The association of intrauterine filling defects on hysterosalpingogram with endometriosis
Open accessAbstract
Objective To determine whether there is a significant association between the presence of polyps or polypoid endometrium on hysterosalpingogram (HSG) with the presence of pelvic or peritoneal endometriosis.Design Retrospective chart review.Setting Department of Reproductive Endocrinology and Infertility at the University of Vermont, College of Medicine.Patients One hundred twenty patients, all of whom had a HSG, hysteroscopy, and laparoscopy by a member of our department between 1989 and 1993.Main outcome measure Hysterosalpingograms were assessed for the presence of hypertrophic or polypoid endometrium. The presence of endometriosis was documented laparoscopically and scored according to The American Fertility Society classification and HSG findings were documented by hysteroscopy.Results Endometriosis was found in 27 of 32 women with polyps or polypoid endometrium but in only 19 of 88 women without. chi 2 analysis revealed a significant association between the demonstration of polyps or polypoid endometrium on HSG and the presence of endometriosis, chi 2(1) = 33.97. The predictive value of a positive test was 84% and the negative predictive value was 75%.Conclusion The presence of polyps or polypoid endometrium on HSG is significantly associated with the presence of pelvic or peritoneal endometriosis.
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While in healthy women the endometrial-myometrial lining is smooth and regular, it is irregular and sometimes polypoid in affected women.
“Moreover, while in healthy women the endometrial–myometrial lining is smooth and regular it is irregular and sometimes polypoid in affected women [3, 81].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [81]
Cites
Revised American Fertility Society Classification of Endometriosis: 1985
(1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48430-x · Cited by 1,803 · see citing works
Epidemiology of endometriosis-associated infertility.
Wheeler, J. M. (1989) · PubMed · Cited by 270 · see citing works
Brosens, I. A., Koninckx, P. R., & Corveleyn, P. A. (1978) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1978.tb10494.x · Cited by 191 · see citing works
Occult ovulatory dysfunction in women with minimal endometriosis or unexplained infertility
Tummon, I. S., Maclin, V. M., Radwanska, E., Binor, Z., & Dmowski, W. P. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60304-7 · Cited by 106 · see citing works
The Luteinized Unruptured Follicle Syndrome and Endometriosis
Dmowski, W. P., Rao, R., & Scommegna, A. (1980) · Fertility and Sterility · doi:10.1016/s0015-0282(16)44473-0 · Cited by 96 · see citing works
Endometriosis: Associations with Menorrhagia, Infertility and Oral Contraceptives
Sensky, T. E., & Liu, D. T. Y. (1980) · International Journal of Gynecology & Obstetrics · doi:10.1002/j.1879-3479.1980.tb00210.x · Cited by 90 · see citing works
Is, F., McCarron, G., Markham, R., Resta, T., & Watts, A. (1986) · PubMed · Cited by 82 · see citing works
Cheesman, K. L., Ben-Nun, I., Chatterton, R. T., & Cohen, M. R. (1982) · Fertility and Sterility · doi:10.1016/s0015-0282(16)46632-x · Cited by 54 · see citing works
Alterations in progesterone metabolism and luteal function in infertile women with endometriosis
Cheesman, K. L., Cheesman, S. D., Chatterton, R. T., & Cohen, M. R. (1983) · Fertility and Sterility · doi:10.1016/s0015-0282(16)47414-5 · Cited by 54 · see citing works
Premenstrual Spotting: Its Association with Endometriosis but Not Luteal Phase Inadequacy
Wentz, A. C. (1980) · Fertility and Sterility · doi:10.1016/s0015-0282(16)44772-2 · Cited by 31 · see citing works
Prostaglandin F2 synthesis and metabolism by luteal phase endometrium in vitro
Brumsted, J. R., Chapitis, J., Deaton, J. L., Riddick, D. H., & Gibson, M. (1989) · Fertility and Sterility · doi:10.1016/s0015-0282(16)61029-4 · Cited by 10 · see citing works
Self-citationHysterographic Evidence of Polypoid Filling Defects in the Uterine Cavity
Slezak, P., & Tillinger, K. ‐. (1975) · Radiology · doi:10.1148/115.1.79 · Cited by 8 · see citing works
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Cited by
Sorted by citations
The pathophysiology of endometriosis and adenomyosis, tissue injury and repair
Leyendecker, G., Wildt, L., & Mall, G. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1191-0 · Cited by 418 · see citing works
AAGL Practice Report: Practice Guidelines for the Diagnosis and Management of Endometrial Polyps
(2011) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2011.09.003 · Cited by 281 · see citing works
“There appears to be an association between the finding of endometrial polyps and other benign diseases including myomas, cervical polyps, and endometriosis [11,18–20].”
