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Cited by 1,127Hormonal and reproductive studiesEstrogen and related hormone effectsSexual Differentiation and Disorders

The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.

Sex‐hormone binding-globulin

ANDERSON, DAVID C.·1974·Clinical Endocrinology
DOI 10.1111/j.1365-2265.1974.tb03298.x
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Abstract

A review was made to understand how plasma binding protein might influence sex-hormone action in target tissues. Steroids are predominately bound to plasma proteins and only unbound steroids enter the cells. Sex-hormone-binding globulin (SHBG) binds to both the main circulating steroid T and E2 but changes in SHBG concentrations exert significant results. Increased SHBG levels increase estrogen production and decreases T activity; whereas, increased androgens increase T action and inhibit SHBG production. These disturbances in hormone maintenance may lead to abnormal adult sex differentiation such as hirsutism and forms of hynaecomastia. By developing SHBG concentration measurement methods-responses of hirsutism to glucocorticoid or estrogem may be assessed. In addition, the effect of thyroid hormones on SHBG may also have therapeutic implications in endocrine disease.

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Crossref · 10.1111/j.1365-2265.1974.tb03298.x

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Research works printed but not linked: 15

  1. Anderson D.C.(1973)Studies on plasma androgens and sex‐hormone‐binding globulin in health and disease.Thesis for Doctorate in Medicine submitted toUniversity of Dundee.
  2. Baulieu E.‐E., 1971, Androgen receptors in rat ventral prostrate. In: Schering Workshop on Steroid Hormone “Receptors”, Berlin, Dec. 7–9, 1970, Advances in the Biosciences, 7, 179
  3. Crépy O., 1967, Rôle des hormones thyroidennes dans les interactions entre la testosterone et les proteines seriques, Comptes Rendus de l'Academie des Sciences, 264, 2651
  4. Daughaday W.H., 1956, Evidence for two corticosteroid‐binding systems in human plasma, Journal of Laboratory and Clinical Medicine, 48, 799
  5. DeMoor P. Heyns W.&Bouillon R.(1971)An acute fall in SHBG activity related to an increase in plasma growth hormone levels.First International Symposium of the Journal of Steroid Biochemistry Abstract 29.
  6. Dray F., 1969, Anomalies de l'affinité de liason de la testostérone dans le serum des sujets thyrotoxicosiques et dans le virilism pilaire idiopathique, Annales d'Endocrinologie, 30
  7. James F., 1970, Interaction of sex hormones with target tissues, Advances in Steroid Biochemistry, 2, 315
  8. Jensen E.V., 1962, Basic guides to the mechanism of oestrogen action, Recent Progress in Hormone Research, 18, 387
  9. Korenman S.G., 1968, In: Discussion, Recent Progress in Hormone Research, 24, 73
  10. Mauvais‐Jarvis P., 1967, Études in vivo sur les variations d'activité de la 5α‐δ4‐3‐oxostéroide oxydo‐réductase proroquées par l'hormone thyroidienne et les oestrogènes de synthèse, Comptes Rendus de l'Académie des Sciences, 264, 2825
  11. Mercier C., 1966, A testosterone binding globulin. In: Proceedings of the Second Symposium on Steroid Hormones, Ghent, 1965, Excerpta Medica International Congress Series, 101, 212
  12. Murphy B.E.P., 1971, Androgen fractionation in normal, pregnant and hirsute women
  13. Seal U.S., 1965, Purification, some properties and composition of the corticosteroid‐ and thyroxine‐binding globulins from human serum. Proceedings of the Second International Congress of Endocrinology, Excerpta Medica International Congress Series, 83, 325
  14. Weinheimer B., 1966, Plasma steroid concentrations of adrenal venous blood from women with and without hirsutism. In: Androgens in normal and pathological conditions, Excerpta Medica International Congress Series, 101, 36
  15. Westphal U., 1971, Characteristics of steroid‐protein interactions, including results on a progesterone‐binding globulin. Proceedings of the Third International Congress of Hormonal Steroids, Excerpta Medica International Congress Series, 219, 410

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Metadata

Authors
ANDERSON, D. C.
Affiliations
St Bartholomew's Hospital (GB)
Corresponding author
ANDERSON, DAVID C.
Venue
Clinical Endocrinology
Publisher
Wiley
Published
1974-01
Volume
3
Issue
1
Pages
69-96
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.1974.tb03298.x
OpenAlex
W2054877457
Cited by
1,127
References
133
Citations by year
2026: 9 · 2025: 6 · 2024: 10 · 2023: 11 · 2022: 13 · 2021: 12 · 2020: 9 · 2019: 12 · 2018: 14 · 2017: 14 · 2016: 16 · 2015: 18 · 2014: 16 · 2013: 20 · 2012: 23
FWCI
3.93
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 12494 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords
sex hormone-binding globulin, steroid binding proteins, testosterone, estradiol, androgens, hirsutism, glucocorticoid response, estrogen response, thyroid hormones, endocrine disorders
MeSH terms
Adolescent, Beta-Globulins, Carrier Proteins, Estradiol, Estrogens, Ethinyl Estradiol, Female, Glucocorticoids, Glycoproteins, Gynecomastia, Hirsutism, Humans, Hyperthyroidism, Hypogonadism, Luteinizing Hormone, Liver, Liver Cirrhosis, Male, Medroxyprogesterone, Molecular Weight, Myxedema, Ovarian Cysts, Pregnancy, Protein Binding, Puberty, Serum Globulins, Sex Factors, Gonadal Steroid Hormones, Androgen-Insensitivity Syndrome, Testosterone, Thyroxine

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