The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
The pathobiology of biliary epithelia
Abstract
Our understanding of the pathobiology of biliary epithelia is rapidly growing because of a surge of investigative activity. This became possible after suitable experimental models and techniques were developed with which to study cholangiocyte biology. Although the molecular mechanisms of bile formation by cholangiocytes and the role of these cells as a major cellular target in a variety of severe hepatobiliary diseases are currently being investigated, many questions remain unanswered, particularly regarding cholangiocellular functions, both in normal and abnormal conditions. As current experimental models become more refined, scientists with interests as diverse as cell biology and physiology, morphology, pharmacology, immunology, genetics, and oncology can be expected to further clarify the pathobiology of biliary epithelia.
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“The liver is also composed of non-parenchymal cells, which include hepatic stellate cells (HSCs), resident macrophages, endothelial cells (ECs), and cholangiocytes8,9.”
From Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution (2025) · cites this paper as [9]
Citations
Cites
Kaplan, M. M. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702263160907 · Cited by 2,016
Detection of Group C Rotavirus in Infants with Extrahepatic Biliary Atresia
Riepenhoff-Talty, M., Gouvêa, V., Evans, M. J., Svensson, L., Hoffenberg, E. J., Sokol, R. J., Uhnoo, I., Greenberg, S. J., Schäkel, K., Zhaori, G., et al. (1996) · The Journal of Infectious Diseases · doi:10.1093/infdis/174.1.8 · Cited by 243
Ductular Reaction in the Livers
Desmet, V. J., Roskams, T., & Eyken, P. V. (1995) · Pathology - Research and Practice · doi:10.1016/s0344-0338(11)80870-8 · Cited by 189
Dabeva, M. D., Hwang, S. G., Vasa, S. R. G., Hurston, E., Novikoff, P. M., Hixson, D. C., Gupta, S. K., & Shafritz, D. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7356 · Cited by 189
Development and Characterization
Hebsur, M. G. (1998) · NASA Technical Reports Server (NASA) · Cited by 186
Marinelli, R. A., Pham, L., Agre, P. C., & LaRusso, N. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.12984 · Cited by 186
Self-citationAlpini, G. D., Glaser, S., Rodgers, R., Phinizy, J. L., Robertson, W., Lasater, J., Caligiuri, A., Tretjak, Z., & LeSage, G. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9352879 · Cited by 173
Gewirtz, A. T., McCormick, B. A., Neish, A. S., Petasis, N. A., Gronert, K., Serhan, C. N., & Madara, J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1339 · Cited by 158
Gaudio, E., Onori, P., Pannarale, L., & Alvaro, D. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70081-1 · Cited by 111
Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism
Chen, X., Levine, S. A., Tietz, P. S., Krueger, E. W., McNiven, M. A., Jefferson, D. M., Mahle, M., & LaRusso, N. F. (1998) · Hepatology · doi:10.1002/hep.510280402 · Cited by 104
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Items 101–123 of 123
Gilloteaux, J. (2020) · Translational Research in Anatomy · doi:10.1016/j.tria.2020.100063 · Cited by 3
Elchaninov, A. V., Vishnyakova, P., Glinkina, V. V., Fatkhudinov, T., & Sukhikh, G. T. (2025) · Cells · doi:10.3390/cells14151129 · Cited by 3
Recent Advances in Intrahepatic Biliary Epithelial Heterogeneity
Little, A., Medford, A., O’Brien, A., Childs, J. R., Pan, S., Machado, J., Chakraborty, S., & Glaser, S. S. (2022) · Seminars in Liver Disease · doi:10.1055/s-0042-1758833 · Cited by 3
