Cited by 170Reproductive Health and ContraceptionOvarian function and disordersHypothalamic control of reproductive hormones

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Use of the novel combined contraceptive vaginal ring NuvaRing for ovulation inhibition

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Mulders, Titia M.T, Dieben, Thom O.M·2001·Fertility and Sterility

DOI 10.1016/s0015-0282(01)01689-2

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Abstract

Objective To assess the effects of the combined contraceptive vaginal ring NuvaRing on ovarian function.Design Randomized, open-label, crossover study.Setting Clinical pharmacology unit.Participant(s) Sixteen healthy female volunteers.Intervention(s) Group 1: one cycle of combined oral contraceptive containing desogestrel (150 microg) and ethinyl estradiol (30 microg) (desogestrel/EE COC), followed by a NuvaRing treatment period. Group 2: NuvaRing treatment period followed by a cycle of desogestrel/EE COC.Main outcome measure(s) Follicular diameter, serum hormone concentrations (follicle-stimulating hormone, 17beta estradiol, luteinizing hormone, and progesterone), and endometrial thickness.Result(s) NuvaRing use for the recommended period of 3 weeks resulted in complete inhibition of ovulation, as assessed by vaginal ultrasound (follicular diameter) and by serum luteinizing hormone and progesterone concentrations. Inhibition of ovulation was maintained for an additional 2 weeks of NuvaRing use. Ovarian suppression between the groups was comparable. Furthermore, ovarian suppression after 3 weeks of NuvaRing use was comparable to that on day 21 of DGS/EE COC intake. NuvaRing was well tolerated.Conclusion(s) NuvaRing completely inhibited ovulation throughout the normal 3-week period and the extended period of use. Ovarian suppression was comparable to that with desogestrel/EE COC.

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Authors: Mulders, T. M. T., & Dieben, T. O. M.
Affiliations: Organon (Netherlands) (NL)
Corresponding author: Dieben, Thom O.M
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 2001-05
Volume: 75
Issue: 5
Pages: 865-870
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/s0015-0282(01)01689-2
OpenAlex: W2158600879
Cited by: 170
References: 5
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 11 · 2019: 4 · 2018: 4 · 2017: 9 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 7
FWCI: 15.77
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7696 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: NuvaRing, vaginal ring, combined oral contraceptives, ovulation inhibition, ovarian suppression, desogestrel, ethinyl estradiol, follicle-stimulating hormone, luteinizing hormone, follicle size, endometrial thickness
MeSH terms: Adolescent, Adult, Contraceptive Devices, Female, Contraceptives, Oral, Synthetic, Endometrium, Ethinyl Estradiol, Female, Follicle Stimulating Hormone, Ovarian Follicle, Humans, Luteinizing Hormone, Ovulation, Progesterone, Time Factors, Ultrasonography, Vinyl Compounds, Desogestrel, Cross-Over Studies, Estradiol Congeners

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Use of the novel combined contraceptive vaginal ring NuvaRing for ovulation inhibition

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