The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
The influence of DNA and nucleosome structure on integration events directed by HIV integrase
Open accessAbstract
DNA copies of the human immunodeficiency virus (HIV) genome integrate nonrandomly into the chromosomal DNA of the host cell. In this report, we investigate the molecular basis of this selectivity using the virus-encoded HIV integrase to direct integration of a synthetic HIV long terminal repeat substrate into either DNA molecules of known structure or previously defined nucleosomal complexes. We find that the structure of the target greatly influences the site of integration, and, moreover, DNA curvature, flexibility, and rigidity in solution all influence the frequency of integration. Importantly, for DNA with all of these properties, the distortion of the double helix directed by association with the histone proteins promotes the integration reaction and alters the distribution of sites that are selected for integration. We suggest that both intrinsic DNA structure and the folding of DNA into chromosomal structures will exert a major influence on target site selection for integration of the viral genome.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It has been observed that PIC or the intasome have greater inclination to integrate into bent target DNA that is wrapped with histones or transcription factors in comparison to the naked DNA (Müller and Varmus 1994, Pruss et al. 1994, Maskell et al. 2015, Matysiak et al. 2017).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Pruss et al. 1994
Citations
Cites
Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
A new method for sequencing DNA.
Maxam, A. M., & Gilbert, W. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.2.560 · Cited by 7,929
NUCLEASE HYPERSENSITIVE SITES IN CHROMATIN
Gross, D. S., & Garrard, W. T. (1988) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.57.070188.001111 · Cited by 1,233
Structure of the nucleosome core particle at 7 Å resolution
Richmond, T. J., Finch, J. T., Rushton, B., Rhodes, D., & Klug, A. (1984) · Nature · doi:10.1038/311532a0 · Cited by 1,061
The structure of an oligo(dA)·oligo(dT) tract and its biological implications
Nelson, H. C. M., Finch, J. T., Luisi, B. F., & Klug, A. (1987) · Nature · doi:10.1038/330221a0 · Cited by 979
Sequence periodicities in chicken nucleosome core DNA
Satchwell, S. C., Drew, H. R., & TRAVERS, A. A. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90452-3 · Cited by 929
Structure of a B-DNA dodecamer
Drew, H. R., & Dickerson, R. E. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90009-7 · Cited by 921
Coll, M., Frederick, C., Wang, A. H. ‐., & Rich, A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8385 · Cited by 685
Reversible bending and helix geometry in a B-DNA dodecamer: CGCGAATTBrCGCG.
Fratini, A. V., Kopka, M. L., Drew, H. R., & Dickerson, R. E. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33335-0 · Cited by 626
Bent helical structure in kinetoplast DNA
Marini, J. C., Levene, S. D., Crothers, D. M., & Englund, P. T. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7664 · Cited by 596
Research works printed but not linked: 3
- Huibregtse, 1987, Mol. Cell. Biol., 7, 3212
- Kassavetis, 1989, Mol. Cell. Biol., 9, 2551
- Morse, 1992, Mol. Cell. Biol., 12, 4015
Cited by
Sorted by citations
HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots
Schröder, A. R. W., Shinn, P., Chen, H., Berry, C., Ecker, J. R., & Bushman, F. (2002) · Cell · doi:10.1016/s0092-8674(02)00864-4 · Cited by 1,832
Self-citationTranscription Start Regions in the Human Genome Are Favored Targets for MLV Integration
Wu, X., Li, Y., Crise, B., & Burgess, S. M. (2003) · Science · doi:10.1126/science.1083413 · Cited by 1,305
Kim, J. M., Vanguri, S., Boeke, J. D., Gabriel, A., & Voytas, D. F. (1998) · Genome Research · doi:10.1101/gr.8.5.464 · Cited by 534
Wang, G. P., Ciuffi, A., Leipzig, J., Berry, C. C., & Bushman, F. D. (2007) · Genome Research · doi:10.1101/gr.6286907 · Cited by 457
Self-citationGenome-wide analysis of retroviral DNA integration
Bushman, F. D., Lewinski, M. K., Ciuffi, A., Barr, S. D., Leipzig, J. N., Hannenhalli, S. S., & Hoffmann, C. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1263 · Cited by 437
