Andrology: Successful fertilization and establishment of pregnancies after intracytoplasmic sperm injection in patients with globozoospermia
Abstract
Globozoospermia or round-headed spermatozoa is a rare type of teratozoospermia where the acrosome is absent resulting in male infertility with no known therapy. A few studies have shown that round-headed spermatozoa cannot bind to or penetrate the zona pellucida, and no normal fertilization has been observed in in-vitro fertilization (IVF) after insemination of human oocytes with round-headed spermatozoa. In this study, the fertilization capacity of round-headed spermatozoa after intracytoplasmic sperm injection (ICSI) into human oocytes has been examined. In pre-clinical experiments, 45 oocytes were injected; 41 oocytes were intact after injection, 15 oocytes were fertilized normally, and 13 of these 15 oocytes developed further in vitro. ICSI was carried out in 11 treatment cycles of seven infertile couples with globozoospermia. Normal fertilization and embryo transfer occurred in four cycles (three patients). Positive serum human chorionic gonadotrophin was observed in three cycles (two patients); one patient had a pre-clinical abortion and the other patient became pregnant twice; the first pregnancy was ectopic and the second pregnancy is a twin pregnancy which is currently at 16 weeks of gestation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Globozoospermic men are infertile and some are able to achieve a pregnancy after ICSI.
“Globozoospermic men were infertile and some were able to achieve a pregnancy after ICSI.”
From Recommendations for Human Sperm Morphology Assessment in 2025: An Expert Review From the French BLEFCO Group (2026) · cites this paper as [30]
ICSI success rates in globozoospermia remain rather low, with many failures or lower fertilisation rates.
“Success rates of ICSI remain rather low, with many failures or with lower fertilisation rates [30, 31, 32, 33].”
From Recommendations for Human Sperm Morphology Assessment in 2025: An Expert Review From the French BLEFCO Group (2026) · cites this paper as [30]
Cites
Still being checked.
Cited by
Sorted by citations
The biology of infertility: research advances and clinical challenges
Matzuk, M. M., & Lamb, D. J. (2008) · Nature Medicine · doi:10.1038/nm.f.1895 · Cited by 948 · see citing works
Real‐Time Fine Morphology of Motile Human Sperm Cells is Associated With IVF‐ICSI Outcome
BARTOOV, B., Berkovitz, A., Eltes, F., Kogosowski, A., Menezo, Y. J. R., & Barak, Y. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02595.x · Cited by 425 · see citing works
Chemes, H. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg034 · Cited by 291 · see citing works
Dam, A. H. D. M., Feenstra, I., Westphal, J. R., Ramos, L., van Golde, R. J. T., & Kremer, J. A. M. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml047 · Cited by 270 · see citing works
Oocyte activation, phospholipase C zeta and human infertility
Kashir, J., Heindryckx, B., Jones, C., Sutter, P. D., Parrington, J., & Coward, K. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq018 · Cited by 267 · see citing works
Intracytoplasmic sperm injection
Steirteghem, A. V., Nagy, Z. P., Liu, J., Joris, H., Verheyen, G., Smitz, J. E. J., Tournaye, H. J., Liebaers, I., & Devroey, P. (1994) · Baillière s Clinical Obstetrics and Gynaecology · doi:10.1016/s0950-3552(05)80025-2 · Cited by 241 · see citing works
Self-citationHarbuz, R., Zouari, R., Pierre, V., Khelifa, M. B., Kharouf, M., Coutton, C., Merdassi, G., Abada, F., Escoffier, J., Nikas, Y., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.02.007 · Cited by 198 · see citing works
Schlegel, P. N. (1997) · Urology · doi:10.1016/s0090-4295(96)00379-2 · Cited by 188 · see citing works
