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The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation
Open accessAbstract
Transforming growth factor‐β (TGF‐β) and bone morphogenetic proteins (BMPs) signal via distinct type I and type II receptors and Smad proteins. A nine amino acid sequence between kinase subdomains IV and V in type I receptors, termed the L45 loop, has been shown to be important in conferring signalling specificity. We examined the responses of a mutant TGF‐β type I receptor (TβR‐I) and a mutant BMPR‐IB, in which the L45 regions of these two receptors were exchanged. Swapping the four amino acid residues that are different in BMPR‐IB for those in TβR‐I, and vice versa, switched their type I receptor‐restricted Smad activation and specificity in transcriptional responses. These studies identify the L45 loop regions in type I receptors as critical determinants in specifying Smad isoform activation.
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Cited by
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Derynck, R., & Budi, E. H. (2019) · Science Signaling · doi:10.1126/scisignal.aav5183 · Cited by 785
Abnormal angiogenesis but intact hematopoietic potential in TGF‐β type I receptor‐deficient mice
Larsson, J., Goumans, M., Sjöstrand, L. J., van Rooijen, M. A., Ward, D., Levéen, P., Xu, X., ten Dijke, P., Mummery, C. L., & Karlsson, S. (2001) · The EMBO Journal · doi:10.1093/emboj/20.7.1663 · Cited by 563
Self-citationStructural insights into BMP receptors: Specificity, activation and inhibition
Yadin, D., Knaus, P., & Mueller, T. D. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.11.005 · Cited by 221
Smad3 allostery links TGF-β receptor kinase activation to transcriptional control
Qin, B. Y., Lam, S. S., Correia, J. J., & Lin, K. (2002) · Genes & Development · doi:10.1101/gad.1002002 · Cited by 139
Kim, S., Wairkar, Y. P., Daniels, R. W., & DiAntonio, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911126 · Cited by 82
Metadata
- Authors
- Persson, U., Izumi, H., Souchelnytskyi, S., Itoh, S., Grimsby, S., Engström, U., Heldin, C.-H., Funa, K., & ten Dijke, P.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1998-08-28
- Volume
- 434
- Issue
- 1-2
- Pages
- 83-87
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1992374635
- Cited by
- 398
- References
- 0
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation. https://app.cochat.ai/papers/10.1016/s0014-5793(98)00954-5
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- Persson, U., Izumi, H., Souchelnytskyi, S., Itoh, S., Grimsby, S., Engström, U., Heldin, C.-H., Funa, K., & ten Dijke, P. (1998). The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation. FEBS Letters. https://doi.org/10.1016/s0014-5793(98)00954-5
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