The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Fertilization and pregnancy after assisted oocyte activation and intracytoplasmic sperm injection in a case of round-headed sperm associated with deficient oocyte activation capacity
Open accessAbstract
Objective To investigate a method of assisted activation of human oocytes for the treatment of infertility resulting from globozoospermia associated with deficient oocyte activation capacity. Design The mouse oocyte activation test was used to analyze the oocyte activation capacity of the sperm cells of a patient with globozoospermia. Fresh donor human oocytes were used for determining the most appropriate procedure for oocyte activation. Setting Infertility Center, University Hospital of Ghent. Patient(s) A couple with infertility resulting from globozoospermia. Intervention(s) Intracytoplasmic sperm injection, assisted oocyte activation, and embryo transfer. Main outcome measure(s) Oocyte activation and fertilization rates, implantation, and pregnancy. Result(s) Deficiency in oocyte activation capacity was found in the sperm of a patient with globozoospermia. This deficiency was proven by the mouse oocyte activation test and was confirmed further by lack of activation of human oocytes after simple sperm injection. Only human oocytes that were injected with sperm and subjected to calcium chloride and ionophore treatment underwent activation. Transfer of embryos obtained by this procedure of assisted oocyte activation resulted in an ongoing pregnancy. Conclusion(s) Assisted oocyte activation of human oocytes is useful when globozoospermia is associated with absence of oocyte activation capacity in the sperm. These cases can be identified by the mouse oocyte activation test.
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“Globozoospermic men were infertile and some were able to achieve a pregnancy after ICSI.”
From Recommendations for Human Sperm Morphology Assessment in 2025: An Expert Review From the French BLEFCO Group (2026) · cites this paper as [32]
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“Success rates of ICSI remain rather low, with many failures or with lower fertilisation rates [30, 31, 32, 33].”
From Recommendations for Human Sperm Morphology Assessment in 2025: An Expert Review From the French BLEFCO Group (2026) · cites this paper as [32]
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Metadata
- Authors
- Rybouchkin, A. V., Van der Straeten, F., Quatacker, J., De Sutter, P., & Dhont, M.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 68
- Issue
- 6
- Pages
- 1144-1147
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2057657772
- Cited by
- 169
- References
- 6
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 7 · 2017: 3 · 2016: 4 · 2015: 12 · 2014: 8 · 2013: 10 · 2012: 13
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- globozoospermia, oocyte activation, assisted oocyte activation, intracytoplasmic sperm injection, male infertility, fertilisation (biology), pregnancy, calcium chloride, ionophores
- MeSH terms
- Calcimycin, Adult, Animals, Cytoplasm, Female, Fertilization in Vitro, Humans, Infertility, Male, Ionophores, Male, Microinjections, Oocytes, Pregnancy, Spermatozoa, Oocyte Donation, Mice
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