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Muscarinic cholinergic receptor modulation of beta-adrenergic receptor affinity for catecholamines.
Open accessAbstract
The effects of the muscarinic cholinergic agonist methacholine on affinity of beta-adrenergic receptors for isoproterenol and on isoproterenol-induced stimulation of adenylate cyclase activity were assessed in canine myocardium. GTP and guanyl-5'-yl imidoiphosphate both decreased the affinity of beta-adrenergic receptors for isoproterenol without altering the affinity of these receptors for propranolol. Methacholine (10 nM to 10 micronM) antagonized the guanine nucleotide-induced reduction in beta-adrenergic receptor affinity for isoproterenol. This effect of methacholine was reversed by atropine. The choline ester had no effect on the affinity of beta-adrenergic receptors for isoproterenol in the absence of guanine nucleotides. Likewise, methacholine had no effect on the affinity of beta-adrenergic receptors for propranolol, either in the presence or absence of guanine nucleotides. Methacholine also attenuated GTP-induced activation of adenylate cyclase or isoproterenol-induced activation of the enzyme in the presence of GTP. The effects of methacholine on myocardial adenylate cyclase activity were apparent only in the presence of GTP. These effects were also reversed by atropine. The choline ester had no effect on adenylate cyclase activity in the presence of guanyl-5'-yl imidodiphosphate or NaF. The results of the present study suggest that muscarinic cholinergic agonists can regulate both beta-adrenergic receptors and adenylate cyclase by modulating the effects of GTP.
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Citations
Cites
Yung-Chi, C., & Prusoff, W. H. (1973) · Biochemical Pharmacology · doi:10.1016/0006-2952(73)90196-2 · Cited by 12,922
Cited by
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Rodbell, M. (1980) · Nature · doi:10.1038/284017a0 · Cited by 1,749
Hormonal regulation of peptide receptors and target cell responses
Catt, K. J., Harwood, J. P., Aguilera, G., & Dufau, M. L. (1979) · Nature · doi:10.1038/280109a0 · Cited by 532
Lerman, B. B., Belardinelli, L., West, G. A., Berne, R. M., & DiMarco, J. P. (1986) · Circulation · doi:10.1161/01.cir.74.2.270 · Cited by 473
Xhyheri, B., Manfrini, O., Mazzolini, M., Pizzi, C., & Bugiardini, R. (2012) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2012.09.001 · Cited by 447
Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems
Hartzell, H. C. (1988) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(88)90014-4 · Cited by 398
Metadata
- Authors
- Watanabe, A. M., McConnaughey, M. M., Strawbridge, R. A., Fleming, J. W., Jones, L. R., & Besch, H. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1978-07
- Volume
- 253
- Issue
- 14
- Pages
- 4833-4836
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1513161378
- Cited by
- 224
- References
- 1
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Watanabe, A. M., McConnaughey, M. M., Strawbridge, R. A., Fleming, J. W., Jones, L. R., & Besch, H. R. (1978). Muscarinic cholinergic receptor modulation of beta-adrenergic receptor affinity for catecholamines. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)34620-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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