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Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
Open accessAbstract
In the present study, we demonstrate that NLT (novel liver‐specific transport protein) is a multispecific organic anion transporter of the liver. The amino acid sequence of NLT shows 42% identity to that of the renal multispecific organic anion transporter, OAT1. When expressed in Xenopus laevis oocytes, NLT mediated uptake of organic anions, such as salicylate, acetylsalicylate, PGE 2, dicarboxylates and p‐aminohippurate. [14 C]Salicylate uptake via NLT was saturable (K m=88.8±23.4 μM) and sodium‐independent. Expression of the mRNA of NLT was detected in the liver and kidney (liver≫kidney). We propose that NLT be renamed OAT2.
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Citations
Cited by
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Study, L. C., Köttgen, A., CARDIoGRAM Consortium, DIAGRAM Consortium, ICBP Consortium, MAGIC Consortium, Albrecht, E., Teumer, A., Vitart, V., Krumsiek, J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2500 · Cited by 836
Cha, S. H., Sekine, T., Fukushima, J.-I., Kanai, Y., Kobayashi, Y., Goya, T., & Endou, H. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12589-8 · Cited by 508
Self-citationGene Expression Levels and Immunolocalization of Organic Ion Transporters in the Human Kidney
Motohashi, H., Sakurai, Y., Saito, H., Masuda, S., Urakami, Y., Goto, M., Fukatsu, A., Ogawa, O., & Inui, K.-I. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v134866 · Cited by 508
Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
Dobson, P. D., & Kell, D. B. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2438 · Cited by 475
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Mizuno, N., Niwa, T., Yotsumoto, Y., & Sugiyama, Y. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.1 · Cited by 490
Metadata
- Authors
- Sekine, T., Cha, S. H., Tsuda, M., Apiwattanakul, N., Nakajima, N., Kanai, Y., & Endou, H.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1998-06-12
- Volume
- 429
- Issue
- 2
- Pages
- 179-182
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1996402420
- Cited by
- 335
- References
- 0
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sekine, T., Cha, S. H., Tsuda, M., Apiwattanakul, N., Nakajima, N., Kanai, Y., & Endou, H. (1998). Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Letters. https://doi.org/10.1016/s0014-5793(98)00585-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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