Rybouchkin, A. V., Van der Straeten, F., Quatacker, J., De Sutter, P., & Dhont, M. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00378-6 · Cited by 169 · see citing works
Assisted oocyte activation following ICSI fertilization failure
Meerschaut, F. V., Nikiforaki, D., Heindryckx, B., & Sutter, P. D. (2014) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2014.01.008 · Cited by 161 · see citing works
Sperm chromosomal abnormalities are linked to sperm morphologic deformities
Lewis‐Jones, I., Aziz, N., Seshadri, S., Douglas, A., & Howard, P. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04411-4 · Cited by 160 · see citing works
Taylor, S. L., Yoon, S., Morshedi, M., Dowling-Lacey, D., Jellerette, T., Fissore, R. A., & Oehninger, S. (2009) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2009.12.024 · Cited by 144 · see citing works
Failure of oocyte activation after intracytoplasmic sperm injection using round-headed sperm
Battaglia, D. E., Koehler, J. K., Klein, N. A., & Tucker, M. J. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81486-0 · Cited by 138 · see citing works
Tesařík, J., Rienzi, L. F., Ubaldi, F., Mendoza, C., & Greco, E. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03291-0 · Cited by 135 · see citing works
ICSI: Where We Have Been and Where We Are Going
Palermo, G. D., Neri, Q. V., Takeuchi, T., & Rosenwaks, Z. (2009) · Seminars in Reproductive Medicine · doi:10.1055/s-0029-1202309 · Cited by 128 · see citing works
Montag, M. H. M., Köster, M., van der Ven, K., Bohlen, U., & van der Ven, H. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.02.002 · Cited by 104 · see citing works
Carrell, D. T., Emery, B. R., & Liu, L. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00498-1 · Cited by 102 · see citing works
Ebner, T., Montag, M. H. M., Montag, M., van der Ven, H., Ven, H. V. D., Ebner, T., Shebl, O. J., Oppelt, P., Hirchenhain, J., Krüssel, J.-S., et al. (2014) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2014.11.012 · Cited by 98 · see citing works
Eldar‐Geva, T., Brooks, B., Margalioth, E. J., Zylber-Haran, E., Gal, M., & Silber, S. J. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00369-8 · Cited by 97 · see citing works
Escoffier, J., Yassine, S., Lee, H. C., Martinez, G., Delaroche, J., Coutton, C., Karaouzène, T., Zouari, R., Metzler‐Guillemain, C., Pernet‐Gallay, K., et al. (2014) · Molecular Human Reproduction · doi:10.1093/molehr/gau098 · Cited by 97 · see citing works
Nagy, Z. P., Verheyen, G., Tournaye, H. J., & Steirteghem, A. C. V. (1998) · Human Reproduction · doi:10.1093/humrep/13.suppl_1.143 · Cited by 97 · see citing works
Self-citationGlobozoospermia is associated with chromatin structure abnormalities: Case report
Vicari, E. S. D. (2002) · Human Reproduction · doi:10.1093/humrep/17.8.2128 · Cited by 95 · see citing works
Kim, S. T., Beom, Y., Park, J. M., & Gye, M. C. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01698-8 · Cited by 92 · see citing works
Neri, Q. V., Rosenwaks, Z., & Palermo, G. D. (2015) · Seminars in Reproductive Medicine · doi:10.1055/s-0035-1546825 · Cited by 86 · see citing works
Tejera, A., Mollá, M., Muriel, L., Remohi, J. A., Pellicer, A., & de Pablo, J. L. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.11.056 · Cited by 84 · see citing works
Evaluation and treatment of familial globozoospermia in five brothers
Kilani, Z., Ismail, R., Ghunaim, S., Mohamed, H., Hughes, D. C., Brewis, I. A., & Barratt, C. L. R. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.03.064 · Cited by 83 · see citing works
Sermondade, N., Hafhouf, E., Dupont, C., Bechoua, S., Palacios, C., Eustache, F., Poncelet, C., Benzacken, B., Lévy, R., & Sifer, C. (2011) · Human Reproduction · doi:10.1093/humrep/der258 · Cited by 78 · see citing works