BackgroundBosteels, J. J. A., Weyers, S., Puttemans, P., Panayotidis, C., Herendael, B. V., Gomel, V., Mol, B. W., Mathieu, C., & D’Hooghe, T. M. (2009) · Human Reproduction Update · doi:10.1093/humupd/dmp033 · Cited by 254 · see citing works
“(McBean et al., 1996; Kim et al., 2003).”
Endometriosis: A dysfunction and disease of the archimetra
Leyendecker, G. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.752 · Cited by 199 · see citing works
“These range from gross morphological changes such as a polypoid appearance of the endometrium in hysterosalpingography (McBean et al., 1996) to microscopic changes in immunocytochemistry such as an aberrant integrin expression (Lessey et al.”
Smooth muscles are frequent components of endometriotic lesions
Anaf, V. (2000) · Human Reproduction · doi:10.1093/humrep/15.4.767 · Cited by 183 · see citing works
“These range from gross morphological changes such as the polypoid appearance of the endometrium at hysterosalpingography (McBean et al., 1996), to changes in immunocytochemistry such as aberrant integrin expression (Lessey et al., 1994), and biochemical changes such as overexpression of plasminogen…”
BackgroundMedical management of endometriosis and infertility
Lessey, B. A. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)00519-7 · Cited by 157 · see citing works
A new concept of endometriosis and adenomyosis, tissue injury and repair (TIAR)
Leyendecker, G., & Wildt, L. (2011) · hmbci · doi:10.1515/hmbci.2011.002 · Cited by 147 · see citing works
Is endometriosis an endometrial disease?
Vinatier, D., Cosson, M., & Dufour, P. (2000) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(99)00263-8 · Cited by 115 · see citing works
High Frequency of Endometrial Polyps in Endometriosis
Kim, M. R., Kim, Y. A., Jo, M. Y., Hwang, K. J., & Ryu, H. S. (2003) · The Journal of the American Association of Gynecologic Laparoscopists · doi:10.1016/s1074-3804(05)60233-2 · Cited by 88 · see citing works
High prevalence of endometrial polyps in endometriosis-associated infertility
Shen, L., Wang, Q., Huang, W., Wang, Q., Yuan, Q., Huang, Y., & Lei, H. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.04.067 · Cited by 50 · see citing works
Surgical Management of Endometrial Polyps in Infertile Women: A Comprehensive Review
Pereira, N., Petrini, A. C., Lekovich, J. P., Elias, R. T., & Spandorfer, S. D. (2015) · Surgery Research and Practice · doi:10.1155/2015/914390 · Cited by 36 · see citing works
“There also appears to be an association between endometrial polyps and other benign gynecologic conditions such as cervical polyps and endometriosis [21, 22].”
BackgroundRisk of endometrial polyps in women with endometriosis: a meta-analysis
Zheng, Q., Mao, H., Zhao, Y.-J., Zhao, J., Wei, X., & Liu, P. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0092-2 · Cited by 34 · see citing works
“McBean first reported the association of endometriosis and EP in 1996 [24].”
