Cited by 124Liver Diseases and ImmunityLiver physiology and pathologyDrug Transport and Resistance Mechanisms

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

The pathobiology of biliary epithelia

Roberts, SK, Ludwig, J, Larusso, NF·1997·Gastroenterology

Open this paper in CoChat — free account

Abstract

Our understanding of the pathobiology of biliary epithelia is rapidly growing because of a surge of investigative activity. This became possible after suitable experimental models and techniques were developed with which to study cholangiocyte biology. Although the molecular mechanisms of bile formation by cholangiocytes and the role of these cells as a major cellular target in a variety of severe hepatobiliary diseases are currently being investigated, many questions remain unanswered, particularly regarding cholangiocellular functions, both in normal and abnormal conditions. As current experimental models become more refined, scientists with interests as diverse as cell biology and physiology, morphology, pharmacology, immunology, genetics, and oncology can be expected to further clarify the pathobiology of biliary epithelia.

Integrity signals

Registry

Crossref · 10.1016/s0016-5085(97)70244-0

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Primary Biliary Cirrhosis
Kaplan, M. M. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702263160907 · Cited by 2,016
Detection of Group C Rotavirus in Infants with Extrahepatic Biliary Atresia
Riepenhoff-Talty, M., Gouvêa, V., Evans, M. J., Svensson, L., Hoffenberg, E. J., Sokol, R. J., Uhnoo, I., Greenberg, S. J., Schäkel, K., Zhaori, G., et al. (1996) · The Journal of Infectious Diseases · doi:10.1093/infdis/174.1.8 · Cited by 243
Ductular Reaction in the Livers
Desmet, V. J., Roskams, T., & Eyken, P. V. (1995) · Pathology - Research and Practice · doi:10.1016/s0344-0338(11)80870-8 · Cited by 189
Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver
Dabeva, M. D., Hwang, S. G., Vasa, S. R. G., Hurston, E., Novikoff, P. M., Hixson, D. C., Gupta, S. K., & Shafritz, D. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7356 · Cited by 189
Development and Characterization
Hebsur, M. G. (1998) · NASA Technical Reports Server (NASA) · Cited by 186
Secretin Promotes Osmotic Water Transport in Rat Cholangiocytes by Increasing Aquaporin-1 Water Channels in Plasma Membrane
Marinelli, R. A., Pham, L., Agre, P. C., & LaRusso, N. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.12984 · Cited by 186
Self-citation
Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes
Alpini, G. D., Glaser, S., Rodgers, R., Phinizy, J. L., Robertson, W., Lasater, J., Caligiuri, A., Tretjak, Z., & LeSage, G. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9352879 · Cited by 173
Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs.
Gewirtz, A. T., McCormick, B. A., Neish, A. S., Petasis, N. A., Gronert, K., Serhan, C. N., & Madara, J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1339 · Cited by 158
Hepatic microcirculation and peribiliary plexus in experimental biliary cirrhosis: A morphological study
Gaudio, E., Onori, P., Pannarale, L., & Alvaro, D. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70081-1 · Cited by 111
Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism
Chen, X., Levine, S. A., Tietz, P. S., Krueger, E. W., McNiven, M. A., Jefferson, D. M., Mahle, M., & LaRusso, N. F. (1998) · Hepatology · doi:10.1002/hep.510280402 · Cited by 104
Self-citation

