Structural abnormalities of the uterine wall in women with endometriosis and infertility visualized by vaginal sonography and magnetic resonance imaging
Abstract
In women with endometriosis, the peristaltic activity of the uterus is significantly enhanced and may even become dysperistaltic at midcycle. Since uterine peristalsis is confined to the endometrium and the subendometrial myometrium with its predominantly circular arrangement of muscular fibres it was assumed that this dysfunction might be associated with structural abnormalities that could be visualized by high resolution ultrasonography and magnetic resonance imaging (MRI). Therefore, the uteri of women with and without endometriosis were subjected to endovaginal sonography (EVS) and to MRI. In EVS, women with laparoscopically proven endometriosis and infertility exhibited an infiltrative expansion of the archimetra in that the halo surrounding the uterine endometrium and representing the subendometrial myometrium was significantly enlarged compared with controls. The expansion was more pronounced in older than in younger women. There was, however, no relationship between the width of the expansion and the severity of the endometriotic disease. Similar data were obtained by MRI in that the 'junctional zone' in women with endometriosis and infertility was expanded in comparison with controls. The results of this study provide further support to the notion that endometriosis is primarily a uterine disease.
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There is a significant association of pelvic endometriosis with uterine adenomyosis in women and in the baboon with life-long infertility.
“There is a significant association of pelvic endometriosis with uterine adenomyosis in women and in the baboon with life-long infertility.”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [22]
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Self-citation
- Authors
- Kunz, G., Beil, D., Huppert, P., & Leyendecker, G.
- Affiliations
- Klinikum Darmstadt (DE)
- ORCID
- Kunz, G.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01
- Volume
- 15
- Issue
- 1
- Pages
- 76-82
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W1992014827
- Cited by
- 177
- References
- 44
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 10 · 2022: 10 · 2021: 6 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 13 · 2016: 8 · 2015: 11 · 2014: 9 · 2013: 5 · 2012: 2
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometriosis, infertility, uterine peristalsis, junctional zone, endovaginal sonography, magnetic resonance imaging, uterine diseases
- MeSH terms
- Adult, Endometriosis, Estradiol, Female, Ovarian Follicle, Humans, Infertility, Female, Magnetic Resonance Imaging, Myometrium, Progesterone, Ultrasonography, Uterus, Vagina
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