin is required for NaCl and LiCl tolerance in S. cerevisiae.
“The requirement of calcineurin for NaCl and LiCl tolerance in S. cerevisiae was demonstrated wherein the cnb1 mutant accumulated high levels of lithium as a consequence of decrease in the expression of the ENA1 gene and failure in K+ transport system (Mendoza et al., 1994).”
From Calcineurin as a multifunctional regulator: Unraveling novel functions in fungal stress responses, hyphal growth, drug resistance, and pathogenesis (2014) · cites this paper as Mendoza et al., 1994

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Authors: Mendoza, I., Rubio, F., Rodriguez-Navarro, A., & Pardo, J. M.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
ORCID: Mendoza, I.
Rubio, F.
Pardo, J.M.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1994-03
Volume: 269
Issue: 12
Pages: 8792-8796
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(17)37038-2
OpenAlex: W1587918801
Semantic Scholar: 03506f73fdcb61ede7c6c76f8d244bbac6fb382e
Cited by: 350
References: 32
Citations by year: 2025: 2 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 9 · 2013: 8 · 2012: 2
FWCI: 7.68
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 9735 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: calcineurin, NaCl tolerance, salt stress, Saccharomyces cerevisiae, ENA1, P-type ATPase, lithium accumulation, ion homeostasis, potassium transport, Trk1, Ca2+/calmodulin signaling, protein phosphorylation, gene essentiality
MeSH terms: Adenosine Triphosphatases, Sodium-Potassium-Exchanging ATPase, Base Sequence, Biological Transport, Active, Calmodulin-Binding Proteins, Chromosome Mapping, Cloning, Molecular, Fungal Proteins, Genes, Fungal, Genetic Complementation Test, Homeostasis, Molecular Sequence Data, Phosphoprotein Phosphatases, Saccharomyces cerevisiae, Sodium, Sodium Chloride, Water-Electrolyte Balance, Restriction Mapping, Lithium Chloride, Calcineurin, Cation Transport Proteins, Saccharomyces cerevisiae Proteins

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The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

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