Nutrient acquisition by intracellular apicomplexan parasites: staying in for dinner
Abstract
The intracellular forms of the apicomplexan parasites Plasmodium, Toxoplasma and Eimeria reside within a parasitophorous vacuole. The nutrients required by these intracellular parasites to support their high rate of growth and replication originate from the host cell which, in turn, takes up such compounds from the extracellular milieu. Solutes moving from the external medium to the interior of the parasite, are confronted by a series of three membranes --the host cell membrane, the parasitophorous vacuole membrane and the parasite plasma membrane. Each constitutes a potential permeability barrier which must be either crossed or bypassed. It is the mechanisms by which this occurs that are the subject of this review.
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L. amazonensis amastigotes can obtain Tf by forcing the fusion of Tf-containing endosomes with the parasitophorous vacuole.
“L. amazonensis amastigotes can obtain Tf by forcing the fusion of Tf-containing endosomes with the parasitophorous vacuole [86].”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [86]
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- Authors
- Saliba, K. J., & Kirk, K.
- Affiliations
- Australian National University (AU)
- Corresponding author
- Kirk, Kiaran
- Venue
- International Journal for Parasitology
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 31
- Issue
- 12
- Pages
- 1321-1330
- ISSN
- 0020-7519 (ISSN-L)
- OpenAlex
- W2021609444
- Cited by
- 68
- References
- 90
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal for Parasitology (publishedVersion)
- PubMed (publishedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Toxoplasma gondii Research Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Coccidia and coccidiosis research
- Keywords
- nutrient acquisition, Apicomplexa, parasitophorous vacuole, Plasmodium, Toxoplasma, Eimeria, host cell membrane, membrane permeability
- MeSH terms
- Animals, Cell Membrane, Cell Membrane Permeability, Eimeria, Host-Parasite Interactions, Humans, Movement, Plasmodium, Protozoan Infections, Toxoplasma, Vacuoles, Protozoan Proteins, Apicomplexa
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