Show all 28 references

Sorted by citations

Enterohepatic Circulation
Roberts, M. S., Magnusson, B. M., Burczynski, F. J., & Weiß, M. (2002) · Clinical Pharmacokinetics · doi:10.2165/00003088-200241100-00005 · Cited by 684
Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism.
Jaiswal, M., LaRusso, N. F., Burgart, L. J., & Gores, G. J. (2000) · PubMed · Cited by 647
Self-citation
MRP3, an organic anion transporter able to transport anti-cancer drugs
Kool, M., van der Linden, M., de Haas, M., Scheffer, G. L., de Vree, J. M. L., Smith, A. J., Jansen, G., Peters, G. J., Ponne, N. J., Scheper, R. J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6914 · Cited by 645
Physiology of Cholangiocytes
Tabibian, J. H., Masyuk, A. I., Masyuk, T. V., O'Hara, S. P., & LaRusso, N. F. (2013) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2013.tb00495.x · Cited by 52
Self-citation
Nitric oxide–mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes
Jaiswal, M., LaRusso, N. F., Shapiro, R. A., Billiar, T. R., & Gores, G. J. (2001) · Gastroenterology · doi:10.1053/gast.2001.20875 · Cited by 230
Self-citation
Interleukin-6 Contributes to Mcl-1 Up-regulation and TRAIL Resistance via an Akt-Signaling Pathway in Cholangiocarcinoma Cells
Kobayashi, S., Werneburg, N. W., Bronk, S. F., Kaufmann, S. H., & Gores, G. J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.010 · Cited by 228
Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line
Park, J., Tadlock, L., Gores, G. J., & Patel, T. C. (1999) · Hepatology · doi:10.1002/hep.510300522 · Cited by 206
Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats
Alvaro, D., Alpini, G. D., Onori, P., Perego, L., Svegliati‐Baroni, G., Franchitto, A., Baiocchi, L., Glaser, S. S., LeSage, G., Folli, F. B., et al. (2000) · Gastroenterology · doi:10.1053/gast.2000.20184 · Cited by 196
Regulation of cholangiocyte bicarbonate secretion
Kanno, N., LeSage, G., Glaser, S. S., & Alpini, G. D. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.3.g612 · Cited by 158
Myofibroblast-derived PDGF-BB promotes hedgehog survival signaling in cholangiocarcinoma cells
Fingas, C. D., Bronk, S. F., Werneburg, N. W., Mott, J. L., Guicciardi, M. E., Cazanave, S. C., Mertens, J. C., Sirica, A. E., & Gores, G. J. (2010) · Hepatology · doi:10.1002/hep.24588 · Cited by 161
Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells
Ishimura, N., Isomoto, H., Bronk, S. F., & Gores, G. J. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00242.2005 · Cited by 155
Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion
LeSage, G., Glaser, S., Gubba, S., Robertson, W., Phinizy, J. L., Lasater, J., Rodgers, R., & Alpini, G. D. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70027-6 · Cited by 152
Localisation of parasite antigens and inflammatory responses in experimental opisthorchiasis
Sripa, B., & Kaewkes, S. (2000) · International Journal for Parasitology · doi:10.1016/s0020-7519(00)00054-0 · Cited by 147
Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties
Lazaridis, K. N., Tietz, P. S., Wu, T., Kip, S. N., Dawson, P. A., & LaRusso, N. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200325297 · Cited by 138
Self-citation
Mechanisms of carbon acquisition for endosymbiont photosynthesis in Anthozoa
Allemand, D., Furla, P., & Tambutté, S. (1998) · Canadian Journal of Botany · doi:10.1139/b98-086 · Cited by 132
Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts
Kruglov, E. A., Nathanson, R. A., Nguyễn, T. T., & Dranoff, J. A. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00308.2005 · Cited by 132
Proinflammatory Cytokines Inhibit Secretion in Rat Bile Duct Epithelium
Spirlı̀, C., Nathanson, M. H., Fiorotto, R., Duner, E., Denson, L. A., Sanz, J. M., Virgilio, F. D., Okolicsànyi, L., Casagrande, F., & Strazzabosco, M. (2001) · Gastroenterology · doi:10.1053/gast.2001.25516 · Cited by 126
Loss of Inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis
Shibao, K., Hirata, K., Robert, M. E., & Nathanson, M. H. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)01201-0 · Cited by 125
Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution
