In vivo metabolism of apolipoprotein E within the HDL subpopulations LpE, LpE:A-I, LpE:A-II and LpE:A-I:A-II
Abstract
High-density lipoproteins can be separated into distinct particles based on their apolipoprotein content. In the present study, the in vivo metabolism of apoE within the apoE-containing HDL particles LpE, LpE:A-I, LpE:A-II and LpE:A-I:A-II was assessed in control subjects and in patients with abetalipoproteinemia (ABL), in whom HDL are the sole plasma lipoproteins. The metabolism of apoE within these HDL subspecies was investigated in three separate studies which differed by donor or recipient status: (1) particles purified from normolipidemic plasma and reassociated with 125I or 131I-labeled apoE injected into normolipidemic subjects (study 1); (2) particles purified from ABL plasma injected into normolipidemic subjects (study 2); and (3) particles purified from ABL plasma injected into ABL subjects (study 3). The plasma residence times (RT, hours) in study 1 were 14.3+/-2.9, 11.3+/-3.4, and 9.1+/-1.2 for apoE within LpE:A-I:A-II, LpE:A-II and LpE:A-I, respectively, while those in study 2 were 10.1+/-2.2, 9.7+/-2.4, 7.9+/-1.0 and 7.3+/-0.8 for apoE within LpE:A-I:A-II, LpE:A-II, LpE:A-I and LpE, respectively. In study 3, RTs for apoE within LpE:A-I:A-II and LpE were 8.7+/-0.9 and 6.8+/-0.9, respectively. In comparison, RT for apoA-I on LpA-I:A-II has been reported to be 124.1+/-5.5 h and that for apoA-I on LpA-I 105.8+/-6.2 h. Thus, apoE within the different apoE-containing HDL particles was metabolized rapidly and at a similar rate in control and ABL subjects. The plasma RT…
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Malmendier et al. reported RTs of 0.60, 0.47, and 0.38 days for 125I-labeled apoE in LpE:A-I:A-II, LpE:A-II, or LpE:A-I particles injected into normolipidemic subjects.
“al. (39) reported RTs of 0.60, 0.47, and 0.38 days for 125 I-labeled apoE in LpE:A-I:A-II, LpE:A-II, or LpE:A-I particles injected into normolipidemic subjects.”
From Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans (2003) · cites this paper as [39]
Cites
High-Density Lipoprotein — The Clinical Implications of Recent Studies
Desforges, J. F., Gordon, D. J., & Rifkind, B. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198911093211907 · Cited by 1,547 · see citing works
Abnormal in vivo metabolism of apolipoprotein E4 in humans.
Gregg, R. E., Zech, L. A., Schaefer, E. J., Stark, D., Wilson, D., & Brewer, H. B. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112645 · Cited by 345 · see citing works
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Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans
Cohn, J. S., Batal, R., Tremblay, M., Jacques, H., Veilleux, L., Rodriguez, C., Mamer, O., & Davignon, J. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300209-jlr200 · Cited by 35 · see citing works
- Authors
- Hannuksela, M. L., Brousseau, M. E., Meyn, S. M., Nazih, H., Bader, G., Shamburek, R. D., Alaupovic, P., & Brewer, H. B.
- Affiliations
- National Institutes of Health (US)
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 165
- Issue
- 2
- Pages
- 205-220
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2060881440
- Cited by
- 15
- References
- 2
- Citations by year
- 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- apolipoprotein E, HDL subpopulations, HDL metabolism, abetalipoproteinemia, plasma residence time, apolipoprotein A-I, lipoprotein clearance
- MeSH terms
- Abetalipoproteinemia, Adult, Apolipoproteins E, Chromatography, Affinity, Electrophoresis, Polyacrylamide Gel, Humans, Lipoproteins, HDL, Male, Apolipoprotein A-I, Apolipoprotein A-II
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