Determinants of plasma coenzyme Q10 in humans
Open accessAbstract
In the present study, we assessed the strongest determinants of plasma coenzyme Q10 (Qm10) in 518 men and women (aged 45-70 years) with a stepwise multivariate regression model. Male gender (P<0.001), serum cholesterol (P<0.001), serum gamma-glutamyltransferase (P<0.001), serum triglycerides (P< 0.001), age (P=0.017) and 4-day alcohol consumption (P=0.03) were the most important factors which were directly associated with plasma Q10). The intensity of conditioning exercise (P=0.03) and use of statins (P<0.05) showed an inverse association with plasma Q10. None of the assessed nutrients increased plasma Q10 levels significantly. Our results suggest that many confounding factors, in addition to serum cholesterol and triglycerides, should be taken into account when the role of plasma Q10 is examined in epidemiological research.
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Statin intake can lead to reduced CoQ10 levels.
“As CoQ10 is only supplied in small quantities with food and is predominantly synthesised endogenously,(16,17) statin intake can lead to reduced CoQ10 levels.(17)”
From Effects of coenzyme Q10 supplementation on myopathy in statin-treated patients: a systematic review and meta-analysis (2025) · cites this paper as [17]
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Ghirlanda, G., Oradei, A., Manto, A., Lippa, S., Uccioli, L., Caputo, S., Greco, A. V., & Littarru, G. P. (1993) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1993.tb03948.x · Cited by 324 · see citing works
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- Lucker, P.W., Wetzelsberger, N., Hennings, G. and Rehn, D. (1984) in: Biomedical and Clinical Aspects of Coenzyme Q (Folkers, K. and Yamamura, Y., Eds.) Vol. 4, pp. 143^151, Elsevier, Amsterdam.
- Folkers, K., Langsjoen, P., Willis, R., Richardson, P., Xia, L.J., Ye, C.Q. and Tamagawa, H. (1990) Proc. Natl. Acad. Sci. USA 87, 8931^8934.
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Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations
Bhagavan, H. N., & Chopra, R. K. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.03.003 · Cited by 243 · see citing works
Coenzyme Q10 and statins: Biochemical and clinical implications
Littarru, G. P., & Langsjoen, P. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.03.002 · Cited by 188 · see citing works
Dietary fats, cholesterol and iron as risk factors for Parkinson's disease
Powers, K. M., Smith-Weller, T., Franklin, G. M., Longstreth, W. T., Swanson, P. D., & Checkoway, H. (2009) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2008.03.002 · Cited by 100 · see citing works
Hargreaves, I. P., Duncan, A. J., Heales, S. J. R., & Land, J. M. (2005) · Drug Safety · doi:10.2165/00002018-200528080-00002 · Cited by 91 · see citing works
Derosa, G., D'Angelo, A., & Maffioli, P. (2019) · Drug Design, Development and Therapy · doi:10.2147/dddt.s223153 · Cited by 44 · see citing works
Kovacic, S., Habicht, S. D., & Eckert, G. P. (2025) · Journal of Nutritional Science · doi:10.1017/jns.2025.10043 · Cited by 4 · see citing works
“(15) As CoQ10 is only supplied in small quantities with food and is predominantly synthesised endogenously, (16,17) statin intake can lead to reduced CoQ10 levels.”
- Authors
- Kaikkonen, J., Nyyssönen, K., Tuomainen, T.-P., Ristonmaa, U., & Salonen, J. T.
- Affiliations
- University of Eastern Finland (FI)
- Corresponding author
- Salonen, Jukka T
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-01-29
- Volume
- 443
- Issue
- 2
- Pages
- 163-166
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1972009482
- Cited by
- 97
- References
- 1
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- coenzyme Q10, serum cholesterol, triglycerides, gamma-glutamyl transferase, alcohol consumption, physical activity, statins, confounding factors, middle-aged and older adults, sex differences
- MeSH terms
- Aged, Coenzymes, Female, Humans, Male, Middle Aged, Reference Values, Ubiquinone, Postmenopause
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