Yassine, S., Escoffier, J., Martinez, G., Coutton, C., Karaouzène, T., Zouari, R., Ravanat, J., Metzler‐Guillemain, C., Lee, H. C., Fissore, R. A., et al. (2014) · Molecular Human Reproduction · doi:10.1093/molehr/gau099 · Cited by 77 · see citing works
Molecular cytogenetic and genetic aspects of globozoospermia: a review
Perrin, A., Coat, C., Nguyen, H. M., Talagas, M., Morel, F., Amice, J., & Braekeleer, M. D. (2012) · Andrologia · doi:10.1111/j.1439-0272.2012.01308.x · Cited by 74 · see citing works
Machev, N., Gosset, P., & Viville, S. (2005) · Cytogenetic and Genome Research · doi:10.1159/000086910 · Cited by 69 · see citing works
Stone, S., O’Mahony, F., Khalaf, Y., Taylor, A., & Braude, P. (2000) · Human Reproduction · doi:10.1093/humrep/15.1.139 · Cited by 68 · see citing works
Intracytoplasmic sperm injection (ICSI) in 2006: Evidence and Evolution
The ESHRE Capri Workshop Group (2007) · Human Reproduction Update · doi:10.1093/humupd/dmm024 · Cited by 68 · see citing works
Carrell, D. T., Wilcox, A. L., Udoff, L. C., Thorp, C., & Campbell, B. F. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02904-1 · Cited by 68 · see citing works
Hewitson, L. C., Takahashi, D. L., Dominko, T., Simerly, C. R., & Schatten, G. P. (1998) · Human Reproduction · doi:10.1093/humrep/13.12.3449 · Cited by 67 · see citing works
Chromatin Structure in Globozoospermia: A Case Report
LARSON, K. L., Brannian, J. D., Singh, N. P., Burbach, J. A., Jost, L. K., Hansen, K., Kreger, D. O., & Evenson, D. P. (2001) · Journal of Andrology · doi:10.1002/j.1939-4640.2001.tb02198.x · Cited by 65 · see citing works
Indications for intracytoplasmic sperm injection
Hamberger, L., Lundin, K., Sjogren, A., & Söderlund, B. (1998) · Human Reproduction · doi:10.1093/humrep/13.suppl_1.128 · Cited by 64 · see citing works
Zhu, F., Gong, F., Lin, G., & Lu, G. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat018 · Cited by 61 · see citing works
Reproductive outcome in globozoospermic men: update and prospects
Chansel‐Debordeaux, L., Dandieu, S., Bechoua, S., & Jimenez, C. (2015) · Andrology · doi:10.1111/andr.12081 · Cited by 56 · see citing works
Globozoospermia syndrome: An update
Fesahat, F., Henkel, R., & Agarwal, A. K. (2019) · Andrologia · doi:10.1111/and.13459 · Cited by 56 · see citing works
Disorders at the Testicular Level
Nieschlag, E., Behre, H. M., Wieacker, P. F., Meschede, D., Kamischke, A., & Kliesch, S. (2010) · Springer eBooks · doi:10.1007/978-3-540-78355-8_13 · Cited by 56 · see citing works
Dirican, E. K., Işık, A. Z., Vicdan, K., Sözen, E., & Suludere, Z. (2008) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2008.00248.x · Cited by 55 · see citing works
Garza, S. A. D., & Patrizio, P. (2013) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32835faae5 · Cited by 54 · see citing works
Cellular and molecular events after in vitro fertilization and intracytoplasmic sperm injection
Hewitson, L. C., Simerly, C. R., Dominko, T., & Schatten, G. P. (2000) · Theriogenology · doi:10.1016/s0093-691x(99)00243-5 · Cited by 54 · see citing works
Kyono, K., Nakajo, Y., Nishinaka, C., Hattori, H., Kyoya, T., Ishikawa, T., Abé, H., & Araki, Y. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.10.002 · Cited by 47 · see citing works
Does ICSI require acrosomal disruption? An ultrastructural study
Takeuchi, T. (2003) · Human Reproduction · doi:10.1093/humrep/deg511 · Cited by 47 · see citing works
Aneuploidy in spermatozoa of infertile men with teratozoospermia
Härkönen, K., Suominen, J. J. O., & Lähdetie, J. (2001) · International Journal of Andrology · doi:10.1046/j.1365-2605.2001.00280.x · Cited by 47 · see citing works
