The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Dexamethasone suppresses sex-hormone binding globulin
Open accessAbstract
Dexamethasone suppression (DEX-S) for 14 days has been used to determine the probable source of androgen excess. The exact mechanism(s) of DEX-S is still unclear. The authors postulated that dexamethasone (DEX) inhibits either the synthesis or secretion of sex-hormone binding globulin (SHBG). To examine this hypothesis, 14 women with polycystic ovarian disease (PCOD) and 3 volunteers were given DEX for 14 days. The PCOD group included obese and nonobese women (+/- 15% ideal body weight). Plasma determinations by radioimmunoassay of total testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate, luteinizing hormone; follicle-stimulating hormone; cortisol, and SHBG were made. DEX suppressed SHBG levels (P less than 0.01). SHBG levels were significantly lower in the obese than in the nonobese (P less than 0.01). All androgens were suppressed by DEX, with the exception of androstenedione post-DEX levels, which were significantly greater than pre-DEX levels in 6 of 14 subjects (P greater than 0.05). This observation is consistent with DEX suppression of SHBG.
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“In another example, treatment with synthetic glucocorticoids, for instance dexamethasone, has also led to decreased SHBG levels in women with PCOS and in children with acute lymphoblastic leukemia [112, 113].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [112]
Citations
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Cited by
Narinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96
Metadata
- Authors
- Blake, R. E., Rajguru, S., Nolan, G. H., & Ahluwalia, B. S.
- Affiliations
- Howard University (US)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1988-01
- Volume
- 49
- Issue
- 1
- Pages
- 66-70
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1442958979
- Cited by
- 24
- References
- 21
- Citations by year
- 2025: 2 · 2022: 1 · 2018: 1 · 2015: 1 · 2012: 2
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 12565 d)
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (IS0RR08244-01)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- dexamethasone suppression test, sex hormone-binding globulin, polycystic ovary syndrome, hyperandrogenism, obesity, free testosterone, androstenedione, luteinizing hormone, follicle-stimulating hormone, cortisol, androgen production
- MeSH terms
- Adult, Androgens, Dexamethasone, Female, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Obesity, Polycystic Ovary Syndrome, Reference Values, Sex Hormone-Binding Globulin
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