Cited by 12,922Enzyme function and inhibitionBiochemical and Molecular Researchthermodynamics and calorimetric analyses

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi, Cheng, Prusoff, William H.·1973·Biochemical Pharmacology

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Crossref · 10.1016/0006-2952(73)90196-2

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13 of 13 references verified0 citation errors · 0 not checkable

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Authors
Yung-Chi, C., & Prusoff, W. H.
Affiliations
Yale University (US)
Venue
Biochemical Pharmacology
Publisher
Elsevier BV
Published
1973-12
Volume
22
Issue
23
Pages
3099-3108
ISSN
0006-2952 (ISSN-L)
OpenAlex
W2074631079
Cited by
12,922
References
13
Citations by year
2026: 202 · 2025: 242 · 2024: 247 · 2023: 218 · 2022: 258 · 2021: 298 · 2020: 274 · 2019: 279 · 2018: 295 · 2017: 326 · 2016: 328 · 2015: 357 · 2014: 347 · 2013: 359 · 2012: 371
FWCI
4.87
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme function and inhibition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › thermodynamics and calorimetric analyses
Keywords
enzyme inhibition, inhibition constant, competitive inhibition, non-competitive inhibition, uncompetitive inhibition, inhibition kinetics, substrate concentration dependence
MeSH terms
Binding, Competitive, Enzyme Inhibitors, Kinetics, Mathematics

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