BackgroundLin, S., Xie, X., Guo, Y., Zhang, H., Liu, C., Yi, J., Su, Y., Deng, Q., & Zhu, W. (2020) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2020.09.020 · Cited by 28 · see citing works
Ovarian endometriosis associated with ovarian cancer and endometrial–endocervical polyps
Kontoravdis, A., Augoulea, A., Lambrinoudaki, I. V., Christodoulakos, G., Tzortziotis, D., Grammatikakis, I., Kontoravdis, N., & Creatsas, G. C. (2007) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2007.00527.x · Cited by 21 · see citing works
“reported the presence of endometriosis at laparoscopy in 27 of 32 women in whom hysterosalpingography suggested the presence of endometrial polyps.(27) Although the absence of a control group in the present study does not allow for the establishment of a definite association between endometriosis and endometrial polyp…”
BackgroundEndometrial polyps and subfertility
Alansari, L. M., & Wardle, P. G. (2012) · Human Fertility · doi:10.3109/14647273.2012.711499 · Cited by 20 · see citing works
“The first study, by McBean et al. (1996), involved a retrospective chart review of 120 patients, all of whom had a hysterosalpingogram (HSG), hysteroscopy and laparoscopy.”
BackgroundBosteels, J., Weyers, S., Mathieu, C., Mol, B. W., & D’Hooghe, T. (2010) · Europe PMC (PubMed Central) · Cited by 16 · see citing works
Demographic and Clinical Features of Endometrial Polyps in Patients with Endometriosis
Wang, N., Zhang, Y., & Liu, B. (2016) · BioMed Research International · doi:10.1155/2016/1460793 · Cited by 15 · see citing works
Bennett, M. W., Dick, E. J., Schlabritz‐Loutsevitch, N., López-Alvarenga, J. C., Williams, P. C., Sharp, R. M., & Hubbard, G. B. (2009) · Journal of Medical Primatology · doi:10.1111/j.1600-0684.2009.00350.x · Cited by 15 · see citing works
Whitehill, K., Yong, P. J., & Williams, C. (2012) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)35271-9 · Cited by 14 · see citing works
Sessile polyps and pedunculated polyps respond differently to oral contraceptives
Wada‐Hiraike, O., Osuga, Y., Hiroi, H., Fujimoto, A., Maruyama, M., Yano, T., & Taketani, Y. (2010) · Gynecological Endocrinology · doi:10.3109/09513590.2010.492884 · Cited by 14 · see citing works
“59%) patients without polyps or polypoids [14].”
Independent risk factors for endometrial polyps: diabetes, hypertension, and obesity
Hassa, H., Korkmazer, E., Tokgöz, V. Y., & Öge, T. (2012) · Asian Pacific Journal of Reproduction · doi:10.1016/s2305-0500(13)60099-8 · Cited by 8 · see citing works
LEYENDECKER, G., Kunz, G., Noe, M., Herbertz, M., Beil, D., Huppert, P. E., & Mall, G. (1999) · Reproduktionsmedizin · doi:10.1007/s004440050126 · Cited by 8 · see citing works
“Mittels Hysterosalpingographie konnte gezeigt werden, daû mit der Hyper- und Dysperistaltik eine Störung des Spermientransports verbunden ist, indem bereits während der mittleren Proliferationsphase keine Ausrichtung des Transports zur ¹dominantenª, sondern zur kontralateralen Tube erfolgte und präovulatorisch der Tra…”
BackgroundInfluentialEndometriosis-associated infertility
Haney, A. F. (1997) · Reproductive Medicine Review · doi:10.1017/s0962279900001496 · Cited by 8 · see citing works
Association between endometriosis and endometrial polyps: a systematic review and meta-analysis
Fiore, A. D., Casalechi, M., Somigliana, E., Viganò, P., & Salmeri, N. (2025) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2025.105106 · Cited by 5 · see citing works
Uterine Peristalsis and the Development of Endometriosis and Adenomyosis
LEYENDECKER, G., & Wildt, L. (2011) · Wiley eBooks · doi:10.1002/9781444398519.ch20 · Cited by 4 · see citing works