Self-citationHigh-Resolution Genome-Wide Mapping of Transposon Integration in Mammals
Yant, S. R., Wu, X., Huang, Y., Garrison, B. S., Burgess, S. M., & Kay, M. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.6.2085-2094.2005 · Cited by 322
TARGET SITE SELECTION IN TRANSPOSITION
Craig, N. L. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.437 · Cited by 288
Vigdal, T. J., Kaufman, C. D., Izsvák, Z., Voytas, D. F., & Ivics, Z. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00991-9 · Cited by 259
Nuclear functions of the HMG proteins
Reeves, R. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.09.001 · Cited by 256
Self-citationIntegrase and integration: biochemical activities of HIV-1 integrase
Delelis, O., Carayon, K., Saı̈b, A., Deprez, E., & Mouscadet, J. F. (2008) · Retrovirology · doi:10.1186/1742-4690-5-114 · Cited by 261
Lesbats, P., Engelman, A., & Cherepanov, P. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00125 · Cited by 250
Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes
Eidahl, J. O., Crowe, B. L., North, J. A., McKee, C. J., Shkriabai, N., Feng, L., Plumb, M., Graham, R. L., Gorelick, R. J., Hess, S., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt074 · Cited by 207
HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2
Ocwieja, K. E., Brady, T. L., Ronen, K., Huegel, A., Roth, S. L., Schaller, T., James, L. C., Towers, G. J., Young, J. A. T., Chanda, S. K., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001313 · Cited by 212
Self-citationThe Interaction of LEDGF/p75 with Integrase Is Lentivirus-specific and Promotes DNA Binding
Busschots, K., Vercammen, J., Emiliani, S., Benarous, R., Engelborghs, Y., Christ, F., & Debyser, Z. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411681200 · Cited by 208
HISTONE STRUCTURE AND THE ORGANIZATION OF THE NUCLEOSOME
Ramakrishnan, V. (1997) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.26.1.83 · Cited by 174
Genome-Wide Analyses of Avian Sarcoma Virus Integration Sites
Narezkina, A., Taganov, K. D., Litwin, S., Stoyanova, R. S., Hayashi, J., Seeger, C., Skalka, A. M., & Katz, R. A. (2004) · Journal of Virology · doi:10.1128/jvi.78.21.11656-11663.2004 · Cited by 157
Wu, X., Li, Y., Crise, B. J., Burgess, S. M., & Munroe, D. J. (2005) · Journal of Virology · doi:10.1128/jvi.79.8.5211-5214.2005 · Cited by 149
Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase
Golding, A., Chandler, S. P., Ballestar, E., Wolffe, A. P., & Schlissel, M. S. (1999) · The EMBO Journal · doi:10.1093/emboj/18.13.3712 · Cited by 151
Self-citationHeuer, T. S., & Brown, P. O. (1998) · Biochemistry · doi:10.1021/bi972949c · Cited by 148
Carteau, S., Hoffmann, C. J., & Bushman, F. D. (1998) · Journal of Virology · doi:10.1128/jvi.72.5.4005-4014.1998 · Cited by 144
Self-citationHIV integration site distributions in resting and activated CD4 + T cells infected in culture
Brady, T., Agosto, L. M., Malani, N., Berry, C. C., O’Doherty, U., & Bushman, F. D. (2009) · AIDS · doi:10.1097/qad.0b013e32832caf28 · Cited by 154
Self-citationWang, G. P., Levine, B. L., Binder, G. K., Berry, C. C., Malani, N., McGarrity, G., Tebas, P., June, C. H., & Bushman, F. D. (2009) · Molecular Therapy · doi:10.1038/mt.2009.16 · Cited by 147
Self-citationRetroviral DNA Integration—Mechanism and Consequences
Lewinski, M. K., & Bushman, F. D. (2005) · Advances in genetics · doi:10.1016/s0065-2660(05)55005-3 · Cited by 140
Self-citationMolecular mechanisms of retroviral integration site selection
Kvaratskhelia, M., Sharma, A., Larue, R. C., Serrao, E., & Engelman, A. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku769 · Cited by 150
Positioning and stability of nucleosomes on MMTV 3′LTR sequences
Flaus, A., & Richmond, T. J. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1464 · Cited by 132
Silent chromatin determines target preference of the Saccharomyces retrotransposon Ty5
Zou, S., & Voytas, D. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7412 · Cited by 128
Integrase, LEDGF/p75 and HIV replication
Poeschla, E. M. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7540-5 · Cited by 140
Perpetually mobile footprints of ancient infections in human genome
Sverdlov, E. D. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00478-5 · Cited by 129
Retroviral DNA integration: HIV and the role of LEDGF/p75.