Watson, B. R., Paul, B., Rahman, R. U., Amir-Zilberstein, L., Segerstolpe, Å., Epstein, E. T., Murphy, S., Geistlinger, L., Lee, T., Shih, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55325-4 · Cited by 123
Lipopolysaccharide Induces Cholangiocyte Proliferation Via An Interleukin–6-Mediated Activation of P44/P42 Mitogen–Activated Protein Kinase
Park, J., Gores, G. J., & Patel, T. C. (1999) · Hepatology · doi:10.1002/hep.510290423 · Cited by 123
Regression of cholangiocyte proliferation after cessation of ANIT feeding is coupled with increased apoptosis
LeSage, G., Glaser, S. S., Ueno, Y., Alvaro, D., Baiocchi, L., Kanno, N., Phinizy, J. L., Francis, H., & Alpini, G. D. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.1.g182 · Cited by 121
Acute Carbon Tetrachloride Feeding Selectively Damages Large, But Not Small, Cholangiocytes From Normal Rat Liver
LeSage, G., Benedetti, A., Glaser, S. S., Marucci, L., Tretjak, Z., Caligiuri, A., Rodgers, R., Phinizy, J. L., Baiocchi, L., Francis, H., et al. (1999) · Hepatology · doi:10.1002/hep.510290242 · Cited by 115
Role of crosstalk between interleukin-6 and transforming growth factor-beta 1 in epithelial–mesenchymal transition and chemoresistance in biliary tract cancer
Yamada, D., Kobayashi, S., Wada, H., Kawamoto, K., Marubashi, S., Eguchi, H., Ishii, H., Nagano, H., Doki, Y., & Mori, M. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2012.12.002 · Cited by 115
The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function
Shoda, J., Kano, M., Oda, K., Kamiya, J., Nimura, Y., Suzuki, H., Sugiyama, Y., Miyazaki, H., Todoroki, T., Stengelin, S., et al. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.05339.x · Cited by 112
Regulation and deregulation of cholangiocyte proliferation
Alvaro, D., Gigliozzi, A., & Attili, A. F. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80377-3 · Cited by 112
Inducible Nitric Oxide Synthase Up-Regulates Notch-1 in Mouse Cholangiocytes: Implications for Carcinogenesis
Ishimura, N., Bronk, S. F., & Gores, G. J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.01.055 · Cited by 110
Intracellular pathways mediating estrogen-induced cholangiocyte proliferation in the rat
Alvaro, D., Onori, P., Metalli, V. D., Svegliati‐Baroni, G., Folli, F. B., Franchitto, A., Alpini, G. D., Mancino, M. G., Attili, A. F., & Gaudio, E. (2002) · Hepatology · doi:10.1053/jhep.2002.34741 · Cited by 110
Use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: a morphologic study
Gerlach, J. C., Mutig, K., Sauer, I. M., Schrade, P., Ефимова, Е. А., Mieder, T., Naumann, G., Grünwald, A., Pleß, G., Mas, A., et al. (2003) · Transplantation · doi:10.1097/01.tp.0000083319.36931.32 · Cited by 107
Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia
Dranoff, J. A., Masyuk, A. I., Kruglov, E. A., LaRusso, N. F., & Nathanson, M. H. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.4.g1059 · Cited by 107
Self-citation
The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver
Dranoff, J. A., Kruglov, E. A., Robson, S. C., Braun, N., Zimmermann, H., & Sévigny, J. (2002) · Hepatology · doi:10.1053/jhep.2002.36823 · Cited by 105
Calcium Signaling in the Liver
Amaya, M. J., & Nathanson, M. H. (2012) · Comprehensive physiology · doi:10.1002/cphy.c120013 · Cited by 111
Regulation of cholangiocyte proliferation
LeSage, G., Glaser, S. S., & Alpini, G. D. (2001) · Liver International · doi:10.1034/j.1600-0676.2001.021002073.x · Cited by 95
Effects of bile acids on biliary epithelial cells: Proliferation, cytotoxicity, and cytokine secretion
Lamireau, T., Zoltowska, M., Levy, E. H., Yousef, I. M., Rosenbaum, J., Tuchweber, B., & Desmoulière, A. (2003) · Life Sciences · doi:10.1016/s0024-3205(02)02408-6 · Cited by 91
Dysregulated miR-124 and miR-200 expression contribute to cholangiocyte proliferation in the cholestatic liver by targeting IL-6/STAT3 signalling
Xiao, Y., Wang, J., Yan, W., Zhou, Y., Chen, Y., Zhou, K., Wen, J., Wang, Y., & Cai, W. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.10.033 · Cited by 82
Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes
Gong, A., Tietz, P. S., Muff, M. A., Splinter, P. L., Huebert, R. C., Strowski, M. Z., Chen, X., & LaRusso, N. F. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00313.2002 · Cited by 79
Self-citation
H+-peptide cotransport in the human bile duct epithelium cell line SK-ChA-1
Knütter, I., Rubio‐Aliaga, I., Boll, M., Hause, G., Daniel, H., Neubert, K., & Brandsch, M. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00534.2001 · Cited by 75
Antibody to carbonic anhydrase II is present in primary biliary cirrhosis (PBC) irrespective of antimitochondrial antibody status
Invernizzi, P., Battezzati, P. M., Crosignani, A., Zermiani, P., Bignotto, M., Papa, N. D., Zuin, M. G., & Podda, M. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00735.x · Cited by 72
Quantitative Assessment of the Rat Intrahepatic Biliary System by Three-Dimensional Reconstruction
Masyuk, T. V., Ritman, E. L., & LaRusso, N. F. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64679-2 · Cited by 70
Self-citation
Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytes
Alvaro, D., Gigliozzi, A., Attili, A. F., Onori, P., Franchitto, A., Vetuschi, A., Glaser, S. S., LeSage, G., Alpini, G. D., Morini, S., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.34169 · Cited by 69
Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver
Hirata, K., & Nathanson, M. H. (2001) · Gastroenterology · doi:10.1053/gast.2001.26280 · Cited by 69
Comparative histopathology of Opisthorchis felineus and Opisthorchis viverrini in a hamster model: An implication of high pathogenicity of the European liver fluke
Lvova, M. N., Tangkawattana, S., Balthaisong, S., Katokhin, A. V., Mordvinov, V. A., & Sripa, B. (2011) · Parasitology International · doi:10.1016/j.parint.2011.08.005 · Cited by 69
Enhancer of Zeste Homolog 2 (EZH2) Promotes Progression of Cholangiocarcinoma Cells by Regulating Cell Cycle and Apoptosis
Nakagawa, S., Okabe, H., Sakamoto, Y., Hayashi, H., Hashimoto, D., Yokoyama, N., Sakamoto, K., Kuroki, H., Mima, K., Nitta, H., et al. (2013) · Annals of Surgical Oncology · doi:10.1245/s10434-013-3135-y · Cited by 67
Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth
Ishimura, N., Bronk, S. F., & Gores, G. J. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00539.2003 · Cited by 66
Hepatobiliary Transport: Molecular Mechanisms of Development and Cholestasis
Arrese, M. A., Ananthananarayanan, M., & Suchy, F. J. (1998) · Pediatric Research · doi:10.1203/00006450-199808000-00001 · Cited by 66
A smac mimetic reduces TNF Related Apoptosis Inducing Ligand (TRAIL)‐induced invasion and metastasis of cholangiocarcinoma cells†
Fingas, C. D., Blechacz, B. R. A., Smoot, R. L., Guicciardi, M. E., Mott, J. L., Bronk, S. F., Werneburg, N. W., Sirica, A. E., & Gores, G. J. (2010) · Hepatology · doi:10.1002/hep.23729 · Cited by 64
Molecular aspects of medicine: from experimental to clinical hepatology
Häussinger, D. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.02.001 · Cited by 62
Regulation of cholangiocyte bile secretion
Baiocchi, L., LeSage, G., Glaser, S. S., & Alpini, G. D. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80180-9 · Cited by 62
Mechanisms of biliary carcinogenesis and growth
Wise, C., Pilanthananond, M., Perry, B. F., Alpini, G. D., McNeal, M. J., & Glaser, S. S. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2986 · Cited by 57
Corticosteroids modulate the secretory processes of the rat intrahepatic biliary epithelium
Alvaro, D., Gigliozzi, A., Marucci, L., Alpini, G. D., Barbaro, B., Monterubbianesi, R., Minetola, L., Mancino, M. G., Medina, J. F., Attili, A. F., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.32374 · Cited by 57
Effects of bile acids on biliary epithelial cell proliferation and portal fibroblast activation using rat liver slices
Clouzeau‐Girard, H., Guyot, C., Combe, C., Moronvalle-Halley, V., Housset, C., Lamireau, T., Rosenbaum, J., & Desmoulière, A. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700386 · Cited by 55
Animal models for primary sclerosing cholangitis
Vierling, J. M. (2001) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2001.0207 · Cited by 52
Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation
