Relationship of luteinizing hormone, pregnanediol-3-glucuronide, and estriol-16-glucuronide in urine of infertile women with endometriosis
Open accessAbstract
The concentration of luteinizing hormone (LH), pregnanediol-3-glucuronide (PGD), and estriol-16-Glucuronide (E3G) were measured in daily morning urine specimens from 53 infertile women. In 26 of 29 women with various degrees of proven endometriosis, two distinct midcycle peaks of LH were found 2 or 3 days apart. Patients with LH peaks separated by 3 days had significantly more severe endometriosis than those with a single peak. Maximum concentrations of E3G were found to be delayed until after the first LH peak in these patients, and PGD concentrations did not rise until the time of the second LH peak, making actual luteal function of shorter duration than normal. From the data on LH, it appears that an inappropriate hormonal feedback mechanism is operative in endometriosis.
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Women with endometriosis demonstrate reduced LH levels, indicating a lower frequency of GnRH and LH pulses.
“Women with endometriosis demonstrate reduced LH levels, indicating a lower frequency of GnRH and LH pulses (Cahill et al., 1995; Cheesman et al., 1982; Tummon et al., 1988).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Cheesman et al., 1982
Menstrual cycles of women with endometriosis more frequently demonstrate two LH surges compared with the typical single surge recorded in control subjects.
“Menstrual cycles of women with endometriosis more frequently demonstrate two LH surges compared with the typical single surge recorded in control subjects (90% of endometriosis cycles showed biphasic LH surges in Cheesman et al., 1982, and 17% in Vaughan Williams et al., 1986), which contrasts with the absence of an LH surge, and corresponding anovulation, found in PCOS.”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Cheesman et al., 1982
Cites
The Luteinized Unruptured Follicle Syndrome and Endometriosis
Dmowski, W. P., Rao, R., & Scommegna, A. (1980) · Fertility and Sterility · doi:10.1016/s0015-0282(16)44473-0 · Cited by 96 · see citing works
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Occult ovulatory dysfunction in women with minimal endometriosis or unexplained infertility
Tummon, I. S., Maclin, V. M., Radwanska, E., Binor, Z., & Dmowski, W. P. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60304-7 · Cited by 106 · see citing works
Menstrual characteristics associated with endometriosis
Arumugam, K., & Lim, J. M. H. (1997) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1997.tb14357.x · Cited by 94 · see citing works
Endometriosis and polycystic ovary syndrome are diametric disorders
Dinsdale, N. L., & Crespi, B. J. (2021) · Evolutionary Applications · doi:10.1111/eva.13244 · Cited by 90 · see citing works
“Women with endometriosis demonstrate reduced LH levels, indicating a lower frequency of GnRH and LH pulses (Cahill et al., 1995; Cheesman et al., 1982; Tummon et al., 1988).”
BackgroundResultPituitary—ovarian dysfunction as a cause for endometriosis-associated and unexplained infertility*
Cahill, D. J., Wardle, P. G., Maile, L. A., Harlow, C. R., & Hull, M. G. R. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a135876 · Cited by 53 · see citing works
The association of intrauterine filling defects on hysterosalpingogram with endometriosis
McBean, J. H., Gibson, M., & Brumsted, J. R. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58562-8 · Cited by 40 · see citing works
- Authors
- Cheesman, K. L., Ben-Nun, I., Chatterton, R. T., & Cohen, M. R.
- Affiliations
- Northwestern University (US)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1982-11
- Volume
- 38
- Issue
- 5
- Pages
- 542-548
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2410294255
- Cited by
- 54
- References
- 1
- Citations by year
- 2023: 2 · 2021: 2 · 2020: 1 · 2018: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- luteinizing hormone, pregnanediol-3-glucuronide, endometriosis, female infertility, luteal phase duration, luteal function, urinary steroid metabolites
- MeSH terms
- Adult, Endometriosis, Estriol, Female, Humans, Infertility, Female, Luteinizing Hormone, Luteal Phase, Menstruation, Pregnanediol, Radioimmunoassay
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