Ciuffi, A., & Bushman, F. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.05.006 · Cited by 134
Self-citationYang, Z., Mueser, T. C., Bushman, F. D., & Hyde, C. C. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3463 · Cited by 118
Self-citationMeekings, K. N., Leipzig, J. N., Bushman, F. D., Taylor, G. P., & Bangham, C. R. M. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000027 · Cited by 113
Self-citationBushman, F. D., & Miller, M. D. (1997) · Journal of Virology · doi:10.1128/jvi.71.1.458-464.1997 · Cited by 112
Self-citationJiang, N., & Wessler, S. R. (2001) · The Plant Cell · doi:10.1105/tpc.010235 · Cited by 112
Reeves, R. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.09.015 · Cited by 110
Self-citationA large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration
Wei, S., Mizuuchi, K., & Craigie, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7511 · Cited by 102
Genome-wide mapping of foamy virus vector integrations into a human cell line.
Nowrouzi, A., Dittrich, M., Klanke, C., Heinkelein, M., Rammling, M., Dandekar, T., von Kalle, C., & Rethwilm, A. (2006) · Journal of General Virology · doi:10.1099/vir.0.81554-0 · Cited by 113
Goulaouic, H., & Chow, S. A. (1996) · Journal of Virology · doi:10.1128/jvi.70.1.37-46.1996 · Cited by 97
Structural basis for HIV‐1 DNA integration in the human genome, role of the LEDGF/P75 cofactor
Michel, F., Crucifix, C., Granger, F., Eiler, S., Mouscadet, J. F., Korolev, S. V., Agapkina, J., Ziganshin, R., Gottikh, M., Nazabal, A., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.41 · Cited by 114
Retroviral Integrase Structure and DNA Recombination Mechanism
Engelman, A., & Cherepanov, P. (2014) · Microbiology Spectrum · doi:10.1128/microbiolspec.mdna3-0024-2014 · Cited by 101
Cellular and molecular mechanisms of HIV-1 integration targeting
Engelman, A., & Singh, P. K. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2772-5 · Cited by 102
Gerton, J. L., Ohgi, S., Olsen, M. N., DeRisi, J. L., & Brown, P. O. (1998) · Journal of Virology · doi:10.1128/jvi.72.6.5046-5055.1998 · Cited by 86
Interactions between Retroviruses and the Host Cell Genome
Poletti, V., & Mavilio, F. (2017) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2017.10.001 · Cited by 85
Integration target site selection for retroviruses and transposable elements
Wu, X., & Burgess, S. M. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4206-9 · Cited by 83
Violot, S., Hong, S. S., Rakotobe, D., Petit, C., Gay, B., Moreau, K., Billaud, G., Priet, S., Sire, J., Schwartz, O., et al. (2003) · Journal of Virology · doi:10.1128/jvi.77.23.12507-12522.2003 · Cited by 80
Studamire, B., & Goff, S. P. (2008) · Retrovirology · doi:10.1186/1742-4690-5-48 · Cited by 85
Retroviral integration site selection
Desfarges, S., & Ciuffi, A. (2010) · Viruses · doi:10.3390/v2010111 · Cited by 78
Chromatin regulation of virus infection
Lieberman, P. M. (2006) · Trends in Microbiology · doi:10.1016/j.tim.2006.01.001 · Cited by 77
Disruption of the terminal base pairs of retroviral DNA during integration.Preprint
Scottoline, B. P., Chow, S. A., Ellison, V., & Brown, P. O. (1997) · Genes & Development · doi:10.1101/gad.11.3.371 · Cited by 75
Target DNA chromatinization modulates nicking by L1 endonuclease
Cost, G. J. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.2.573 · Cited by 74
Integration Site Selection by Retroviral Vectors: Molecular Mechanism and Clinical Consequences
