Aromatase Inhibition Improves Ovarian Response to FSH: A Potential Option for Low Responders During Ovarian Stimulation.
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In women known to be poor responders to FSH stimulation, addition of letrozole to the stimulation protocol resulted in a significant increase in the number of mature follicles at midcycle (3.5 vs. 1.9).
“In these women, addition of letrozole to the stimulation protocol resulted in a significant increase in the number of mature follicles at midcycle (3.5 vs. 1.9).”
From A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal women (2002) · cites this paper as [25]
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Fisher, S. A., Reid, R. L., Van Vugt, D. A., & Casper, R. F. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03241-7 · Cited by 347 · see citing works
Self-citationBosdou, J. K., Venetis, C. A., Kolibianakis, E. M., Toulis, K. A., Goulis, D. G., Zepiridis, L., & Tarlatzis, B. C. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr051 · Cited by 141 · see citing works
Aromatase inhibitors for the treatment of infertility
Mitwally, M. F., & Casper, R. F. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.3.353 · Cited by 120 · see citing works
Self-citationThe management of infertility associated with polycystic ovary syndrome
Homburg, R. (2003) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-1-109 · Cited by 87 · see citing works
Ovulation induction in perspective
Homburg, R. (2002) · Human Reproduction Update · doi:10.1093/humupd/8.5.449 · Cited by 83 · see citing works
“It has been shown to be effective, in early trials, in inducing ovulation and pregnancy in women with anovulatory PCOS and inadequate clomiphene response (Mitwally and Casper, 2001a) and improving ovarian response to FSH in poor responders (Mitwally and Casper, 2001b).”
BackgroundHomburg, R. (2004) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2004.05.006 · Cited by 83 · see citing works
Mitwally, M. F., Casper, R. F., & Diamond, M. P. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-54 · Cited by 55 · see citing works
Self-citationIs ovulation induction still a therapeutic problem in patients with polycystic ovary syndrome?
Palomba, S., Orio, F., Russo, T., Falbo, A. I., Cascella, T., Colao, A. A. L., Lombardi, G., & Zullo, F. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03347527 · Cited by 29 · see citing works
Kahraman, A., & Tülek, F. (2022) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-022-06676-0 · Cited by 7 · see citing works
Clomiphene Citrate versus Letrozole for Ovulation Induction in PCOS: A Comparative Study
Nambiar, S. S. (2018) · Journal of South Asian Federation of Obstetrics and Gynaecology · doi:10.5005/jp-journals-10006-1631 · Cited by 5 · see citing works
Ovulation induction for women with polycystic ovary syndrome
Homburg, R. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545191.010 · Cited by 2 · see citing works
Kahraman, A., & Tülek, F. (2022) · Research Square · doi:10.21203/rs.3.rs-1267736/v1
- Authors
- Mitwally, M. F., & Casper, R. F.
- Affiliations
- Mount Sinai Hospital (CA)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 75
- Issue
- 4
- Pages
- S8-S9
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1976803676
- Cited by
- 12
- References
- 0
- Citations by year
- 2022: 2 · 2018: 1 · 2012: 1
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- letrozole, aromatase inhibitors, poor ovarian responders, FSH stimulation, intrauterine insemination, unexplained infertility, estrogen negative feedback, estradiol, mature follicles, gonadotropin dose reduction, hCG trigger, clomiphene citrate, growth hormone
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