Tu, K., Zhao, L., Gu, J., Yan, P., Wang, F., & Cao, Y. (2016) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-016-9690-8 · Cited by 3
The Paucity of Interlobular Bile Ducts
Sergi, C. M. (2020) · Springer eBooks · doi:10.1007/978-3-030-24432-3_25 · Cited by 2
Morphology and Microstructure of the Hepatobiliary System
Krishnamurthy, G. T., & Krishnamurthy, S. (2000) · Springer eBooks · doi:10.1007/978-3-662-22654-4_1 · Cited by 2
Lefkowitch, J. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-7020-7584-1.00005-x · Cited by 2
Acquired Alterations of Transporter Expression and Function in Cholestasis
Trauner, M., Fickert, P., & Zollner, G. (2004) · Springer eBooks · doi:10.1007/978-1-4419-9034-1_20 · Cited by 2
Signaling pathways in biliary epithelial cells
Leite, M. F., Guerra, M. T., Andrade, V. A., & Nathanson, M. H. (2015) · doi:10.1002/9781118663387.ch2 · Cited by 2
Lefkowitch, J. H. (2010) · Elsevier eBooks · doi:10.1016/b978-0-7020-3410-7.00011-3 · Cited by 1
Hepatitis C and B virus infection in Chinese patients with extrahepatic bile duct carcinoma
Chen, M., Huang, Z., Chen, L.-Z., Gao, Y., Peng, R., & Wang, D. (2002) · The Chinese-German Journal of Clinical Oncology · doi:10.1007/bf02851789 · Cited by 1
2. FUNCTIONAL HETEROGENEITY OF INTRAHEPATIC CHOLANGIOCYTES
LeSage, G., Glaser, S. S., Francis, H., Phinizy, J. L., & Alpini, G. D. (2004) · Principles of medical biology · doi:10.1016/s1569-2582(04)15002-2
Electrolyte transport in biliary epithelia
Kwiatkowski, A. P., & McGill, J. M. (1997) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(97)90053-6
Morphology and Microstructure of the Hepatobiliary System
Krishnamurthy, G. T., & Krishnamurthy, S. (2009) · Springer eBooks · doi:10.1007/978-3-642-00648-7_1
Hormonal Regulation of Cholangiocyte Secretion
Gigliozzi, A., Fraioli, F., & Boyer, J. L. (2020) · CRC Press eBooks · doi:10.1201/9780367813888-8
Strasberg, S. M., & Hawkins, W. G. (2007) · doi:10.1002/9780470691861.ch19i
Lefkowitch, J. H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-7020-5548-5.00005-0
Dranoff, J. A. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-7107-4_31
Elsing, C., Gosch, I., Hennings, J. C., Hübner, C. A., & Herrmann, T. R. W. (2007) · Acta Physiologica · doi:10.1111/j.1365-201x.2007.01682.x
Hu, D., Min, Y., Heng, L., Lai, J., Zhiqing, Y., Shuai, L., Zhe, S., Hongyu, Z., Leida, Z., Li, Z., et al. (2023) · Medical Research Frontiers · doi:10.57237/j.mrf.2023.01.003
Li, S., Jo, Y. S., Lee, J.-H., Min, J., Lee, E. S., Park, T., Kim, J., & Hong, H. J. (2023) · doi:10.1158/1078-0432.c.6517581
Li, S., Jo, Y. S., Lee, J.-H., Min, J., Lee, E. S., Park, T., Kim, J., & Hong, H. J. (2023) · doi:10.1158/1078-0432.c.6517581.v1
Development of the Liver and Bile Ducts
Suchy, F. J., & Narkewicz, M. R. (2002) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.2002.tb07752.x
Metadata
- Authors
- Roberts, S., Ludwig, J., & Larusso, N.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Ludwig, J
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1997-01
- Volume
- 112
- Issue
- 1
- Pages
- 269-279
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2062038681
- Cited by
- 124
- References
- 28
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 1 · 2020: 4 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 5
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- cholangiocytes, bile formation, hepatobiliary diseases, experimental model, biliary tract physiology
- MeSH terms
- Autoimmune Diseases, Bile, Bile Duct Diseases, Bile Duct Neoplasms, Bile Ducts, Intrahepatic, Cell Division, Cells, Cultured, Cholangitis, Humans, Liver Cirrhosis, Biliary, Cholangiocarcinoma
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