Daniel, R., & Smith, J. A. (2008) · Human Gene Therapy · doi:10.1089/hum.2007.148 · Cited by 74
Central Core Domain of Retroviral Integrase Is Responsible for Target Site Selection
hio Shibagaki, Y., & Chow, S. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8361 · Cited by 73
Reeves, R., & Wolffe, A. P. (1996) · Biochemistry · doi:10.1021/bi952424p · Cited by 73
Self-citationHIV-1 Integrase as a Target for Antiviral Drugs
Pommier, Y. G., Pilon, A. A., Bajaj, K., Mazumder, A., & Neamati, N. (1997) · Antiviral chemistry & chemotherapy · doi:10.1177/095632029700800601 · Cited by 73
Gandapu, U., Chaitanya, R. K., Golla, K., Reddy, R. C., & Kondapi, A. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023388 · Cited by 72
Lesbats, P., Botbol, Y. M., Chevereau, G., Vaillant, C., Calmels, C., Arnéodo, A., Andréola, M., Lavigne, M., & Parissi, V. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001280 · Cited by 87
Gammaretroviral Integration into Nucleosomal Target DNA In Vivo
Roth, S. L., Malani, N., & Bushman, F. D. (2011) · Journal of Virology · doi:10.1128/jvi.00635-11 · Cited by 69
Self-citationMack, K. D., Jin, X., Yu, S., Wei, R., Kapp, L. N., Green, C., HERNDIER, B. G., Abbey, N. W., Elbaggari, A., Liu, Y., et al. (2003) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200307010-00004 · Cited by 66
Papayannakos, C. J., & Daniel, R. (2012) · Gene Therapy · doi:10.1038/gt.2012.88 · Cited by 68
Botbol, Y. M., Raghavendra, N. K., Rahman, S., Engelman, A., & Lavigne, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1127 · Cited by 63
Key determinants of target DNA recognition by retroviral intasomes
Serrao, E., Ballandras-Colas, A., Cherepanov, P., Maertens, G. N., & Engelman, A. N. (2015) · Retrovirology · doi:10.1186/s12977-015-0167-3 · Cited by 62
Physical principles of retroviral integration in the human genome
Michieletto, D., Lušić, M., Marenduzzo, D., & Orlandini, E. (2019) · Nature Communications · doi:10.1038/s41467-019-08333-8 · Cited by 64
A Preferred Target DNA Structure for Retroviral Integrasein Vitro
Katz, R. A., Gravuer, K., & Skalka, A. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.24190 · Cited by 61
BARE-1 insertion site preferences and evolutionary conservation of RNA and cDNA processing sites
Suoniemi, A., Schmidt, D., & Schulman, A. H. (1997) · Contemporary issues in genetics and evolution · doi:10.1007/978-94-011-4898-6_22 · Cited by 62
Serrao, E., Krishnan, L., Shun, M.-C., Li, X., Cherepanov, P., Engelman, A., & Maertens, G. N. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku136 · Cited by 59
Chromatin dynamics associated with HIV-1 Tat-activated transcription
Easley, R. L., Duyne, R. V., Coley, W., Guendel, I., Dadgar, S., Kehn‐Hall, K., & Kashanchi, F. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.08.008 · Cited by 58
Bor, Y.-C., Bushman, F. D., & Orgel, L. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10334 · Cited by 57
Self-citationTelomeres, histone code, and DNA damage response
Misri, S., Pandita, S., Kumar, R., & Pandita, T. K. (2008) · Cytogenetic and Genome Research · doi:10.1159/000167816 · Cited by 54
Deciphering the Code for Retroviral Integration Target Site Selection
Santoni, F. A., Hartley, O., & Luban, J. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1001008 · Cited by 55
A Three-dimensional Model of the Human Immunodeficiency Virus Type 1 Integration Complex
