Low LH (Hcg) Receptor Concentration in Ovarian Follicles in Endometriosis
Abstract
The concentration of LH (hCG) receptors in the granulosa cells of ovarian follicles was assayed in 20 patients with histologically proven endometriosis and in 6 control patients. The levels of receptors in 15 patients with ovarian endometriosis (0.48 +/- 0.46 fmol/mg protein) and in 5 patients with endometriosis without ovarian involvement (0.51 +/- 0.52 fmol/mg protein) were lower (p less than 0.01 and p less than 0.05, respectively) than in control patients (1.32 less than 0.61 fmol/mg protein). The severity of the disease was not reflected in the results. The low receptor concentration in endometriosis suggests a failure in the mechanism mediating LH action in the follicle.
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Women with endometriosis demonstrate lower concentrations of LH receptors in the ovarian follicles throughout the menstrual cycle.
“Women with endometriosis demonstrate lower concentrations of LH receptors in the ovarian follicles throughout the menstrual cycle (Kauppila et al., 1982; Rönnberg et al., 1984) and their cycles involve longer follicular phases marked by delayed surges of LH (Cahill et al., 1995).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Kauppila et al., 1982
Cites
The Luteinized Unruptured Follicle Syndrome and Endometriosis
Dmowski, W. P., Rao, R., & Scommegna, A. (1980) · Fertility and Sterility · doi:10.1016/s0015-0282(16)44473-0 · Cited by 96 · see citing works
Endometriosis and anovulation: a coexisting problem in the infertile female
Soules, M. R., Malinak, L. R., Bury, R., & Poindexter, A. (1976) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(76)90578-0 · Cited by 81 · see citing works
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Carlberg, M., Nejaty, J., Fröysa, B., Guan, Y.-M., Söder, O., & Bergqvist, A. (2000) · Human Reproduction · doi:10.1093/humrep/15.6.1250 · Cited by 132 · see citing works
Endometriosis and polycystic ovary syndrome are diametric disorders
Dinsdale, N. L., & Crespi, B. J. (2021) · Evolutionary Applications · doi:10.1111/eva.13244 · Cited by 90 · see citing works
“…endometriosis: Women with endometriosis demonstrate lower concentrations of LH receptors in the ovarian follicles throughout the menstrual cycle (Kauppila et al., 1982; Rönnberg et al., 1984) and their cycles involve longer follicular phases marked by delayed surges of LH (Cahill et al., 1995).”
BackgroundPathophysiology of Endometriosis-Associated Infertility
Burns, W. N., & Schenken, R. S. (1999) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-199909000-00014 · Cited by 61 · see citing works
Luteinizing hormone receptor disorder in endometriosis
Rönnberg, L., Kauppila, A., & Rajaniemi, H. (1984) · Fertility and Sterility · doi:10.1016/s0015-0282(16)47959-8 · Cited by 53 · see citing works
Self-citationSequential clomiphene citrate-menotropin therapy for induction or enhancement of ovulation
Kemmann, E., & Jones, J. R. (1983) · Fertility and Sterility · doi:10.1016/s0015-0282(16)47116-5 · Cited by 31 · see citing works
Abae, M., Glassberg, M., Majercik, M., Yoshida, H., Vestal, R., & Puett, D. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56760-0 · Cited by 26 · see citing works
Bergqvist, A. (2002) · Human Reproduction Update · doi:10.1093/humupd/8.1.79 · Cited by 30 · see citing works
Geng, T., Sun, Y.-F., Cheng, L., Cao, Y.-M., Zhang, M., Hong, Z.-D., Ma, L., & Zhang, Y.-Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.853563 · Cited by 12
“Although previous studies have claimed that inhibitors (36) and environmental endocrine disruptors (37) may play an important role in impaired ovulation, dysfunctional gene expression in patients with endometriosis draws focus on the expression of LHCGR (16).”
BackgroundA case of spontaneous abortion related to ovarian endometriosis in a Golden Retriever dog.
Demirel, M. (2017) · Iranian Journal of Veterinary Research · doi:10.22099/ijvr.2017.4033 · Cited by 3
“…of Veterinary Research, Shiraz University IJVR, 2017, Vol. 18, No. 1, Ser. No. 58, Pages 63-66 65 that luteinizing hormone receptor concentrations in ovarian follicles and corpora lutea in cases of ovarian endometriosis are lower than in healthy women (Kauppila et al., 1982; Rönnberg et al., 1984).”
BackgroundMedikamentöse und konservative Therapie
Finas, D., Küpker, W., Diedrich, K., & Felberbaum, R. E. (2004) · Springer eBooks · doi:10.1007/978-3-7091-0574-0_6 · Cited by 2 · see citing works
Rezidivierende Endometriose—ein Kofaktor der vorzeitigen Menopause?
Finas, D., Schultze-Mosgau, A., Griesinger, G., Hornung, D., Küpker, W., Felberbaum, R., & Diedrich, K. (2003) · Gynäkologische Endokrinologie · doi:10.1007/s10304-003-0032-7
“Diese könnte möglicherweise auf einen erniedrigten Luteinisierendes-Hormon- (LH-) Rezeptor-Besatz in den Follikeln und in den Corpora lutea zurückzuführen sein [31].”
BackgroundDecreased concentration of ovarian LH(hCG) receptor in polycystic ovarian disease and endometriosis
Kauppila, A., Rajaniemi, H., & Rönnberg, L. (1984) · doi:10.1007/978-94-011-7621-7_19
Self-citation
- Authors
- Kauppila, A., Rajaniemi, H., & Rönnberg, L.
- Affiliations
- University of Oulu (FI)
- Corresponding author
- Kauppila, Antti
- ORCID
- Rajaniemi, Hannu
- Venue
- Acta Obstetricia et Gynecologica Scandinavica
- Publisher
- Wiley
- Published
- 1982-01
- Volume
- 61
- Issue
- 1
- Pages
- 81-83
- ISSN
- 0001-6349 (ISSN-L)
- 1600-0412
- OpenAlex
- W1984668030
- Cited by
- 14
- References
- 0
- Citations by year
- 2022: 1 · 2021: 1 · 2017: 1
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Obstetricia Et Gynecologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- endometriosis, luteinizing hormone receptor, human chorionic gonadotropin receptor, ovarian follicles, granulosa cells, endometrioma, receptor concentration
- MeSH terms
- Adult, Endometriosis, Female, Chorionic Gonadotropin, Ovarian Follicle, Humans, Luteinizing Hormone, Middle Aged, Receptors, Cell Surface, Receptors, LH
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