Luteinizing hormone receptor disorder in endometriosis
Open accessAbstract
Luteinizing hormone (LH) receptor concentrations in ovarian follicles and corpora lutea were measured in 51 patients with histologically proven endometriosis and in 41 control patients. The LH receptor concentrations in cases of endometriosis were lower during the early (0.43 +/- 0.11 [mean +/- standard error] versus 1.31 +/- 0.27 fmol/mg protein; P less than 0.001) and late (0.48 +/- 0.10 versus 1.59 +/- 0.22 fmol/mg protein; P less than 0.001) follicular phase, and during the late luteal phase (2.62 +/- 0.55 versus 4.62 +/- 0.65 fmol/mg protein; P less than 0.05) of the cycle than in control patients. In contrast to the control patients, the LH receptor concentration during the follicular phase remained constant in endometriosis, being lower in patients with extensive or severe disease than in patients with moderate or mild disease (0.28 +/- 0.07 versus 0.61 +/- 0.21 fmol/mg protein; P less than 0.05). Endometriosis-associated infertility might be a consequence of a defect in the mechanism mediating LH action in the ovaries.
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Women with endometriosis demonstrate lower concentrations of LH receptors in the ovarian follicles throughout the menstrual cycle.
“Women with endometriosis demonstrate lower concentrations of LH receptors in the ovarian follicles throughout the menstrual cycle (Kauppila et al., 1982; Rönnberg et al., 1984) and their cycles involve longer follicular phases marked by delayed surges of LH (Cahill et al., 1995).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Rönnberg et al., 1984
Cites
Endometriosis and anovulation: a coexisting problem in the infertile female
Soules, M. R., Malinak, L. R., Bury, R., & Poindexter, A. (1976) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(76)90578-0 · Cited by 81 · see citing works
Low LH (Hcg) Receptor Concentration in Ovarian Follicles in Endometriosis
Kauppila, A., Rajaniemi, H., & Rönnberg, L. (1982) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.3109/00016348209156957 · Cited by 14 · see citing works
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Occult ovulatory dysfunction in women with minimal endometriosis or unexplained infertility
Tummon, I. S., Maclin, V. M., Radwanska, E., Binor, Z., & Dmowski, W. P. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60304-7 · Cited by 106 · see citing works
Endometriosis and polycystic ovary syndrome are diametric disorders
Dinsdale, N. L., & Crespi, B. J. (2021) · Evolutionary Applications · doi:10.1111/eva.13244 · Cited by 90 · see citing works
“…endometriosis: Women with endometriosis demonstrate lower concentrations of LH receptors in the ovarian follicles throughout the menstrual cycle (Kauppila et al., 1982; Rönnberg et al., 1984) and their cycles involve longer follicular phases marked by delayed surges of LH (Cahill et al., 1995).”
Background
- Authors
- Rönnberg, L., Kauppila, A., & Rajaniemi, H.
- Affiliations
- University of Oulu (FI)
- ORCID
- Rajaniemi, Hannu
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1984-07
- Volume
- 42
- Issue
- 1
- Pages
- 64-68
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2419326061
- Cited by
- 53
- References
- 2
- Citations by year
- 2024: 1 · 2023: 3 · 2021: 2 · 2020: 1 · 2017: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- endometriosis, luteinizing hormone receptor, ovarian follicles, corpus luteum, follicular phase, luteal phase, endometriosis-associated infertility, ovarian steroidogenesis
- MeSH terms
- Adult, Corpus Luteum, Endometriosis, Female, Ovarian Follicle, Humans, Menstruation, Middle Aged, Ovarian Neoplasms, Receptors, Cell Surface, Receptors, LH
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