The DOI matches its Crossref record.
Purification of the fibroblast growth factor activity from bovine brain.
Open accessAbstract
The purification of the fibroblast growth factor (FGF) from bovine brain has led to the isolation of two peptides. FGF-1 with 128 amino acids and FGF-2 with 107 amino acids. The biological activity of these two peptides is acid- and heat-labile. As indicated by the amino acid composition of FGF-1 and -2, these two peptides are derived from a common precursor and bear no resemblance to pituitary FGF. The brain FGF peptides, like pituitary FGF, are mitogenic in vitro for the same wide variety of mesoderm-derived cells. Since their mitogenic activity is acid- and heat-labile, they are thereby distinguished from the platelet factor isolated from platelets and from the cationic peptide isolated from serum which has been shown to have the same molecular weight and isoelectric point as brain and pituitary FGF.
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Citations
Cited by
Folkman, J., & Klagsbrun, M. (1987) · Science · doi:10.1126/science.2432664 · Cited by 3,491
Structural and Functional Diversity in the FGf Receptor Multigene Family
(1992) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60821-0 · Cited by 1,250
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein
Kruijer, W., Cooper, J. A., Hunter, T., & Verma, I. M. (1984) · Nature · doi:10.1038/312711a0 · Cited by 916
Heparin protects basic and acidic FGF from inactivation
Gospodarowicz, D., & Cheng, J. (1986) · Journal of Cellular Physiology · doi:10.1002/jcp.1041280317 · Cited by 853
Self-citationKnusel, B., Michel, P., Schwaber, J., & Hefti, F. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-02-00558.1990 · Cited by 521
Metadata
- Authors
- Gospodarowicz, D., Bialecki, H., & Greenburg, G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1978-05
- Volume
- 253
- Issue
- 10
- Pages
- 3736-3743
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1502488284
- Cited by
- 492
- References
- 0
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gospodarowicz, D., Bialecki, H., & Greenburg, G. (1978). Purification of the fibroblast growth factor activity from bovine brain. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)34863-9
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