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PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter
Open accessAbstract
PPARγ is a member of the peroxisome proliferator activated receptors (PPAR) subfamily of nuclear receptors. So far two PPARγ isoforms, PPARγ1 and PPARγ2, were known in mammals. We describe the structure of a novel human PPARγ subtype, PPARγ3. The PPARγ3 mRNA is transcribed from a novel promoter localized 5′ of exon A2. PPARγ3 mRNA expression was restricted to adipose tissue and large intestine. Similar to human PPARγ1 and ‐2, PPARγ3 is activated by thiazolidinediones and prostaglandin J derivatives and binds with high affinity to a PPRE.
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Cited by
The PPARs: From Orphan Receptors to Drug Discovery
Willson, T. M., Brown, P. J., Sternbach, D. D., & Henke, B. R. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990554g · Cited by 1,816
PPARγ, the ultimate thrifty gene
Auwerx, J. (1999) · Diabetologia · doi:10.1007/s001250051268 · Cited by 612
Self-citationPeroxisome proliferator-activated receptors: insight into multiple cellular functions
Escher, P., & Wahli, W. (2000) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(99)00231-6 · Cited by 491
mTOR , metabolism, and the regulation of T‐cell differentiation and function
Waickman, A. T., & Powell, J. D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01152.x · Cited by 420
The role of PPARs in inflammation and immunity
Clark, R. B. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.3.388 · Cited by 337
Metadata
- Authors
- Fajas, L., Fruchart, J.-C., & Auwerx, J.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1998-10-30
- Volume
- 438
- Issue
- 1-2
- Pages
- 55-60
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1843523988
- Cited by
- 336
- References
- 0
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fajas, L., Fruchart, J.-C., & Auwerx, J. (1998). PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter. FEBS Letters. https://doi.org/10.1016/s0014-5793(98)01273-3
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
