The value of a single serum progesterone measurement in the midluteal phase as a criterion of a potentially fertile cycle (“ovulation”) derived from treated and untreated conception cycles

Hull, Michael G.R.; Savage, Philip E.; Bromham, David R.; Ismail, Adel A.A.; Morris, Audrey F.

doi:10.1016/s0015-0282(16)46095-4

Cited by 181Ovarian function and disordersReproductive Health and TechnologiesReproductive Biology and Fertility

The value of a single serum progesterone measurement in the midluteal phase as a criterion of a potentially fertile cycle (“ovulation”) derived from treated and untreated conception cycles

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Hull, Michael G.R., Savage, Philip E., Bromham, David R., Ismail, Adel A.A., Morris, Audrey F.·1982·Fertility and Sterility

DOI 10.1016/s0015-0282(16)46095-4

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Abstract

A single midluteal serum progesterone concentration was obtained in 212 untreated cycles in 113 infertile patients, including 138 cycles in 72 patients in whom tubal, seminal, and cervical causes of infertility had been excluded. There were 16 conception cycles in the latter group. In an extended study a total of 21 untreated singleton conception cycles have been observed with a mean progesterone value of 40.7 nmol/l (12.8 ng/ml), 95% confidence limits of 28 to 53 nmol/l (8.8 to 16.7 ng/ml), and a range of 27 to 53 nmol/l (8.5 to 16.7 ng/ml), which extended significantly above as well as below the conception range, indicating that there is an optimal range for fertility with both an upper and a lower limit. The lower limit is of greater practical importance; and, partly to allow for assay variation, we suggest it should be taken as 30 nmol/l (9.4 ng/ml). It provided a clinically reliable criterion of potential fertility ("ovulation") in related studies. Our findings in treated conception cycles suggest that a higher value may be needed after treatment with clomiphene or gonadotropins because of the contribution from other stimulated follicles.

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Four of the menstruating subjects in the metreleptin arm were determined to be ovulatory, as defined by serum progesterone > 10 ng/mL at the midluteal phase.
“Four of the menstruating subjects in the metreleptin arm were determined to be ovulatory, as de fi ned by serum progesterone > 10 ng/mL at the midluteal phase (18).”
From Leptin is an effective treatment for hypothalamic amenorrhea (2011) · cites this paper as [18]

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Authors: Hull, M. G. R., Savage, P. E., Bromham, D. R., Ismail, A. A. A., & Morris, A. F.
Affiliations: Southmead Hospital (GB)
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 1982-03
Volume: 37
Issue: 3
Pages: 355-360
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/s0015-0282(16)46095-4
OpenAlex: W198308557
Cited by: 178
References: 26
Citations by year: 2026: 2 · 2025: 5 · 2024: 4 · 2023: 11 · 2022: 9 · 2021: 12 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 4
FWCI: 9.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 14697 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords: serum progesterone, mid-luteal phase, ovulation, fertility assessment, infertility, clomiphene citrate, gonadotropin stimulation, follicle stimulation, tubal infertility
MeSH terms: Adult, Body Temperature, Clomiphene, Female, Humans, Infertility, Female, Luteal Phase, Menstruation, Ovulation, Progesterone

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The value of a single serum progesterone measurement in the midluteal phase as a criterion of a potentially fertile cycle (“ovulation”) derived from treated and untreated conception cycles

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