Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
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The inhibition constant (Ki) value for the reversal of DHT action by hydroxyflutamide was estimated at 39 nM, in agreement with the affinity of the antagonist for the AR.
“The inhibition constant (K i ) value for the reversal of DHT action by hydroxyflutamide was estimated at 39 nm (233), in agreement with the affinity of the antagonist for the AR (227).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [233]
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- Authors
- Yung-Chi, C., & Prusoff, W. H.
- Affiliations
- Yale University (US)
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 1973-12
- Volume
- 22
- Issue
- 23
- Pages
- 3099-3108
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W2074631079
- Cited by
- 12,922
- References
- 13
- Citations by year
- 2026: 202 · 2025: 242 · 2024: 247 · 2023: 218 · 2022: 258 · 2021: 298 · 2020: 274 · 2019: 279 · 2018: 295 · 2017: 326 · 2016: 328 · 2015: 357 · 2014: 347 · 2013: 359 · 2012: 371
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme function and inhibition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › thermodynamics and calorimetric analyses
- Keywords
- enzyme inhibition, inhibition constant, competitive inhibition, non-competitive inhibition, uncompetitive inhibition, inhibition kinetics, substrate concentration dependence
- MeSH terms
- Binding, Competitive, Enzyme Inhibitors, Kinetics, Mathematics
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