A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
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The anti-inflammatory, antiangiogenic, anticoagulant, and antiadhesive properties of fucoidans obtained from nine species of brown algae were studied in order to examine the influence of fucoidan origin and composition on their biological activities. All fucoidans inhibited leucocyte recruitment in an inflammation model in rats, and neither the content of fucose and sulfate nor other structural features of their polysaccharide backbones significantly affected the efficacy of fucoidans in this model. In vitro evaluation of P-selectin-mediated neutrophil adhesion to platelets under flow conditions revealed that only polysaccharides from Laminaria saccharina, L. digitata, Fucus evanescens, F. serratus, F. distichus, F. spiralis, and Ascophyllum nodosum could serve as P-selectin inhibitors. All fucoidans, except that from Cladosiphon okamuranus carrying substantial levels of 2-O-alpha-D-glucuronopyranosyl branches in the linear (1-->3)-linked poly-alpha-fucopyranoside chain, exhibited anticoagulant activity as measured by activated partial thromboplastin time whereas only fucoidans from L. saccharina, L. digitata, F. serratus, F. distichus, and F. evanescens displayed strong antithrombin activity in a platelet aggregation test. The last fucoidans potently inhibited human umbilical vein endothelial cell (HUVEC) tubulogenesis in vitro and this property correlated with decreased levels of plasminogen-activator inhibitor-1 in HUVEC supernatants, suggesting a possible mechanism of fucoidan-induced inhibition of tubulogenesis. Finally, fucoidans from L. saccharina, L. digitata, F. serratus, F. distichus, and F. vesiculosus strongly blocked MDA-MB-231 breast carcinoma cell adhesion to platelets, an effect which might have critical implications in tumor metastasis. The data presented herein provide a new rationale for the development of potential drugs for thrombosis, inflammation, and tumor progression.
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Fucoidan from brown seaweed in the order of Fucales such as F. evanescens and F. serratus contain large proportions of both α(1→3) and α(1→4) glycosidic bonds.
“several studies—using highly advanced analytical methods—have documented that fucoidan from brown seaweed in the order of Fucales such as F. evanescens and F. serratus do indeed contain large proportions of both α(1→3) and α(1→4) glycosidic bonds [20–22]”
FCSPs from C. okamuranus exert virtually no anticoagulant effect, possibly due to low sulfate in the polymer backbone and/or presence of vicinal branching points formed by 2-O-α-d-glucuronyl substituents.
“FCSPs from C. okamuranus (Chordariales) have been reported to exert virtually no anticoagulant effect, and this could be due to the low amount of sulfate in its polymer backbone and/or the presence of vicinal branching points formed by 2-O-α-d-glucuronyl substituents (Figure 4) [21,14].”
Cancer preventive action of fucoidans includes anti-inflammatory, anti-adhesive, antioxidant, and antiviral effects as well as capability to bind heavy metals.
“The cancer preventive action of fucoidans includes such useful properties as anti-inflammatory, anti-adhesive [72], antioxidant and antiviral effects [73,74,75,76] as well as their capability to bind heavy metals.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [72]
Fucoidans in the order Fucales, e.g. Fucus evanescens and Fucus serratus, possess a large proportion of both α(1→3)- and α(1→4)-linked L-fucopyranose residues, which may be substituted with sulfate on C-2 and C-4.
“The fucoidans in brown seaweeds in the order of Fucales, e.g.Fucus evanescens and Fucus serratus, represent the typical structures: They possess a large proportion of both a(1A3)and a(1A4)-linked L-fucopyranose residues, which may be substituted with sulfate (SO 3 2 ) on C-2 and C-4 (Table 1).6,7,10”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [6]
Algal fucoidans have diverse biological functions and possible therapeutic properties including antitumor, immunomodulatory, anti-inflammatory, antithrombotic, and anticoagulant effects.
“Algal fucoidans have been the subject of numerous scientific studies due to their diverse biological functions and possible therapeutic properties including antitumor, immunomodulatory, 45 anti-inflammatory, 6 antithrombotic, and anticoagulant effects.46”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [6]
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- Authors
- Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., Usov, A. I., Ustyuzhanina, N. E., Grachev, A. A., Sanderson, C. J., Kelly, M., Rabinovich, G. A., Iacobelli, S., & Nifantiev, N. E.
- Affiliations
- University of Chieti-Pescara (IT)
- Institute of Biomedical Chemistry (RU)
- Mario Negri Sud Foundation (IT)
- Russian Academy of Sciences (RU)
- Scottish Association For Marine Science (GB)
- Universidad de Buenos Aires (AR)
- Venue
- Glycobiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-02-12
- Volume
- 17
- Issue
- 5
- Pages
- 541-552
- ISSN
- 0959-6658 (ISSN-L)
- 1460-2423
- OpenAlex
- W2007020765
- Cited by
- 1,026
- References
- 57
- Citations by year
- 2026: 38 · 2025: 41 · 2024: 64 · 2023: 51 · 2022: 67 · 2021: 57 · 2020: 79 · 2019: 67 · 2018: 66 · 2017: 54 · 2016: 84 · 2015: 55 · 2014: 63 · 2013: 61 · 2012: 52
- FWCI
- 31.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Glycobiology (publishedVersion)
- PubMed (publishedVersion)
- Conicet (submittedVersion, cc-by-nc-sa)
- Funders
- Russian Foundation for Basic Research
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- fucoidan, brown algae, anti-inflammatory activity, anticoagulant activity, antiangiogenic activity, anti-adhesion activity, neutrophil adhesion, Laminaria, Fucus, Ascophyllum nodosum, Cladosiphon okamuranus, plasminogen activator inhibitor-1, tubulogenesis, metastasis, thrombosis, inflammation, sulfated polysaccharides
- MeSH terms
- Phaeophyceae, Anti-Inflammatory Agents, Non-Steroidal, Blood Platelets, Cell Adhesion, Humans, Inflammation, Neoplasms, Polysaccharides, Seaweed, Thrombosis, Umbilical Veins, Plasminogen Activator Inhibitor 1, Angiogenesis Inhibitors, Endothelial Cells, Cell Line, Tumor
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