Specificity, versatility, and control of TGF-β family signaling

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TGFβ signalling in context

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Smad transcription factorsPreprint

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Ubiquitin modifications

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TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology

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SMAD proteins control DROSHA-mediated microRNA maturation

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TGFβ signalling: a complex web in cancer progression

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

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Akt, FoxO and regulation of apoptosis

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Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism.

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Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin

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Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation

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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

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Latent TGF-β structure and activation

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SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

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Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

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TGF-β Signaling from Receptors to SmadsPreprint

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Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity

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50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

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Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p300

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Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

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Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

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Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

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TGF-β1 Signaling and Tissue Fibrosis

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The world of protein acetylation

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GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

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Integration of TGF‐β/Smad and Jagged1/Notch signalling in epithelial‐to‐mesenchymal transition

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Silencing of TGF-β signalling by the pseudoreceptor BAMBI

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Crystal Structure of a Smad MH1 Domain Bound to DNA

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Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressorPreprint

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High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells

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TGF‐β receptor‐activated p38 MAP kinase mediates Smad‐independent TGF‐β responses

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Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

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Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-β

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Signaling Receptors for TGF-β Family Members

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The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

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Non-Smad Signaling Pathways of the TGF-β FamilyPreprint

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GS domain mutations that constitutively activate T beta R‐I, the downstream signaling component in the TGF‐beta receptor complex.

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TGF‐β induces fibronectin synthesis through a c‐Jun N‐terminal kinase‐dependent, Smad4‐independent pathway

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The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

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The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration

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GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

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A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

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Signaling Cross Talk between TGF-β/Smad and Other Signaling PathwaysPreprint

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TGF-β Family Signaling in the Control of Cell Proliferation and Survival

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Integrating signals from RTKs to ERK/MAPK

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Morphogen Gradients: From Generation to Interpretation

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TGF‐β activates Erk MAP kinase signalling through direct phosphorylation of ShcA

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Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis

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Cell size and invasion in TGF-β–induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway

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Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

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TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

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A Smad Transcriptional Corepressor

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The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

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A Self-Enabling TGFβ Response Coupled to Stress Signaling

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The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

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Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription

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TGF‐β‐induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

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The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activationPreprint

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Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

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TGF-β Family Signaling in Tumor Suppression and Cancer ProgressionPreprint

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FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

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Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis

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PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling

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Non-histone protein methylation as a regulator of cellular signalling and function

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GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3 + regulatory T cells

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Crystal Structure of the Cytoplasmic Domain of the Type I TGF β Receptor in Complex with FKBP12

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Universal GFP reporter for the study of vascular development

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Involvement of the p38 Mitogen-activated Protein Kinase Pathway in Transforming Growth Factor-β-induced Gene Expression

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Crystal Structure of Transforming Growth Factor-β2: an Unusual Fold for the Superfamily

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Regulation of TGF-β Family Signaling by Inhibitory Smads

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Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker

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Transforming Growth Factor-β–induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA

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TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway

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Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

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The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation

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TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3

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Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis

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Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF‐β

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