Wielens, J., Crosby, I. T., & Chalmers, D. K. (2005) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-005-5256-2 · Cited by 54
The Core Domain of HIV-1 Integrase Recognizes Key Features of Its DNA Substrates
Gerton, J. L., & Brown, P. O. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25809 · Cited by 55
Human Immunodeficiency Virus Integration Efficiency and Site Selection in Quiescent CD4 + T Cells
Vatakis, D. N., Kim, S., Kim, N., Chow, S. A., & Zack, J. A. (2009) · Journal of Virology · doi:10.1128/jvi.00356-09 · Cited by 52
Integration site selection by lentiviruses: biology and possible control.
Bushman, F. D. (2002) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-56114-6_8 · Cited by 58
Self-citationTwo independent retrotransposon insertions at the same site within the coding region of BTK
Conley, M. E., Partain, J., Norland, S. M., Shurtleff, S. A., & Kazazian, H. H. (2005) · Human Mutation · doi:10.1002/humu.9321 · Cited by 50
Retroviral Vectors: Post Entry Events and Genomic Alterations
Nowrouzi, A., Glimm, H., Kalle, C. V., & Schmidt, M. (2011) · Viruses · doi:10.3390/v3050429 · Cited by 48
2 Molecular genetics and target site specificity of retroviral integration
Holmes-Son, M. L., Appa, R. S., & Chow, S. A. (2001) · Advances in genetics · doi:10.1016/s0065-2660(01)43003-3 · Cited by 48
Intasome architecture and chromatin density modulate retroviral integration into nucleosome
Benleulmi, M. S., Matysiak, J., Henriquez, D. R., Vaillant, C., Lesbats, P., Calmels, C., Naughtin, M., Leon, O., Skalka, A. M., Ruff, M., et al. (2015) · Retrovirology · doi:10.1186/s12977-015-0145-9 · Cited by 47
A Homology Model of HIV-1 Integrase and Analysis of Mutations Designed to Test the Model
Johnson, B. C., Métifiot, M., Ferris, A. L., Pommier, Y. G., & Hughes, S. H. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.03.027 · Cited by 46
Wang, W., Fasolino, M., Cattau, B., Goldman, N., Kong, W., Frederick, M. A., McCright, S. J., Kiani, K., Fraietta, J. A., & Vahedi, G. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919259117 · Cited by 47
Recognition of triple-helical DNA structures by transposon Tn 7
Rao, J. E., Miller, P. S., & Craig, N. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080061497 · Cited by 47
Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration
Matysiak, J., Lesbats, P., Mauro, E., Lapaillerie, D., Dupuy, J., Lopez, A. P., Benleulmi, M. S., Calmels, C., Andréola, M., Ruff, M., et al. (2017) · Retrovirology · doi:10.1186/s12977-017-0363-4 · Cited by 47
Methods for integration site distribution analyses in animal cell genomes
Ciuffi, A., Ronen, K., Brady, T., Malani, N., Wang, G., Berry, C. C., & Bushman, F. D. (2008) · Methods · doi:10.1016/j.ymeth.2008.10.028 · Cited by 46
Self-citationHost Factors in Retroviral Integration and the Selection of Integration Target Sites
Craigie, R., & Bushman, F. D. (2014) · Microbiology Spectrum · doi:10.1128/microbiolspec.mdna3-0026-2014 · Cited by 49
Self-citationThe Roles of Cellular Factors in Retroviral Integration
Engelman, A. (2003) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-19012-4_6 · Cited by 45
Gijsbers, R., Vets, S., Rijck, J. D., Ocwieja, K. E., Ronen, K., Malani, N., Bushman, F. D., & Debyser, Z. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.255711 · Cited by 46
Self-citationRetractedBare-1 insertion site preferences and evolutionary conservation of RNA and cDNA processing sites