Novel DPY19L2 variants in globozoospermic patients and the overcoming this male infertility
Cao, Y.-X., Li, W., Shang, Y.-L., Zhu, F.-X., Yan, J., Chen, L., Tang, W.-H., Xiao, S., Mo, W.-K., Zhang, Z.-G., et al. (2019) · Asian Journal of Andrology · doi:10.4103/aja.aja_79_18 · Cited by 45 · see citing works
Long, R., Wang, M., Yang, Q. Y., Hu, S. Q., Zhu, L., & Jin, L. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-020-00680-2 · Cited by 44 · see citing works
Kashir, J., Sermondade, N., Sifer, C., Oo, S. L., Jones, C., Mounce, G., Turner, K., Child, T. J., McVeigh, E., & Coward, K. (2012) · Human Reproduction · doi:10.1093/humrep/des312 · Cited by 44 · see citing works
The present status of artificial oocyte activation in assisted reproductive technology
Yanagida, K., 藤倉, 洋., & Katayose, H. (2008) · Reproductive Medicine and Biology · doi:10.1111/j.1447-0578.2008.00210.x · Cited by 44 · see citing works
The role and mechanism of action of sperm PLC-zeta in mammalian fertilisation
Nomikos, M., Kashir, J., & Lai, F. A. (2017) · Biochemical Journal · doi:10.1042/bcj20160521 · Cited by 38 · see citing works
Achievement of pregnancy in globozoospermia with Y chromosome microdeletion after ICSI: Case report
Zeyneloğlu, H. B., Baltacı, V., Duran, E. H., Erdemlı, E., & Batıoğlu, S. (2002) · Human Reproduction · doi:10.1093/humrep/17.7.1833 · Cited by 37 · see citing works
Triplet pregnancy and delivery after intracytoplasmic injection of round-headed spermatozoa
Kilani, Z., Shaban, M., Ghunaim, S., Keilani, S. S., & Dakkak, A. (1998) · Human Reproduction · doi:10.1093/humrep/13.8.2177 · Cited by 37 · see citing works
Search for mutations involved in human globozoospermia*
Pirrello, O., Machev, N., Schimdt, F., Terriou, P., Menezo, Y. J. R., & Viville, S. (2005) · Human Reproduction · doi:10.1093/humrep/deh799 · Cited by 36 · see citing works
Teratozoospermia and its effect on male fertility potential
Szczygiel, M. A., & Kurpisz, M. K. (1999) · Andrologia · doi:10.1111/j.1439-0272.1999.tb02848.x · Cited by 32 · see citing works
Nardo, L. G., Sinatra, F., Bartoloni, G., Zafarana, S., & Nardo, F. (2002) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(01)00602-9 · Cited by 27 · see citing works
First successful pregnancy in a globozoospermic patient having homozygous mutation in SPATA16
Karaca, N., Yilmaz, R., Kanter, G. E., Demirci, E., Solakoğlu, S., & Kervancıoglu, E. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.04.002 · Cited by 27 · see citing works
Tanaka, H., Matsuoka, Y., Onishi, M., KITAMURA, K., Miyagawa, Y., Nishimura, H., Tsujimura, A., Okuyama, Ä., & Nishimune, Y. (2005) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00600.x · Cited by 25 · see citing works
Vozdová, M., Rybar, R., Kloudová, S., Přinosilová, P., Texl, P., & Rubeš, J. (2013) · Andrologia · doi:10.1111/and.12156 · Cited by 24 · see citing works
Teratozoospermia influences fertilization rate in vitro but not embryo quality
Terriou, P., Giorgetti, C., Auquier, P., Hans, E., Spach, J. L., Salzmann, J., & Roulier, R. (1997) · Human Reproduction · doi:10.1093/humrep/12.5.1069 · Cited by 24 · see citing works
Higher aneuploidy rates of chromosomes 13, 16, and 21 in a patient with globozoospermia
Ditzel, N., El-Danasouri, I., Just, W., & Sterzik, K. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.01.109 · Cited by 23 · see citing works
Bechoua, S., Chiron, A., Delcleve-Paulhac, S., Sagot, P., & Jimenez, C. (2009) · Andrologia · doi:10.1111/j.1439-0272.2008.00884.x · Cited by 22 · see citing works
Ludwig, M. Z., Al‐Hasani, S., Küpker, W., Bauer, O., & Diedrich, K. (1997) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(97)00128-0 · Cited by 22 · see citing works
