The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Nitrite reductase activity is a novel function of mammalian mitochondria
Open accessAbstract
Nitrite, which is the major stable degradation product of nitric oxide, exists in all tissues capable of nitric oxide synthesis from L‐arginine. The present study provides experimental evidence that nitrite in contact with respiring mitochondria accepts reducing equivalents from the ubiquinone cycle of the respiratory chain. Univalent reduction of nitrite was totally inhibited by myxothiazol. We therefore conclude on the involvement of redox cycling that ubisemiquinone is associated with the bc 1 complex. Recycling of nitric oxide degradation products via these electron carriers may become a threat to energy‐linked respiration since nitric oxide in direct contact with mitochondria was shown to slow the energy‐linked respiration down and to trigger a mitochondrial source for superoxide radicals. Until now, the existence of nitrite reductase activity was only demonstrated in plants and bacteria. In addition, the present observation elucidates the existence of a nitric oxide synthase‐independent nitric oxide source.
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In the citing paper
“In situations of hypoxia, when the oxygen-dependent NO synthases may become dysfunctional, nitrite reduction is instead greatly enhanced.”
From Nitrate and nitrite in biology, nutrition and therapeutics (2009) · cites this paper as [9]
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In the citing paper
“Sruti Shiva (University of Pittsburgh) reviewed a number of studies demonstrating that components of the respiratory chain can reduce nitrite to NO (refs. 4,9)”
From Nitrate and nitrite in biology, nutrition and therapeutics (2009) · cites this paper as [9]
In the citing paper
“This was later confirmed by Kozlov’s group who illustrated that cytochrome c oxidase was an important regulator of nitrite reduction to NO in the mitochondria [120, 121].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [120]
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Citations
Cites
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Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788
Nitric oxide synthase activity in mitochondria
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Inflammatory responses to ischemia, and reperfusion in skeletal muscle
Gute, D. C., Ishida, T., Yarimizu, K., & Korthius, R. J. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006832207864 · Cited by 252
Zweier, J. L., Wang, P., & Kuppusamy, P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.1.304 · Cited by 244
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Lala, P. K., & Orucevic, A. (1998) · Cancer and Metastasis Reviews · doi:10.1023/a:1005960822365 · Cited by 198
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Role of nitric oxide in mediation of macrophage cytotoxicity and apoptosis
Albina, J. E., & Reichner, J. S. (1998) · Cancer and Metastasis Reviews · doi:10.1023/a:1005904704618 · Cited by 182
Evaluation of the Magnitude and Rate of Nitric Oxide Production from Nitrite in Biological Systems
Samouilov, A., Kuppusamy, P., & Zweier, J. L. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0785 · Cited by 170
Reactive Oxygen and Nitrogen Species Regulate Mitochondrial Ca2+ Homeostasis and Respiration
Richter, C. (1997) · Bioscience Reports · doi:10.1023/a:1027387301845 · Cited by 97
Research works printed but not linked: 1
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Cited by
Sorted by citations
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739
“, complexes of the mitochondrial electron transport chai”
BackgroundMethods to detect nitric oxide and its metabolites in biological samples
Bryan, N. S., & Grisham, M. B. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.04.026 · Cited by 1,005
“The nitrite reductase activity in mammalian tissues has been linked to the mitochondrial electron transport system [17-21], protonation [16,22], deoxyhemoglobin [22,23], and xanthine oxidase [24-26].”
BackgroundNitric oxide signaling in health and disease
Lundberg, J. O., & Weitzberg, E. (2022) · Cell · doi:10.1016/j.cell.2022.06.010 · Cited by 879
Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans
Larsen, F. J., Schiffer, T. A., Borniquel, S., Sahlin, K., Ekblom, B., Lundberg, J. O., & Weitzberg, E. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.004 · Cited by 689
“152 Cell Metabolism 13, 149–159, February 2, 2011 a2011 Elsevier In Nitrite is reduced to NO by mitochondria mainly under hypoxia (Kozlov et al., 1999), which also could explain the absence of effect on the respiratory parameters.”
BackgroundInfluentialEffects of dietary nitrate on oxygen cost during exercise
Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01713.x · Cited by 637
“Another possible pathway includes NO formation by the mitochondria themselves (Kozlov et al. 1999) or even simple acidic reduction of nitrite in the working muscle (Zweier et al.”
Background
Metadata
- Authors
- Kozlov, A. V., Staniek, K., & Nohl, H.
- Affiliations
- University of Veterinary Medicine Vienna (AT)
- Corresponding author
- Nohl, Hans
- ORCID
- Kozlov, Andrey V
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-07-02
- Volume
- 454
- Issue
- 1-2
- Pages
- 127-130
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2149980494
- Cited by
- 342
- References
- 14
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 9 · 2019: 15 · 2018: 11 · 2017: 16 · 2016: 14 · 2015: 22 · 2014: 15 · 2013: 9 · 2012: 17
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Keywords
- nitrite reductase, mitochondria, nitric oxide degradation, nitrite, bc1 complex, ubisemiquinone, myxothiazol, redox cycling, superoxide, electron transport chain
- MeSH terms
- Animals, Electron Spin Resonance Spectroscopy, Electron Transport, Liver, Mitochondria, Models, Biological, Nitric Oxide, Nitrite Reductases, Cell Respiration, Rats
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