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Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin‐activating enzyme complex
Abstract
Sentrin‐1/SUMO‐1 is a novel ubiquitin‐like protein, which can covalently modify a limited number of cellular proteins. Here we report the identification of the sentrin‐activating enzyme complex, which consists of two proteins AOS1 and UBA2. Human AOS1 is homologous to the N‐terminal half of E 1, whereas human UBA2 is homologous to the C‐terminal half of E 1. The human UBA2 gene is located on chromosome 19q12. Human UBA2 could form a β‐mercaptoethanol‐sensitive conjugate with members of the sentrin family, but not with ubiquitin of NEDD8, in the presence of AOS1. Identification of human UBA2 and AOS1 should allow a more detailed analysis of the enzymology of the activation of ubiquitin‐like proteins.
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Cited by
Alquezar, C., Arya, S., & Kao, A. W. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.595532 · Cited by 367
Apg10p, a novel protein‐conjugating enzyme essential for autophagy in yeast
Shintani, T., Mizushima, N., Ogawa, Y., Matsuura, A., Noda, T., & Ohsumi, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5234 · Cited by 269
Sumoylation Silences the Plasma Membrane Leak K+ Channel K2P1
Rajan, S., Plant, L. D., Rabin, M. L., Butler, M. H., & Goldstein, S. A. N. (2005) · Cell · doi:10.1016/j.cell.2005.01.019 · Cited by 263
Kontaxi, C., Piccardo, P., & Gill, A. C. (2017) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2017.00056 · Cited by 138
The Role of Sumoylation in the Response to Hypoxia: An Overview
Filippopoulou, C., Simos, G., & Chachami, G. (2020) · Cells · doi:10.3390/cells9112359 · Cited by 56
Metadata
- Authors
- Gong, L., Li, B., Millas, S., & Yeh, E. T. H.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-04
- Volume
- 448
- Issue
- 1
- Pages
- 185-189
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1999054610
- Cited by
- 179
- References
- 0
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gong, L., Li, B., Millas, S., & Yeh, E. T. H. (1999). Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin‐activating enzyme complex. FEBS Letters. https://doi.org/10.1016/s0014-5793(99)00367-1
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