Edirisinghe, W. R., Murch, A. R., Junk, S. M., & Yovich, J. L. (1998) · Human Reproduction · doi:10.1093/humrep/13.11.3094 · Cited by 22 · see citing works
Schmiady, H., Schulze, W., Scheiber, I., & Pfüller, B. (2005) · Human Reproduction · doi:10.1093/humrep/deh792 · Cited by 21 · see citing works
Globozoospermia: A Case Report and Systematic Review of Literature
Crafa, A., Condorelli, R. A., Vignera, S. L., Calogero, A. E., & Cannarella, R. (2022) · The World Journal of Men s Health · doi:10.5534/wjmh.220020 · Cited by 19 · see citing works
Intracytoplasmic sperm injection (ICSI) and related technology
Catt, J. (1996) · Animal Reproduction Science · doi:10.1016/0378-4320(96)01481-9 · Cited by 18 · see citing works
Maggiulli, R., Neri, Q. V., Monahan, D., Hu, J., Takeuchi, T., Rosenwaks, Z., & Palermo, G. D. (2010) · Systems Biology in Reproductive Medicine · doi:10.3109/19396361003770321 · Cited by 15 · see citing works
Failure of Fertilization Following Intracytoplasmic Injection of Round-Headed Sperm
Khalili, M. A., Kalantar, S. M., Vahidi, S., & Ghafourzadeh, M. (1998) · Annals of Saudi Medicine · doi:10.5144/0256-4947.1998.408 · Cited by 14 · see citing works
Nasr‐Esfahani, M. H., & Tavalaee, M. (2010) · The Open Andrology Journal · Cited by 14 · see citing works
Yang, X., Wang, J., Liu, J., Gao, Y., Zhou, Z., Sha, J., Zhang, W., Cui, Y., & Qian, X.-Q. (2012) · Asian Journal of Andrology · doi:10.1038/aja.2011.134 · Cited by 11 · see citing works
Self-citationCanepa, P., Casciano, I., Leo, C. D., Massarotti, C., Anserini, P., Remorgida, V., & Scaruffi, P. (2018) · Andrologia · doi:10.1111/and.13178 · Cited by 10 · see citing works
Design of novel oocyte activation methods: the role of zinc
Uh, K., Hay, A. N., Chen, P. R., Reese, E. D., & Lee, K. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab235 · Cited by 9 · see citing works
Zhang, Z.-Q., Long, S.-G., Huang, Z.-H., Xin, C.-L., & Wu, Q. (2015) · Andrologia · doi:10.1111/and.12409 · Cited by 9 · see citing works
Intracytoplasmic sperm injection for treatment of infertility due to acrosomal enzyme deficiency
Abdul-Aziz, M., Meriano, J. S., & Casper, R. F. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58272-7 · Cited by 9 · see citing works
Disorders at the Testicular Level
Nieschlag, E., Behre, H. M., Meschede, D., & Kamischke, A. (2001) · Springer eBooks · doi:10.1007/978-3-662-04491-9_8 · Cited by 9 · see citing works
Carbone, D. J., McMahon, J. T., Levin, H. S., Thomas, A. J., Jr., & Agarwal, A. K. (1998) · Urology · doi:10.1016/s0090-4295(98)00155-1 · Cited by 9 · see citing works
Störungen im Bereich der Testes
Nieschlag, E., Behre, H. M., Meschede, D., & Kamischke, A. (2000) · Springer eBooks · doi:10.1007/978-3-662-05739-1_8 · Cited by 8 · see citing works
CHECK, J. H., Bollendorf, A., & Wilson, C. K. (2016) · Clinical and Experimental Obstetrics & Gynecology · doi:10.12891/ceog3289.2016 · Cited by 6 · see citing works
Morphopathology of Sperm: It's Impact on Fertilization
Franken, D., & Henkel, R. (2012) · Journal of Reproductive and Stem Cell Biotechnology · doi:10.1177/205891581200300102 · Cited by 6 · see citing works
Gosden, L. V., & Yin, H. (2006) · Clinical Obstetrics & Gynecology · doi:10.1097/01.grf.0000197500.99334.20 · Cited by 6 · see citing works
Ludwig, M. Z., & Küpker, W. (1998) · Springer eBooks · doi:10.1007/978-3-642-58738-2_22 · Cited by 5 · see citing works
Catt, J., Ryan, J. P., Pike, I., Porter, R. H., & Saunders, D. M. (1996) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.1996.tb02925.x · Cited by 5 · see citing works
Störungen im Bereich der Testes
Nieschlag, E., Behre, H. M., Wieacker, P. F., Meschede, D., Kamischke, A., & Kliesch, S. (2009) · Springer eBooks · doi:10.1007/978-3-540-92963-5_13 · Cited by 4 · see citing works