Suoniemi, A., Schmidt, D., & Schulman, A. H. (1997) · Genetica · doi:10.1023/a:1018398016018 · Cited by 44
Factors that mold the nuclear landscape of HIV-1 integration
Bedwell, G. J., & Engelman, A. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1207 · Cited by 42
Substrate Recognition by Retroviral Integrases
Katzman, M., & Katz, R. A. (1999) · Advances in virus research · doi:10.1016/s0065-3527(08)60307-3 · Cited by 43
Stereospecificity of Reactions Catalyzed by HIV-1 Integrase
Gerton, J. L., Herschlag, D., & Brown, P. O. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33480 · Cited by 41
DNA distortion as a factor in nucleosome positioning 1 1Edited by A. Klug
Fitzgerald, D. J., & Anderson, J. N. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3171 · Cited by 41
Local Definition of Ty1 Target Preference by Long Terminal Repeats and Clustered tRNA GenesPreprint
Bachman, N., Eby, Y. J., & Boeke, J. D. (2004) · Genome Research · doi:10.1101/gr.2052904 · Cited by 39
Mammalian Retroposons Integrate at Kinkable DNA Sites
Jurka, J., Klonowski, P., & Trifonov, E. N. (1998) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.1998.10508987 · Cited by 37
Appa, R. S., Shin, C., Lee, P., & Chow, S. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107365200 · Cited by 36
Tying together integration and chromatin
Curcio, M. J., & Morse, R. H. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)30107-8 · Cited by 35
Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration
Jones, N. D., Lopez, M. A., Hanne, J., Peake, M. B., Lee, J., Fishel, R. A., & Yoder, K. E. (2016) · Nature Communications · doi:10.1038/ncomms11409 · Cited by 33
Retroviral cDNA Integration: Mechanism, Applications and Inhibition
Hansen, M. S. T., Carteau, S., Hoffmann, C. J., Li, L., & Bushman, F. D. (1998) · Springer eBooks · doi:10.1007/978-1-4899-1739-3_3 · Cited by 33
Self-citationDang, V., Benedik, M. J., Ekwall, K., Choi, J., Allshire, R. C., & Levin, H. L. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2351 · Cited by 32
Target DNA capture by HIV-1 integration complexes
Miller, M. D., Bor, Y.-C., & Bushman, F. D. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00209-0 · Cited by 32
Self-citationTelomeres and meiosis in health and disease
Pandita, T. K., Hunt, C. R., Sharma, G. G., & Yang, Q. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6465-0 · Cited by 32
Vanderlinden, W., Lipfert, J., Demeulemeester, J., Debyser, Z., & Feyter, S. D. (2014) · Nanoscale · doi:10.1039/c4nr00022f · Cited by 31
Matrix attachment regions as targets for retroviral integration
Johnson, C., & Levy, L. S. (2005) · Virology Journal · doi:10.1186/1743-422x-2-68 · Cited by 30
Metadata
- Authors
- Pruss, D., Reeves, R., Bushman, F. D., & Wolffe, A. P.
- Affiliations
- National Institutes of Health (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1994-10
- Volume
- 269
- Issue
- 40
- Pages
- 25031-25041
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1569658633
- Cited by
- 173
- References
- 63
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 2 · 2012: 2
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- HIV integrase, viral DNA integration, target site selection, nucleosome structure, DNA curvature, DNA flexibility, histone proteins, long terminal repeat, chromatin
- MeSH terms
- Base Sequence, DNA, DNA Nucleotidyltransferases, HIV, Molecular Sequence Data, Nucleosomes, Virus Integration, Integrases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review