The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women
Abstract
Physical activity (PA) is associated with a reduced risk of coronary heart disease, and may favorably modify the antioxidant-prooxidant balance. This study assessed the effects of aerobic PA training on antioxidant enzyme activity, oxidized LDL concentration, and LDL resistance to oxidation, as well as the effect of acute PA on antioxidant enzyme activity before and after the training period. Seventeen sedentary healthy young men and women were recruited for 16 weeks of training. The activity of superoxide dismutase in erythrocytes (E-SOD), glutathione peroxidase in whole blood (GSH-Px), and glutathione reductase in plasma (P-GR), and the oxidized LDL concentration and LDL composition, diameter, and resistance to oxidation were determined before and after training. Shortly before and after this training period they also performed a bout of aerobic PA for 30 min. The antioxidant enzyme activity was also determined at 0 min, 30 min, 60 min, 120 min, and 24 h after both bouts of PA. Training induces an increase in GSH-Px (27.7%), P-GR (17.6%), and LDL resistance to oxidation, and a decrease in oxidized LDL (-15.9%). After the bout of PA, an increase in E-SOD and GSH-Px was observed at 0 min, with a posterior decrease in enzyme activity until 30-60 min, and a tendency to recover the basal values at 120 min and 24 h. Training did not modify this global response pattern. Regular PA increases endogenous antioxidant activity and LDL resistance to oxidation, and decreases oxidized LDL concentration; 30 min of aerobic PA decreases P-GR and B-GSH-Px activity in the first 30-60 min with a posterior recovery.
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“Varady et al. [40] found that the LDL particle volume decreased in patients with hypercholesterolemia after aerobic exercise.”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [40]
In the citing paper
“Elosua et al. [40] suggested that aerobic exercise had no effect on LDL particle diameter.”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [40]
Citations
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Research works printed but not linked: 1
- Gutteridge, 1995, Lipid peroxidation and antioxidants as biomarkers of tissue damage, Clin. Chem., 41, 1819, 10.1093/clinchem/41.12.1819 · DOI
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Oxidative Stress: Relationship with Exercise and Training
Finaud, J., Lac, G., & Filaire, E. (2006) · Sports Medicine · doi:10.2165/00007256-200636040-00004 · Cited by 771
Acute exercise and oxidative stress: a 30 year history
Fisher‐Wellman, K. H., & Bloomer, R. J. (2009) · Dynamic Medicine · doi:10.1186/1476-5918-8-1 · Cited by 684
Effects of aerobic exercise on lipids and lipoproteins
Wang, Y., & Xu, D. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0515-5 · Cited by 436
Correlation between Oxidative Stress, Nutrition, and Cancer Initiation
Saha, S. K., Lee, S. B., Won, J., Choi, H. Y., Kim, K., Yang, G., Dayem, A. A., & Cho, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071544 · Cited by 416
The power of exercise: buffering the effect of chronic stress on telomere length
Puterman, E., Lin, J., Blackburn, E., O'Donovan, A., Adler, N., & Epel, E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010837 · Cited by 339
Metadata
- Authors
- Elosua, R., Molina, L., Fito, M., Arquer, A., Sanchez-Quesada, J. L., Covas, M. I., Ordoñez-Llanos, J., & Marrugat, J.
- ORCID
- Marrugat, J
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 167
- Issue
- 2
- Pages
- 327-334
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2103973623
- Cited by
- 286
- References
- 37
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 13 · 2023: 16 · 2022: 6 · 2021: 8 · 2020: 12 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 15 · 2015: 16 · 2014: 18 · 2013: 13 · 2012: 18
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Update notices
- erratum (2008-04-01)
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- aerobic physical activity, oxidative stress, antioxidant enzymes, superoxide dismutase, glutathione peroxidase, glutathione reductase, oxidized LDL, LDL oxidation resistance, acute exercise, sedentary young adults, erythrocytes, coronary heart disease risk
- MeSH terms
- Adult, Female, Glutathione Peroxidase, Humans, Lipoproteins, LDL, Male, Oxidation-Reduction, Particle Size, Physical Education and Training, Physical Fitness, Probability, Reference Values, Sensitivity and Specificity, Superoxide Dismutase, Time Factors, Lipid Peroxidation, Cohort Studies, Biomarkers, Exercise, Linear Models, Oxidative Stress
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