ICSI, Male Pronuclear Remodeling and Cell Cycle Checkpoints
Hewitson, L. C., Simerly, C. R., & Schatten, G. P. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9190-4_17 · Cited by 4 · see citing works
Moomjy, M., Sills, E. S., Rosenwaks, Z., & Palermo, G. D. (1999) · The Journal of Urology · doi:10.1016/s0022-5347(01)62016-0 · Cited by 4 · see citing works
Intracytoplasmic Sperm Injection
Palermo, G. D., Pereira, N., Neri, Q. V., Chow, S., Cheung, S. K., & Rosenwaks, Z. (2019) · Springer eBooks · doi:10.1007/978-3-319-43011-9_32 · Cited by 4 · see citing works
“Globe-headed spermatozoa” and ICSI
Rybouchkin, A., Elst, J. V. D., Sutter, P. D., & Dhont, M. A. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00488-3 · Cited by 4 · see citing works
An Andrological Approach to Assisted Reproduction
Köhn, F.-M., & Schill, W. (2000) · Springer eBooks · doi:10.1007/978-3-642-58341-4_9 · Cited by 4 · see citing works
IMSI as a Valuable Tool for Sperm Selection During ART
Antinori, M., Vanderzwalmen, P., & Barak, Y. (2011) · Springer eBooks · doi:10.1007/978-1-4419-8456-2_19 · Cited by 3 · see citing works
Schmiady, H., Pfüller, B., Bloechle, M., & Eckel, H. (2007) · Andrologia · doi:10.1111/j.1439-0272.2006.00750.x · Cited by 3 · see citing works
Different indications for IVF and ICSI
Strowitzki, T. (2000) · Der Gynäkologe · doi:10.1007/s001290050639 · Cited by 3 · see citing works
Oocyte activation: The impact of calcium signals on fertilization
Heytens, E., Soleimani, R., & Sutter, P. D. (2008) · Ghent University Academic Bibliography (Ghent University) · Cited by 3 · see citing works
Geyter, C. D., Geyter, M. D., & Behre, H. M. (2010) · Springer eBooks · doi:10.1007/978-3-540-78355-8_23 · Cited by 3 · see citing works
Intracytoplasmic Injection with Suboptimal Spermatozoa
Palermo, G. D., & Neri, Q. V. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1411-1_2 · Cited by 3 · see citing works
Gatimel, N., Barbotin, A., Mery, L., Beauvillard, D., Bendayan, M., Boursier, A., Boueilh, T., Pereira, B., Chammas, J., Jacquet, J., et al. (2026) · Andrology · doi:10.1111/andr.70134 · Cited by 2 · see citing works
Aston, K. I., & Weimer, K. E. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1436-1_40 · Cited by 2 · see citing works
Ernandez, J. J., Gu, C., & Kathrins, M. N. (2022) · Andrologia · doi:10.1111/and.14474 · Cited by 2 · see citing works
Bafleh, W. S., Abdulsamad, H. M. R., Al-Qaraghuli, S. M., Khatib, R. Y. E., Elbahrawi, R. T., Abdukadir, A. M., Alsawae, S. M., Dimassi, Z., Hamdan, H., & Kashir, J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1198848 · Cited by 2 · see citing works
Geyter, C. D., Geyter, M. D., & Behre, H. M. (2009) · Springer eBooks · doi:10.1007/978-3-540-92963-5_23 · Cited by 2 · see citing works
- Authors
- Liu, J., Nagy, Z., Joris, H., Tournaye, H., Devroey, P., & Van Steirteghem, A.
- Affiliations
- Vrije Universiteit Brussel (BE)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-03
- Volume
- 10
- Issue
- 3
- Pages
- 626-629
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2253903664
- Cited by
- 138
- References
- 0
- Citations by year
- 2025: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 11
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- globozoospermia, intracytoplasmic sperm injection, sperm fertility, male infertility, teratozoospermia, embryonic development, pregnancy outcomes, ectopic pregnancy, twin pregnancy
- MeSH terms
- Acrosome, Adult, Cytoplasm, Embryo Transfer, Female, Fertilization in Vitro, Chorionic Gonadotropin, Humans, Infertility, Male, Male, Microinjections, Middle Aged, Oocytes, Pregnancy, Spermatozoa
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
