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Functional identification of a vesicular acetylcholine transporter and its expression from a “cholinergic” gene locus.
Open accessAbstract
The vesicular acetylcholine transporter (VAChT) has been identified and characterized based on the acquisition of high affinity vesamicol binding and proton-dependent, vesamicol-sensitive acetylcholine accumulation by a fibroblast cell line transfected with a clone from a rat pheochromocytoma cDNA library encoding this protein. The distribution of VAChT mRNA coincides with that reported for choline acetyltransferase (ChAT), the enzyme required for acetylcholine biosynthesis, in the peripheral and central cholinergic nervous systems. A human VAChT cDNA was used to localize the VAChT gene to chromosome 10q11.2, which is also the location of the ChAT gene. The entire sequence of the human VAChT cDNA is contained uninterrupted within the first intron of the ChAT gene locus. Transcription of VAChT and ChAT mRNA from the same or contiguous promoters within a single regulatory locus provides a previously undescribed genetic mechanism for coordinate regulation of two proteins whose expression is required to establish a mammalian neuronal phenotype.
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Citations
Cited by
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Alzheimer's disease: Targeting the Cholinergic System
H. Ferreira-Vieira, T., M. Guimaraes, I., R. Silva, F., & M. Ribeiro, F. (2016) · Current Neuropharmacology · doi:10.2174/1570159x13666150716165726 · Cited by 1,551
Arvidsson, U., Riedl, M., Elde, R., & Meister, B. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970224)378:4<454::aid-cne2>3.0.co;2-1 · Cited by 435
Kuhl, D. E., Minoshima, S., Fessler, J. A., Ficaro, E. P., Wieland, D. M., Koeppe, R. A., Frey, K. A., & Foster, N. L. (1996) · Annals of Neurology · doi:10.1002/ana.410400309 · Cited by 426
Extraneuronal cholinergic system in lymphocytes
Kawashima, K. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00071-6 · Cited by 384
Metadata
- Authors
- Erickson, J. D., Varoqui, H., Schäfer, M. K., Modi, W., Diebler, M. F., Weihe, E., Rand, J., Eiden, L. E., Bonner, T. I., & Usdin, T. B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1994-09
- Volume
- 269
- Issue
- 35
- Pages
- 21929-21932
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1935132610
- Cited by
- 385
- References
- 0
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Erickson, J. D., Varoqui, H., Schäfer, M. K., Modi, W., Diebler, M. F., Weihe, E., Rand, J., Eiden, L. E., Bonner, T. I., & Usdin, T. B. (1994). Functional identification of a vesicular acetylcholine transporter and its expression from a “cholinergic” gene locus. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)31734-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
