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Cited by 581Stress Responses and CortisolAnimal Behavior and Welfare StudiesAdrenal Hormones and Disorders

The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.

Effects of sex and time of day on metabolism and excretion of corticosterone in urine and feces of mice.

Touma, Chadi, Sachser, Norbert, Möstl, Erich, Palme, Rupert·2003·General and Comparative Endocrinology
DOI 10.1016/s0016-6480(02)00620-2
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Abstract

Non-invasive techniques to monitor stress hormones in small animals like mice offer several advantages and are highly demanded in laboratory as well as in field research. Since knowledge about the species-specific metabolism and excretion of glucocorticoids is essential to develop such a technique, we conducted radiometabolism studies in mice (Mus musculus f. domesticus, strain C57BL/6J). Each mouse was injected intraperitoneally with 740 kBq of 3H-labelled corticosterone and all voided urine and fecal samples were collected for five days. In a first experiment 16 animals (eight of each sex) received the injection at 9 a.m., while eight mice (four of each sex) were injected at 9 p.m. in a second experiment. In both experiments radioactive metabolites were recovered predominantly in the feces, although males excreted significantly higher proportions via the feces (about 73%) than females (about 53%). Peak radioactivity in the urine was detected within about 2h after injection, while in the feces peak concentrations were observed later (depending on the time of injection: about 10h postinjection in experiment 1 and about 4h postinjection in experiment 2, thus proving an effect of the time of day). The number and relative abundance of fecal [3H]corticosterone metabolites was determined by high performance liquid chromatography (HPLC). The HPLC separations revealed that corticosterone was extensively metabolized mainly to more polar substances. Regarding the types of metabolites…

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Research works printed but not linked: 2

  1. Brown, 1997, Faecal steroid analysis for monitoring ovarian and testicular function in diverse wild carnivore, primate and ungulate species, Mamm. Biol. Suppl. II, 62, 27
  2. Warner, 1981, Rate of passage of digesta through the gut of mammals and birds, Nutr. Abstr. Rev. Ser. B, 51, 789

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Metadata

Authors
Touma, C., Sachser, N., Möstl, E., & Palme, R.
Affiliations
  • University of Münster (DE)
  • University of Veterinary Medicine Vienna (AT)
Corresponding author
Touma, Chadi
ORCID
Venue
General and Comparative Endocrinology
Publisher
Elsevier BV
Published
2003-02
Volume
130
Issue
3
Pages
267-278
ISSN
0016-6480 (ISSN-L)
DOI
10.1016/s0016-6480(02)00620-2
OpenAlex
W2011027148
Cited by
581
References
48
Citations by year
2026: 25 · 2025: 22 · 2024: 23 · 2023: 25 · 2022: 40 · 2021: 29 · 2020: 54 · 2019: 45 · 2018: 37 · 2017: 24 · 2016: 28 · 2015: 28 · 2014: 25 · 2013: 26 · 2012: 26
FWCI
4.90
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • General and Comparative Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Behavior and Welfare Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
corticosterone metabolism, glucocorticoid metabolites, sex differences, circadian rhythm, time of day, fecal corticosterone, adrenocortical function, enzyme immunoassay, radiometabolism, mice, C57BL/6J mice
MeSH terms
Animals, Chromatography, High Pressure Liquid, Circadian Rhythm, Corticosterone, Feces, Female, Immunoenzyme Techniques, Kinetics, Male, Mice, Inbred C57BL, Reference Values, Sex Factors, Stress, Physiological, Time Factors, Tritium, Mice

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