Fattah, E. A. A. E. (2017) · Obstetrics and Gynecology International · doi:10.1155/2017/5869028 · Cited by 3 · see citing works
Endometriosis and adenomyosis – a shared pathophysiology
LEYENDECKER, G., Wildt, L., & Mall, G. (2010) · CNR Solar (Scientific Open-access Literature Archive and Repository) (Consiglio Nazionale delle Ricerche) · Cited by 2 · see citing works
LEYENDECKER, G., & Wildt, L. (2011) · Springer eBooks · doi:10.1007/978-3-642-15012-8_9 · Cited by 2 · see citing works
Clinical Aspects of Endometriosis
Bokor, A., Meuleman, C., & D’Hooghe, T. M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1436-1_13 · Cited by 2 · see citing works
Lieng, M. (2014) · Springer eBooks · doi:10.1007/978-3-662-44059-9_6 · Cited by 1 · see citing works
Semi-invasive Diagnosis of Endometriosis Doctoral Thesis
Bokor, A. (2010) · Cited by 1 · see citing works
Atypical Endometriosis: Its Presentation and Management
Blackwell, R. E. (1998) · Springer eBooks · doi:10.1007/978-1-4612-1752-7_6 · Cited by 1 · see citing works
Studies on the effectiveness of endoscopic surgery in reproductive medicine
Bosteels, J. (2014) · Lirias · Cited by 1 · see citing works
Katz, V. L. (2007) · Elsevier eBooks · doi:10.1016/b978-0-323-02951-3.50014-5 · Cited by 1 · see citing works
Contribution to the physiopathology, symptomatology and treatment of deep infiltrating endometriosis
Anaf, V., Noël, J. C., & Rodesch, F. (2004) · Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles)
Multicentric Study on Endometrial Polyps and Endometriosis: Are They True or False Friends?
Giambanco, L., Iannone, V., Borriello, M., Sozzi, G., Scibilia, G., Chiàntera, V., & Scollo, P. (2020) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2020.1070081
“But is this link effective to justify and find out higher EP prevalence among endometriosis patients and inversely? Many Authors reported a strong association between E and EP [1] [4] [6] [11] [12] [13].”
BackgroundLeone, F. P. G. (2016) · Springer eBooks · doi:10.1007/978-3-319-41037-1_4
Rare Case Report of Robert Uterus with Ovarian Endometrioma
Khan, T. F. (2023) · International Journal of Clinical Case Reports and Reviews · doi:10.31579/2690-4861/323
Cui, L., Yang, J., Zhang, Y., Wang, Y., Xie, W., & Xue, X. (2026) · Medicine · doi:10.1097/md.0000000000047841
“In 1996, McBean [3] first reported the correlation between the 2 diseases.”
Bandini, V., Salmeri, N., Preda, A., Bracci, B., Cosentino, E., Vignali, M., & Vercellini, P. (2026) · Gynecologic and Obstetric Investigation · doi:10.1159/000552113
“Infertile patients are routinely subjected to high-resolution ultrasonographic assessments of the uterine cavity, which may increase the detection of minor endometrial irregularities (i.e., “polypoid endometrium”), sometimes risking overestimation of true polyp prevalence [5].”
- Authors
- McBean, J. H., Gibson, M., & Brumsted, J. R.
- Affiliations
- University of Vermont (US)
- ORCID
- Gibson, Mark
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1996-10
- Volume
- 66
- Issue
- 4
- Pages
- 522-526
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W92907971
- Cited by
- 40
- References
- 12
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2020: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2012: 3
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometriosis, endometrial polyps, hysterosalpingography, pelvic endometriosis, peritoneal endometriosis, predictive value
- MeSH terms
- Adult, Endometriosis, Female, Humans, Hysterosalpingography, Infertility, Female, Polyps, Retrospective Studies, Endometrial Neoplasms
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