Cited by 249Estrogen and related hormone effectsOvarian function and disordersReproductive Biology and Fertility

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Clomiphene citrate: mechanism(s) and site(s) of action—a hypothesis revisited

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Wallach, Edward E., Adashi, Eli Y.·1984·Fertility and Sterility

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Abstract

It has now been 28 years since the synthesis of clomiphene citrate (CC) by Dr. Frank P. Palopoli,l, 2 then a synthetic chemist with the William S. Merrell Company.However, despite intense basic and clinical research and a cumulative bibliography now approaching 8000 contributions, the mechanism(s) and site(s) of action of CC have only been partially clarified.This knowledge gap is particularly striking in view of the widespread and highly successful use of CC worldwide.Indeed, the clinical utility of CC has recently been further enhanced through its introduction as a primary agent in the management of luteal phase dysfunction 3 and its application in the area of in vitro fertilization. 4It is the intent of this presentation to critically explore the current hypothesis underlying the mechanism(s) and site(s) of action of CC and to propose its expansion and modification in keeping with recently accumulated experimental data.

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Authors: Wallach, E. E., & Adashi, E. Y.
Affiliations: University of Maryland, Baltimore (US)
ORCID: Adashi, Eli Y.
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 1984-09
Volume: 42
Issue: 3
Pages: 331-344
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/s0015-0282(16)48069-6
OpenAlex: W138858130
Cited by: 249
References: 85
Citations by year: 2026: 4 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 5
FWCI: 4.86
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 13782 d)
Locations: Fertility and Sterility (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: clomiphene citrate, mechanism of action, site of action, in vitro fertilization, ovulation induction
MeSH terms: Animals, Aromatase, Binding Sites, Clomiphene, Estrogen Antagonists, Estrogens, Female, Follicle Stimulating Hormone, Ovarian Follicle, Humans, Hypothalamus, Luteinizing Hormone, Neurosecretory Systems, Ovary, Ovulation, Pituitary Gland, Progesterone, Receptors, Estrogen, Structure-Activity Relationship, Rats, In Vitro Techniques

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Clomiphene citrate: mechanism(s) and site(s) of action—a hypothesis revisited

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