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Cited by 273Endometriosis Research and TreatmentGynecological conditions and treatmentsUterine Myomas and Treatments

The DOI matches its Crossref record; 24 of the 25 references it cites were found in a registry or an index.

Magnetic resonance imaging and transvaginal ultrasonography for the diagnosis of adenomyosis

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Dueholm, Margit, Lundorf, Erik, Hansen, Estrid S, Sørensen, Joan Solgård, Ledertoug, Susanne, Olesen, Frede·2001·Fertility and Sterility
DOI 10.1016/s0015-0282(01)01962-8
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Abstract

Objective To compare the diagnostic potential of magnetic resonance imaging (MRI) and transvaginal ultrasonography (TVS) in the diagnosis of adenomyosis.Design Double blind set-up.Setting University medical school.Patient(s) We studied 106 consecutive premenopausal women who underwent hysterectomy for benign reasons.Intervention(s) Transvaginal ultrasonography and MRI were compared with histopathologic examination as the golden standard.Main outcome measure(s) Adenomyosis.Result(s) Twenty-two (21%) patients had adenomyosis. The sensitivity and specificity were as follows: sensitivity: MRI 0.70 (0.46-0.87) and TVS 0.68 (0.44-0.86) (P=.66); specificity: MRI 0.86 (0.76-0.93) and TVS 0.65 (0.50-0.77) (P=.03). The combination of MRI and TVS was most sensitive (0.89 [0.64-0.98]), but produced the lowest specificity (0.60 [0.44-0.73]). Adenomyosis was not detected by either MRI or TVS at uterine volumes >400 mL. Exclusion of uteri >400 mL from the analysis improved the diagnostic precision of MRI, but not that of TVS. The diagnostic accuracy at MRI was improved by calculating the maximum difference between the thinnest and thickest junctional zone (JZdif) (i.e., > or =5-7 mm).Conclusion(s) Magnetic resonance imaging was superior to TVS for the diagnosis of adenomyosis. Magnetic resonance imaging had a higher specificity than TVS, but their sensitivities were in line. The diagnostic accuracy of MRI, as that of TVS, was at an intermediate level, but the diagnostic accuracy of the former improved by exclusion of uteri >400 mL. The combination of MRI and TVS produced the highest level of accuracy for exclusion of adenomyosis, but the low specificity may necessitate further investigation of positive findings. Measurement of the difference in junctional zone thickness may optimize the diagnosis of adenomyosis at MRI.

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Crossref · 10.1016/s0015-0282(01)01962-8

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Research works printed but not linked: 1

  1. Haines TJ, Tailor HB. Obstetrics and Gynecologic Pathology. 4th Ed. Philadelphia: J.B. Lippincott, 1995:613–5.

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Metadata

Authors
Dueholm, M., Lundorf, E., Hansen, E. S., Sørensen, J. S., Ledertoug, S., & Olesen, F.
Affiliations
Aarhus University (DK)
Corresponding author
Dueholm, Margit
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2001-09
Volume
76
Issue
3
Pages
588-594
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/s0015-0282(01)01962-8
OpenAlex
W1966951938
Cited by
273
References
25
Citations by year
2026: 7 · 2025: 9 · 2024: 10 · 2023: 13 · 2022: 15 · 2021: 16 · 2020: 13 · 2019: 22 · 2018: 10 · 2017: 10 · 2016: 13 · 2015: 15 · 2014: 15 · 2013: 9 · 2012: 12
FWCI
3.22
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
Keywords
adenomyosis, magnetic resonance imaging, transvaginal ultrasound, diagnostic accuracy, sensitivity and specificity, uterine volume, premenopausal women, hysterectomy, histopathological diagnosis
MeSH terms
Adult, Double-Blind Method, Endometriosis, Female, Humans, Hysterectomy, Magnetic Resonance Imaging, Middle Aged, Myometrium, Sensitivity and Specificity, Ultrasonography, Vagina, Reproducibility of Results, Observer Variation, Premenopause

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