DeMorrow, S., Francis, H., Gaudio, E., Ueno, Y., Venter, J. K., Onori, P., Franchitto, A., Vaculin, B. T., Vaculin, S., & Alpini, G. D. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00304.2007 · Cited by 53
Targeting PDGFR ‐β in Cholangiocarcinoma
Fingas, C. D., Mertens, J. C., Razumilava, N., Bronk, S. F., Sirica, A. E., & Gores, G. J. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02687.x · Cited by 49
Epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A inhibits the growth of cholangiocarcinoma cells
Nakagawa, S., Sakamoto, Y., OKABE, H., Hayashi, H., Hashimoto, D., Yokoyama, N., Tokunaga, R., Sakamoto, K., Kuroki, H., Mima, K., et al. (2013) · Oncology Reports · doi:10.3892/or.2013.2922 · Cited by 48
Perfused rat intrahepatic bile ducts secrete and absorb water, solute, and ions
Masyuk, A. I., Gong, A., Kip, S. N., Burke, M. J., & LaRusso, N. F. (2000) · Gastroenterology · doi:10.1053/gast.2000.20248 · Cited by 47
Self-citation
Cell‐kinetic study of proliferating bile ductules in various hepatobiliary diseases
Harada, K., Kono, N., Tsuneyama, K., & Nakanuma, Y. (1998) · Liver International · doi:10.1111/j.1600-0676.1998.tb00166.x · Cited by 45
Gastrin reverses established cholangiocyte proliferation and enhanced secretin‐stimulated ductal secretion of BDL rats by activation of apoptosis through increased expression of Ca2+‐dependent PKC isoforms
Glaser, S. S., Alvaro, D., Ueno, Y., Francis, H., Marzioni, M., Phinizy, J. L., Baumann, B., Mancino, M. G., Venter, J. K., LeSage, G., et al. (2003) · Liver International · doi:10.1034/j.1600-0676.2003.00814.x · Cited by 44
TP53-dependent chromosome instability is associated with transient reductions in telomere length in immortal telomerase-positive cell lines
Schwartz, J. L., Jordan, R. T., Liber, H. L., Murnane, J. P., & Evans, H. H. (2001) · Genes Chromosomes and Cancer · doi:10.1002/1098-2264(2000)9999:9999 · Cited by 27
Transport systems in cholangiocytes: their role in bile formation and cholestasis.
Strazzabosco, M. (1997) · PubMed Central · Cited by 43
Polo-like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma
Fingas, C. D., Mertens, J. C., Razumilava, N., Sydor, S., Bronk, S. F., Christensen, J. D., Rizvi, S. H., Canbay, A. E., Treckmann, J. W., Paul, A., et al. (2013) · Hepatology · doi:10.1002/hep.26484 · Cited by 41
Molecular mechanisms of cholestasis: causes and consequences of impaired bile formation
Koopen, N. R., Müller, M. M., Vonk, R. J., Zimniak, P., & Kuipers, F. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(98)00053-2 · Cited by 41
Biology of Cholangiocytes: From Bench to Bedside
Yoo, K.-S., Lım, W., & Choi, H. S. (2016) · Gut and Liver · doi:10.5009/gnl16033 · Cited by 49
L1 Cell Adhesion Molecule Is a Novel Independent Poor Prognostic Factor of Extrahepatic Cholangiocarcinoma
Li, S., Jo, Y. S., Lee, J.-H., Min, J., Lee, E. S., Park, T., Kim, J., & Hong, H. J. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0959 · Cited by 38
Water movement across rat bile duct units is transcellular and channel-mediated
Cova, E., Gong, A.-Y., Marinelli, R. A., & LaRusso, N. F. (2001) · Hepatology · doi:10.1053/jhep.2001.27092 · Cited by 37
Self-citation
Expression of Matrix Metalloproteinase-7 is an Unfavorable Prognostic Factor in Intrahepatic Cholangiocarcinoma
Hirashita, T., Iwashita, Y., Ohta, M., Komori, Y., Eguchi, H., 矢田, 一., & Kitano, S. (2012) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-011-1813-2 · Cited by 35
Suppression of the HPA axis during extrahepatic biliary obstruction induces cholangiocyte proliferation in the rat
Quinn, M. A., Ueno, Y., Pae, H. Y., Huang, L., Frampton, G. A., Galindo, C., Francis, H., Horvat, D., McMillin, M., & DeMorrow, S. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00205.2011 · Cited by 33
Chronic liver disease: current concepts of disease mechanisms
S. A. Center (1999) · Journal of Small Animal Practice · doi:10.1111/j.1748-5827.1999.tb03050.x · Cited by 30
Primary biliary cirrhosis and autoimmune cholangiopathy
Vierling, J. M. (2004) · Clinics in Liver Disease · doi:10.1016/s1089-3261(03)00132-6 · Cited by 28
OVERVIEW OF CHRONIC CHOLESTATIC CONDITIONS IN ADULTS
