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Isolation and characterization of a high molecular weight glycoprotein from human blood platelets.
Open accessAbstract
A high molecular weight glycoprotein consisting of three disulfide-linked 142,000 molecular weight chains has been isolated from human blood platelets. The glycoprotein, designated thrombospondin, is released by platelets in response to thrombin treatment and is proteolyzed when left in the presence of platelets after liberation. It is relatively insensitive to degradation by thrombin. Thrombospondin is a filamentous protein of dimensions approximately 7 X 70 nm and contains 1.9% neutral sugars, 1.4% amino sugars, 0.7% sialic acid, and no hexuronic acid. Amino acid analysis reveals that the level of cysteine is approximately 260 residues per molecule. Thrombospondin binds to immobilized heparin but is released by 0.45 M sodium chloride. A single band is obtained by isoelectric focusing, indicating a pI of 4.7 as well as a relatively high degree of purity. Degradation of the intact molecule with trypsin yields a stable core particle of molecular weight 210,000 comprised of three 70,000 chains.
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Cited by
Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., et al. (2007) · Glycobiology · doi:10.1093/glycob/cwm014 · Cited by 1,026
Lillis, A. P., Van Duyn, L. B., Murphy-Ullrich, J. E., & Strickland, D. K. (2008) · Physiological Reviews · doi:10.1152/physrev.00033.2007 · Cited by 669
Molecular Basis for the Regulation of Angiogenesis by Thrombospondin-1 and -2
Lawler, P. R., & Lawler, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006627 · Cited by 532
Self-citationIsolation of the thrombospondin membrane receptor.
Asch, A. S., Barnwell, J., Silverstein, R. L., & Nachman, R. L. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112918 · Cited by 508
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393
Metadata
- Authors
- Lawler, J. W., Slayter, H. S., & Coligan, J. E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1978-12
- Volume
- 253
- Issue
- 23
- Pages
- 8609-8616
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1505957065
- Cited by
- 433
- References
- 0
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lawler, J. W., Slayter, H. S., & Coligan, J. E. (1978). Isolation and characterization of a high molecular weight glycoprotein from human blood platelets. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)34336-3
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