High-Density Lipoprotein — The Clinical Implications of Recent Studies
Abstract
DESPITE early observations suggesting an inverse relation between serum levels of high-density lipoprotein (HDL) cholesterol and coronary disease,1 2 3 the possible protective role of HDL in atherogenesis received little attention until its "rediscovery" by Miller and Miller4 in 1975 and the publication of confirmatory results from the Honolulu,5 Framingham,6 and Tromsø7 heart studies in 1976 and 1977. In the ensuing decade, research into the biochemistry, metabolism, epidemiology, and genetics of HDL has expanded rapidly, but many questions remain unanswered. The recent publication of the results of the Helsinki Heart Study8 , 9 — in which simultaneous 11 percent increases in HDL and reductions . . .
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There is an inverse relationship between serum HDL levels and the risk of coronary heart disease.
“there is an inverse relationship between serum HDL levels and the risk of coronary heart disease49,50.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [50]
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- Authors
- Desforges, J. F., Gordon, D. J., & Rifkind, B. M.
- Affiliations
- National Heart, Lung, and Blood Institute (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1989-11-09
- Volume
- 321
- Issue
- 19
- Pages
- 1311-1316
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2339616051
- Cited by
- 1,547
- References
- 50
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 15 · 2023: 19 · 2022: 13 · 2021: 22 · 2020: 22 · 2019: 30 · 2018: 21 · 2017: 24 · 2016: 36 · 2015: 47 · 2014: 42 · 2013: 42 · 2012: 38
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- high-density lipoprotein, HDL cholesterol, coronary artery disease, atherogenesis, cardioprotection, HDL metabolism, Helsinki Heart Study
- MeSH terms
- Coronary Disease, Humans, Lipoproteins, HDL, Cholesterol, HDL
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