Sherlock, S. (1998) · Clinics in Liver Disease · doi:10.1016/s1089-3261(05)70004-0 · Cited by 29
Definition and pathology of primary sclerosing cholangitis
Nakanuma, Y., Harada, K., Katayanagi, K., Tsuneyama, K., & Sasaki, M. (1999) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s005340050127 · Cited by 28
Stimulation of bile duct epithelial secretion by glybenclamide in normal and cholestatic rat liver.
Nathanson, M. H., Burgstahler, A. D., Mennone, A., Dranoff, J. A., & Rios–Velez, L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2835 · Cited by 27
Immortalized intrahepatic mouse biliary epithelial cells: Immunologic characterization and immunogenicity
Eiras-Hreha, G., Jefferson, D. M., Yu, C., Grubman, S. A., Alsabeh, R., Geller, S. A., & Vierling, J. M. (1999) · Hepatology · doi:10.1002/hep.510300216 · Cited by 28
Enhancer of zeste homolog 2 (EZH2) regulates tumor angiogenesis and predicts recurrence and prognosis of intrahepatic cholangiocarcinoma
Nakagawa, S., Okabe, H., Ouchi, M., Tokunaga, R., Umezaki, N., Higashi, T., Kaida, T., Arima, K., Kitano, Y., Kuroki, H., et al. (2018) · HPB · doi:10.1016/j.hpb.2018.03.018 · Cited by 23
The role of inositol 1,4,5-trisphosphate receptors in the regulation of bile secretion in health and disease
Pusl, T., & Nathanson, M. H. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.036 · Cited by 24
Low frequency of p53 and ras mutations in bile of patients with hepato‐biliary disease: a prospective study in more than 100 patients
Müller, P., Ostwald, C., Püschel, K., Brinkmann, B., Plath, F., Kröger, J., Barten, M., Nizze, H., Schareck, W. D., Hauenstein, K., et al. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00800.x · Cited by 23
Lack of evidence that bone marrow cells contribute to cholangiocyte repopulation during experimental cholestatic ductal hyperplasia
Moritoki, Y., Ueno, Y., Kanno, N., Yamagiwa, Y., Fukushima, K., Gershwin, M. E., & Shimosegawa, T. (2006) · Liver International · doi:10.1111/j.1478-3231.2006.01250.x · Cited by 22
Cl−-dependent secretory mechanisms in isolated rat bile duct epithelial units
Singh, S. K., Mennone, A., Gigliozzi, A., Fraioli, F., & Boyer, J. L. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.2.g438 · Cited by 22
Heterogeneity of mutant versus wild-type Ki-ras in primary and metastatic colorectal carcinomas, and association of codon-12 valine with early mortality
Al‐Mulla, F., Going, J. J., Sowden, E., Winter, A., Pickford, I. R., & Birnie, G. D. (1998) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199806)185:2 · Cited by 122
Calcium signaling and the secretory activity of bile duct epithelia
Amaya, M. J., & Nathanson, M. H. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.02.003 · Cited by 19
The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1
Frampton, G. A., Ueno, Y., Quinn, M. A., McMillin, M., Pae, H. Y., Galindo, C., Leyva‐Illades, D., & DeMorrow, S. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00104.2012 · Cited by 19
From blood to bile: recent advances in hepatobiliary transport
Arrese, M. A., & Luigi Accatino, L. (2002) · Annals of Hepatology · doi:10.1016/s1665-2681(19)32177-5 · Cited by 18
Interleukin-5 inhibition of biliary cell chloride currents and bile flow
McGill, J. M., Yen, M., Cummings, O. W., Alpini, G. D., LeSage, G., Pollok, K. E., Miller, B., Engle, S. K., & Stansfield, A. P. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.4.g738 · Cited by 18
Amniotic epithelial cell–derived cholangiocytes in experimental cholestatic ductal hyperplasia
Moritoki, Y., Ueno, Y., Kanno, N., Yamagiwa, Y., Fukushima, K., Gershwin, M. E., & Shimosegawa, T. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00049.x · Cited by 17
Evidence of oxidative injury during aging of the liver in a mouse model.
Colantoni, A., Idılman, R., Maria, N. D., Duffner, L. A., Thiel, D. H. V., Witte, P. L., & Kovacs, E. J. (2001) · AGE · doi:10.1007/s11357-001-0007-3 · Cited by 17
Physiology of Cholangiocytes
Masyuk, A. I., Masyuk, T. V., & LaRusso, N. F. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00056-7 · Cited by 16
Self-citation
Human Intrahepatic Biliary Epithelial Cell Lineages: Studies In Vitro
Joplin, R., & Kachilele, S. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-201-4_16 · Cited by 16
Pathogenesis of primary biliary cirrhosis: A unifying model
Kouroumalis, E. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i15.2320 · Cited by 13
Immunohistochemical demonstration of β-naphthoflavone-inducible cytochrome P450 1A1/1A2 in rat intrahepatic biliary epithelial cells
Shen, J., MOY, J. A., Green, M. D., Guengerich, F. P., & Baron, J. (1998) · Hepatology · doi:10.1002/hep.510270604 · Cited by 11
Experimental models to study cholangiocyte biology
Tietz, P. S. (2002) · World Journal of Gastroenterology · doi:10.3748/wjg.v8.i1.1 · Cited by 11
Polo‐like kinase 3 is associated with improved overall survival in cholangiocarcinoma
Juntermanns, B., Sydor, S., Kaiser, G. M., Jaradat, D., Mertens, J. C., Sotiropoulos, G. C., Swoboda, S., Neuhaus, J. P., Meng, W., Máthé, Z., et al. (2015) · Liver International · doi:10.1111/liv.12839 · Cited by 10
Mechanisms of hypotonic inhibition of the sodium, proton exchanger type 1 (NHE1) in a biliary epithelial cell line (Mz‐Cha‐1)
Elsing, C., Gosch, I., Hennings, J. C., Hübner, C. A., & Herrmann, T. R. W. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01682.x · Cited by 10
Role of Vascular Endothelial Growth Factor in Protection of Intrahepatic Cholangiocytes Mediated by Hypoxic Preconditioning After Liver Transplantation in Rats
Zhou, B., Zhang, P.-J., Tian, T., Jin, C., Li, Y., Feng, M., Liu, X.-Y., Jie, L., & Tao, L.-D. (2010) · Transplantation Proceedings · doi:10.1016/j.transproceed.2010.04.028 · Cited by 9
Physiology of Cholangiocytes
Masyuk, A. I., Masyuk, T. V., & LaRusso, N. F. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50062-3 · Cited by 8
Self-citation
L1 Cell Adhesion Molecule Promotes Migration and Invasion via JNK Activation in Extrahepatic Cholangiocarcinoma Cells with Activating KRAS Mutation
Kim, H. J., Hwang, H., Lee, H., & Hong, H. J. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.2282 · Cited by 6
Apical Localization of Inositol 1,4,5-Trisphosphate Receptors Is Independent of Extended Synaptotagmins in Hepatocytes
Amaya, M. J., de Oliveira, A. G., Schroeder, L. K., Allgeyer, E. S., Bewersdorf, J., & Nathanson, M. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114043 · Cited by 6
AUTOIMMUNE CHOLANGIOPATHY
Vierling, J. M. (1999) · Clinics in Liver Disease · doi:10.1016/s1089-3261(05)70085-4 · Cited by 6
Hepatocellular Bile Salt Transport: Lessons from Cholestasis
Trauner, M. A., Fickert, P., & Stauber, R. E. (1999) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2000/870929 · Cited by 6
Development of the Liver and Bile Ducts
Suchy, F. J., & Narkewicz, M. R. (2002) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200207001-00003 · Cited by 5
Three‐dimensional visualization and physiologic evaluation of bile canaliculi in the rat liver slice by confocal laser scanning microscopy
Yoneyama, K. (2001) · Scanning · doi:10.1002/sca.4950230601 · Cited by 5
Signaling Pathways in Biliary Epithelial Cells
Leite, M. F., Andrade, V. A., & Nathanson, M. H. (2009) · Springer eBooks · doi:10.1007/978-3-642-00150-5_2 · Cited by 4

Authors: Roberts, S., Ludwig, J., & Larusso, N.
Affiliations: Mayo Clinic (US)
ORCID: Ludwig, J
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 1997-01
Volume: 112
Issue: 1
Pages: 269-279
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1016/s0016-5085(97)70244-0
OpenAlex: W2062038681
Cited by: 124
References: 28
Citations by year: 2025: 2 · 2023: 3 · 2022: 1 · 2020: 4 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 5
FWCI: 6.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: cholangiocytes, bile formation, hepatobiliary diseases, experimental model, biliary tract physiology
MeSH terms: Autoimmune Diseases, Bile, Bile Duct Diseases, Bile Duct Neoplasms, Bile Ducts, Intrahepatic, Cell Division, Cells, Cultured, Cholangitis, Humans, Liver Cirrhosis, Biliary, Cholangiocarcinoma

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The pathobiology of biliary epithelia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks